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Entry version 109 (26 Feb 2020)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Uncharacterized protein

Gene

Timeless

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TimelessImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1321393 Timeless

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q3U574

PeptideAtlas

More...
PeptideAtlasi
Q3U574

PRoteomics IDEntifications database

More...
PRIDEi
Q3U574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039994 Expressed in primary oocyte and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3U574 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U574 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3U574

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 283TIMELESSInterPro annotationAdd BLAST260
Domaini722 – 1179TIMELESS_CInterPro annotationAdd BLAST458

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni647 – 674DisorderedSequence analysisAdd BLAST28
Regioni943 – 1002DisorderedSequence analysisAdd BLAST60
Regioni1088 – 1196DisorderedSequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi657 – 674AcidicSequence analysisAdd BLAST18
Compositional biasi964 – 986AcidicSequence analysisAdd BLAST23
Compositional biasi988 – 1002PolarSequence analysisAdd BLAST15
Compositional biasi1116 – 1144PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1151 – 1165PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1172 – 1196PolyampholyteSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1974 Eukaryota
ENOG410XQM6 LUCA

Database of Orthologous Groups

More...
OrthoDBi
839367at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006906 Timeless
IPR007725 TIMELESS_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04821 TIMELESS, 1 hit
PF05029 TIMELESS_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3U574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLYMMNCEL LATCSALGYL EGGTYHKEPD CLESVKDLIR YLRHEDETRD
60 70 80 90 100
VRQQLGAAQI LQSDLLPILT QHRQDKPLFD AVIRLMVNLT QPALLCFGSV
110 120 130 140 150
PKDSSVRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEDRQE
160 170 180 190 200
EDNLLIERIL LLVRNILHVP ANLEQEKSID DDASIHDRLL WAIHLSGMDD
210 220 230 240 250
LLLFLSSSSA EQQWSLHVLE IISLMFRDQT PEQLAGVGQG RLAQERSTDV
260 270 280 290 300
AELEVLRQRE MAEKRARALQ RGNRHSRFGG SYIVQGLKSI GEKDVVFHKG
310 320 330 340 350
LHNLQNYSSD LGKQPRRVPK RRQAAQELSV HRRSVLNVRL FLRDFCSEFL
360 370 380 390 400
ENCYNPLMGA VKDHLLRERA QQHDETYYMW AMAFFMAFNR AATFRPGLVS
410 420 430 440 450
ETLSIRTFHF VEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV
460 470 480 490 500
NEMDMCPDEA VRESSRIIKN NIFYMMEYRE LFLALFRKFD ERYHPRSFLR
510 520 530 540 550
DLVETTHLFL KMLERFCRSR GNLMVQNKRK KRKKKKKVQD QGVAFSQSPG
560 570 580 590 600
ELEAMWPALA EQLLQCAQDP ELSVDPVVPF DAASEVPVEE QRVEAMVRIQ
610 620 630 640 650
DCLTAGQAPQ ALALLRSARE VWPEGNAFGS PVISPGEEMQ LLKQILSTPL
660 670 680 690 700
PRQQEPEEGD AEEEEEEEEE EELQVVQVSE KEFNFLEYLK RFASSTIVRA
710 720 730 740 750
YVLLLRSYRQ NSAHTNHCIA KMLHRLAHGL GMEALLFQLS LFCLFNRLLS
760 770 780 790 800
DPAAAAYKEL VTFAKYIIGK FFALAAVNQK AFVELLFWKN TAVVREMTQG
810 820 830 840 850
YGSLDSGSSS HRAPLWSPEE EAQLQELYLA HKDVEGQDVV ETILAHLKVV
860 870 880 890 900
PRTRKQVIHH LVRMGLADSV KEFQKRKGTQ IVLWTEDQEL ELQRLFEEFR
910 920 930 940 950
DSDDVLGQIM KNITAKRSRA RVVDKLLALG LVSERRQLYK KRRKKLAPSC
960 970 980 990 1000
MQNGEKSPRD PWQEDPEEED EHLPEDESED EESEEGLPSG QGQGSSSLSA
1010 1020 1030 1040 1050
ENLGESLRQE GLSAPLLWLQ SSLIRAANDR EEDGCSQAIP LVPLTEENEE
1060 1070 1080 1090 1100
AMENEQFQHL LRKLGIRPPS SGQETFWRIP AKLSSTQLRR VAASLSQQEN
1110 1120 1130 1140 1150
EEEREEEPEP GVPGEQGPSE EHRTEALRAL LSARKRKAGL GPTEEEATGE
1160 1170 1180 1190
EEWNSAPKKR QLLDSDEEED DEGRRQVSGT PRVHRKKRFQ IEDEDD
Length:1,196
Mass (Da):137,432
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED8B120D87B20E44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK153838 mRNA Translation: BAE32206.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157552.1, NM_001164080.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
21853

UCSC genome browser

More...
UCSCi
uc007hlu.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153838 mRNA Translation: BAE32206.1
RefSeqiNP_001157552.1, NM_001164080.1

3D structure databases

SMRiQ3U574
ModBaseiSearch...

Proteomic databases

EPDiQ3U574
PeptideAtlasiQ3U574
PRIDEiQ3U574

Genome annotation databases

GeneIDi21853
UCSCiuc007hlu.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8914
MGIiMGI:1321393 Timeless

Phylogenomic databases

eggNOGiKOG1974 Eukaryota
ENOG410XQM6 LUCA
OrthoDBi839367at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Timeless mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039994 Expressed in primary oocyte and 221 other tissues
ExpressionAtlasiQ3U574 baseline and differential
GenevisibleiQ3U574 MM

Family and domain databases

InterProiView protein in InterPro
IPR006906 Timeless
IPR007725 TIMELESS_C
PfamiView protein in Pfam
PF04821 TIMELESS, 1 hit
PF05029 TIMELESS_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3U574_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U574
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 26, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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