UniProtKB - Q3U564 (DCP1B_MOUSE)

BLAST

>sp|Q3U564|DCP1B_MOUSE mRNA-decapping enzyme 1B OS=Mus musculus OX=10090 GN=Dcp1b PE=1 SV=1
MAAAAAGGLPGKGHDISLAALRRHDPYISRIVDVASQVALYTFGHRANEWEKTGVEGTLF
VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQNPFLLYRNGTLSIYGIWFYDKEEC
QRIAKLMKNLTQSEQLKACHGAGSSPVTLSSGEGQEVDILQMLTKAKDEYTKCKTCSEPK
QMTNSSAICDNPKLIKPVPVRPSSSQRLQGPAPSKTSDPEPQHLSLTALFGKQDKAPCQE
TVKPSRTFAHHHHHHHQQQQETRPVHHGVACSLSCEEPRKLSLPVEKQLCPAIQKLMLGS
PGLHPLPQHPEQWSCKSGSPSPAGGILPGPVQLGSPWNGRVAHCTQSTCRGHKLLEQLQG
APGAVHKYNPCAPTGPAVATQVAPGQSVAQSQLVYFSGPLQPPAPGHQALRKEQGALPAQ
AVSLSGSQESSPTVLPTQELLRKLQVVHQEQQAAPRPALAARFPVSAQGSGTEKPLEAWV
SKTASMEKQAPLLQSTCAPLRETDNGLMALGGQELPAASSNLLLPLQNWESSTVASRPLT
RLQLQEALLNLIQNDDNFLSIIYEAYLFSVTQAAMRTT

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History
Entry version 91 (07 Nov 2018)
Sequence version 1 (11 Oct 2005)
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Protein

mRNA-decapping enzyme 1B

Gene

Dcp1b

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).By similarity

GO - Molecular functionⁱ

enzyme activator activity Source: InterPro
hydrolase activity Source: UniProtKB-KW
mRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

deadenylation-dependent decapping of nuclear-transcribed mRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
deadenylation-independent decapping of nuclear-transcribed mRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Nonsense-mediated mRNA decay

Enzyme and pathway databases

Reactomeⁱ	R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Reactomeⁱ

R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: mRNA-decapping enzyme 1B (EC:3.-.-.-)
Gene namesⁱ	Name:Dcp1b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:2442404 Dcp1b

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000287718	2 – 578	mRNA-decapping enzyme 1BAdd BLAST		577

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	144	PhosphoserineCombined sources	1
Modified residueⁱ	145	PhosphoserineBy similarity	1
Modified residueⁱ	274	PhosphoserineBy similarity	1
Modified residueⁱ	335	PhosphoserineBy similarity	1
Modified residueⁱ	380	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3U564
PaxDbⁱ	Q3U564
PRIDEⁱ	Q3U564

PTM databases

iPTMnetⁱ	Q3U564
PhosphoSitePlusⁱ	Q3U564

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000041477 Expressed in 204 organ(s), highest expression level in testis
CleanExⁱ	MM_DCP1B
ExpressionAtlasⁱ	Q3U564 baseline and differential
Genevisibleⁱ	Q3U564 MM

Interactionⁱ

Subunit structureⁱ

Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6 (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000108397

STRINGⁱ

10090.ENSMUSP00000108397

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3U564
SMRⁱ	Q3U564
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DCP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2868 Eukaryota ENOG410XRY6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014855
HOGENOMⁱ	HOG000090228
HOVERGENⁱ	HBG103159
InParanoidⁱ	Q3U564
PhylomeDBⁱ	Q3U564

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR010334 Dcp1 IPR031953 mRNA_decap_C IPR011993 PH-like_dom_sf
PANTHERⁱ	PTHR16290 PTHR16290, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06058 DCP1, 1 hit PF16741 mRNA_decap_C, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q3U564-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAGGLP GKGHDISLAA LRRHDPYISR IVDVASQVAL YTFGHRANEW 
        60         70         80         90        100
EKTGVEGTLF VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQNPFL 
       110        120        130        140        150
LYRNGTLSIY GIWFYDKEEC QRIAKLMKNL TQSEQLKACH GAGSSPVTLS 
       160        170        180        190        200
SGEGQEVDIL QMLTKAKDEY TKCKTCSEPK QMTNSSAICD NPKLIKPVPV 
       210        220        230        240        250
RPSSSQRLQG PAPSKTSDPE PQHLSLTALF GKQDKAPCQE TVKPSRTFAH 
       260        270        280        290        300
HHHHHHQQQQ ETRPVHHGVA CSLSCEEPRK LSLPVEKQLC PAIQKLMLGS 
       310        320        330        340        350
PGLHPLPQHP EQWSCKSGSP SPAGGILPGP VQLGSPWNGR VAHCTQSTCR 
       360        370        380        390        400
GHKLLEQLQG APGAVHKYNP CAPTGPAVAT QVAPGQSVAQ SQLVYFSGPL 
       410        420        430        440        450
QPPAPGHQAL RKEQGALPAQ AVSLSGSQES SPTVLPTQEL LRKLQVVHQE 
       460        470        480        490        500
QQAAPRPALA ARFPVSAQGS GTEKPLEAWV SKTASMEKQA PLLQSTCAPL 
       510        520        530        540        550
RETDNGLMAL GGQELPAASS NLLLPLQNWE SSTVASRPLT RLQLQEALLN 
       560        570 
LIQNDDNFLS IIYEAYLFSV TQAAMRTT

Length:578

Mass (Da):62,720

Last modified:October 11, 2005 - v1

Checksum:ⁱ14194466EDA5B1CD

Isoform 2 (identifier: Q3U564-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
495-527: Missing.

