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UniProtKB - Q3U574 (Q3U574_MOUSE)

Entry version 118 (19 Jan 2022)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Uncharacterized protein

Gene

Timeless

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythmsARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TimelessImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1321393, Timeless

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000039994

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3U574

PeptideAtlas

More...PeptideAtlasi		Q3U574

PRoteomics IDEntifications database

More...PRIDEi		Q3U574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039994, Expressed in primary oocyte and 249 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3U574, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3U574

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 283TIMELESSInterPro annotationAdd BLAST260
Domaini1003 – 1089TIMELESS_CInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni647 – 674DisorderedSequence analysisAdd BLAST28
Regioni943 – 1002DisorderedSequence analysisAdd BLAST60
Regioni1088 – 1196DisorderedSequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi657 – 674Acidic residuesSequence analysisAdd BLAST18
Compositional biasi964 – 986Acidic residuesSequence analysisAdd BLAST23
Compositional biasi988 – 1002Polar residuesSequence analysisAdd BLAST15
Compositional biasi1116 – 1144Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi1151 – 1165Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1172 – 1196Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the timeless family.ARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		839367at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044998, Timeless
IPR007725, TIMELESS_C
IPR006906, Timeless_N

The PANTHER Classification System

More...PANTHERi		PTHR22940, PTHR22940, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04821, TIMELESS, 1 hit
PF05029, TIMELESS_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3U574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLYMMNCEL LATCSALGYL EGGTYHKEPD CLESVKDLIR YLRHEDETRD 
        60         70         80         90        100
VRQQLGAAQI LQSDLLPILT QHRQDKPLFD AVIRLMVNLT QPALLCFGSV 
       110        120        130        140        150
PKDSSVRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEDRQE 
       160        170        180        190        200
EDNLLIERIL LLVRNILHVP ANLEQEKSID DDASIHDRLL WAIHLSGMDD 
       210        220        230        240        250
LLLFLSSSSA EQQWSLHVLE IISLMFRDQT PEQLAGVGQG RLAQERSTDV 
       260        270        280        290        300
AELEVLRQRE MAEKRARALQ RGNRHSRFGG SYIVQGLKSI GEKDVVFHKG 
       310        320        330        340        350
LHNLQNYSSD LGKQPRRVPK RRQAAQELSV HRRSVLNVRL FLRDFCSEFL 
       360        370        380        390        400
ENCYNPLMGA VKDHLLRERA QQHDETYYMW AMAFFMAFNR AATFRPGLVS 
       410        420        430        440        450
ETLSIRTFHF VEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV 
       460        470        480        490        500
NEMDMCPDEA VRESSRIIKN NIFYMMEYRE LFLALFRKFD ERYHPRSFLR 
       510        520        530        540        550
DLVETTHLFL KMLERFCRSR GNLMVQNKRK KRKKKKKVQD QGVAFSQSPG 
       560        570        580        590        600
ELEAMWPALA EQLLQCAQDP ELSVDPVVPF DAASEVPVEE QRVEAMVRIQ 
       610        620        630        640        650
DCLTAGQAPQ ALALLRSARE VWPEGNAFGS PVISPGEEMQ LLKQILSTPL 
       660        670        680        690        700
PRQQEPEEGD AEEEEEEEEE EELQVVQVSE KEFNFLEYLK RFASSTIVRA 
       710        720        730        740        750
YVLLLRSYRQ NSAHTNHCIA KMLHRLAHGL GMEALLFQLS LFCLFNRLLS 
       760        770        780        790        800
DPAAAAYKEL VTFAKYIIGK FFALAAVNQK AFVELLFWKN TAVVREMTQG 
       810        820        830        840        850
YGSLDSGSSS HRAPLWSPEE EAQLQELYLA HKDVEGQDVV ETILAHLKVV 
       860        870        880        890        900
PRTRKQVIHH LVRMGLADSV KEFQKRKGTQ IVLWTEDQEL ELQRLFEEFR 
       910        920        930        940        950
DSDDVLGQIM KNITAKRSRA RVVDKLLALG LVSERRQLYK KRRKKLAPSC 
       960        970        980        990       1000
MQNGEKSPRD PWQEDPEEED EHLPEDESED EESEEGLPSG QGQGSSSLSA 
      1010       1020       1030       1040       1050
ENLGESLRQE GLSAPLLWLQ SSLIRAANDR EEDGCSQAIP LVPLTEENEE 
      1060       1070       1080       1090       1100
AMENEQFQHL LRKLGIRPPS SGQETFWRIP AKLSSTQLRR VAASLSQQEN 
      1110       1120       1130       1140       1150
EEEREEEPEP GVPGEQGPSE EHRTEALRAL LSARKRKAGL GPTEEEATGE 
      1160       1170       1180       1190 
EEWNSAPKKR QLLDSDEEED DEGRRQVSGT PRVHRKKRFQ IEDEDD
Length:1,196
Mass (Da):137,432
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED8B120D87B20E44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK153838 mRNA Translation: BAE32206.1

NCBI Reference Sequences

More...RefSeqi		NP_001157552.1, NM_001164080.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		21853

UCSC genome browser

More...UCSCi		uc007hlu.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153838 mRNA Translation: BAE32206.1
RefSeqiNP_001157552.1, NM_001164080.1

3D structure databases

SMRiQ3U574
ModBaseiSearch...

Proteomic databases

EPDiQ3U574
PeptideAtlasiQ3U574
PRIDEiQ3U574

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15850, 204 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		21853

Genome annotation databases

GeneIDi21853
UCSCiuc007hlu.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8914
MGIiMGI:1321393, Timeless
VEuPathDBiHostDB:ENSMUSG00000039994

Phylogenomic databases

OrthoDBi839367at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		21853, 24 hits in 66 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Timeless, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039994, Expressed in primary oocyte and 249 other tissues
GenevisibleiQ3U574, MM

Family and domain databases

InterProiView protein in InterPro
IPR044998, Timeless
IPR007725, TIMELESS_C
IPR006906, Timeless_N
PANTHERiPTHR22940, PTHR22940, 1 hit
PfamiView protein in Pfam
PF04821, TIMELESS, 1 hit
PF05029, TIMELESS_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3U574_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U574
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 19, 2022
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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