« Hide

        10         20         30         40         50
MAAAAAGGLP GKGHDISLAA LRRHDPYISR IVDVASQVAL YTFGHRANEW 
        60         70         80         90        100
EKTGVEGTLF VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQNPFL 
       110        120        130        140        150
LYRNGTLSIY GIWFYDKEEC QRIAKLMKNL TQSEQLKACH GAGSSPVTLS 
       160        170        180        190        200
SGEGQEVDIL QMLTKAKDEY TKCKTCSEPK QMTNSSAICD NPKLIKPVPV 
       210        220        230        240        250
RPSSSQRLQG PAPSKTSDPE PQHLSLTALF GKQDKAPCQE TVKPSRTFAH 
       260        270        280        290        300
HHHHHHQQQQ ETRPVHHGVA CSLSCEEPRK LSLPVEKQLC PAIQKLMLGS 
       310        320        330        340        350
PGLHPLPQHP EQWSCKSGSP SPAGGILPGP VQLGSPWNGR VAHCTQSTCR 
       360        370        380        390        400
GHKLLEQLQG APGAVHKYNP CAPTGPAVAT QVAPGQSVAQ SQLVYFSGPL 
       410        420        430        440        450
QPPAPGHQAL RKEQGALPAQ AVSLSGSQES SPTVLPTQEL LRKLQVVHQE 
       460        470        480        490        500
QQAAPRPALA ARFPVSAQGS GTEKPLEAWV SKTASMEKQA PLLQNWESST 
       510        520        530        540 
VASRPLTRLQ LQEALLNLIQ NDDNFLSIIY EAYLFSVTQA AMRTT

Note: No experimental confirmation available.

Show »

Length:545

Mass (Da):59,357

Checksum:ⁱCC9D1FE5A1C4AED6

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B9EIX0	B9EIX0_MOUSE		DCP1 decapping enzyme homolog b (S.... DCP1 decapping enzyme homolog b (S. cerevisiae) (MCG131714) (mRNA-decapping enzyme 1B)	Dcp1b mCG_131714	578	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_025609	495 – 527	Missing in isoform 2. 1 PublicationAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK050548 mRNA Translation: BAE20676.1 AK153860 mRNA Translation: BAE32216.1 BC141163 mRNA Translation: AAI41164.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39610.1 [Q3U564-1]
UniGeneⁱ	Mm.250197

Genome annotation databases

Ensemblⁱ	ENSMUST00000073909; ENSMUSP00000073568; ENSMUSG00000041477 [Q3U564-2]
UCSC genome browser More...UCSCⁱ	uc009dly.2 mouse [Q3U564-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3U564	Decapping mRNA 1B		RAT		582	UniRef90_Q3U564
DCP1 decapping enzyme homolog b (S. cerevisiae)		MOUSE		578
UPI000A3101FA		MUSPA		586
UPI000A31AD43		MUSCR		476
UPI0007ED1DCD		MOUSE		417
+1

Protein	Similar proteins		Species	Score	Length	Source
Q3U564	mRNA-decapping enzyme 1B		HUMAN		617	UniRef50_Q8IZD4
mRNA-decapping enzyme 1B		PONAB		609
Uncharacterized protein		MACMU		722
DCP1-decapping enzyme homolog B (S. cerevisiae) (Fragment)		NEOVI		94
Uncharacterized protein (Fragment)		MACFA		668
+287

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK050548 mRNA Translation: BAE20676.1 AK153860 mRNA Translation: BAE32216.1 BC141163 mRNA Translation: AAI41164.1
CCDSⁱ	CCDS39610.1 [Q3U564-1]
UniGeneⁱ	Mm.250197

3D structure databases

ProteinModelPortalⁱ	Q3U564
SMRⁱ	Q3U564
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000108397

STRINGⁱ

10090.ENSMUSP00000108397

PTM databases

iPTMnetⁱ	Q3U564
PhosphoSitePlusⁱ	Q3U564

Proteomic databases

MaxQBⁱ	Q3U564
PaxDbⁱ	Q3U564
PRIDEⁱ	Q3U564

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000073909; ENSMUSP00000073568; ENSMUSG00000041477 [Q3U564-2]
UCSCⁱ	uc009dly.2 mouse [Q3U564-2]

Organism-specific databases

MGIⁱ	MGI:2442404 Dcp1b

Phylogenomic databases

eggNOGⁱ	KOG2868 Eukaryota ENOG410XRY6 LUCA
GeneTreeⁱ	ENSGT00390000014855
HOGENOMⁱ	HOG000090228
HOVERGENⁱ	HBG103159
InParanoidⁱ	Q3U564
PhylomeDBⁱ	Q3U564

Enzyme and pathway databases

Reactomeⁱ	R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Reactomeⁱ

R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3U564
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000041477 Expressed in 204 organ(s), highest expression level in testis
CleanExⁱ	MM_DCP1B
ExpressionAtlasⁱ	Q3U564 baseline and differential
Genevisibleⁱ	Q3U564 MM

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR010334 Dcp1 IPR031953 mRNA_decap_C IPR011993 PH-like_dom_sf
PANTHERⁱ	PTHR16290 PTHR16290, 2 hits
Pfamⁱ	View protein in Pfam PF06058 DCP1, 1 hit PF16741 mRNA_decap_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCP1B_MOUSE
Accessionⁱ	Q3U564Primary (citable) accession number: Q3U564 Secondary accession number(s): B2RUI2, Q3V333
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3U564 (DCP1B_MOUSE)

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mRNA-decapping enzyme 1B

Dcp1b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