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Protein

mRNA-decapping enzyme 1B

Gene

Dcp1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).By similarity

GO - Molecular functioni

  • enzyme activator activity Source: InterPro
  • hydrolase activity Source: UniProtKB-KW
  • mRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1B (EC:3.-.-.-)
Gene namesi
Name:Dcp1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2442404 Dcp1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002877182 – 578mRNA-decapping enzyme 1BAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1
Modified residuei274PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei380PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3U564
PaxDbiQ3U564
PRIDEiQ3U564

PTM databases

iPTMnetiQ3U564
PhosphoSitePlusiQ3U564

Expressioni

Gene expression databases

BgeeiENSMUSG00000041477 Expressed in 204 organ(s), highest expression level in testis
CleanExiMM_DCP1B
ExpressionAtlasiQ3U564 baseline and differential
GenevisibleiQ3U564 MM

Interactioni

Subunit structurei

Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108397

Structurei

3D structure databases

ProteinModelPortaliQ3U564
SMRiQ3U564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

eggNOGiKOG2868 Eukaryota
ENOG410XRY6 LUCA
GeneTreeiENSGT00390000014855
HOGENOMiHOG000090228
HOVERGENiHBG103159
InParanoidiQ3U564
PhylomeDBiQ3U564

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010334 Dcp1
IPR031953 mRNA_decap_C
IPR011993 PH-like_dom_sf
PANTHERiPTHR16290 PTHR16290, 2 hits
PfamiView protein in Pfam
PF06058 DCP1, 1 hit
PF16741 mRNA_decap_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U564-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAGGLP GKGHDISLAA LRRHDPYISR IVDVASQVAL YTFGHRANEW
60 70 80 90 100
EKTGVEGTLF VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQNPFL
110 120 130 140 150
LYRNGTLSIY GIWFYDKEEC QRIAKLMKNL TQSEQLKACH GAGSSPVTLS
160 170 180 190 200
SGEGQEVDIL QMLTKAKDEY TKCKTCSEPK QMTNSSAICD NPKLIKPVPV
210 220 230 240 250
RPSSSQRLQG PAPSKTSDPE PQHLSLTALF GKQDKAPCQE TVKPSRTFAH
260 270 280 290 300
HHHHHHQQQQ ETRPVHHGVA CSLSCEEPRK LSLPVEKQLC PAIQKLMLGS
310 320 330 340 350
PGLHPLPQHP EQWSCKSGSP SPAGGILPGP VQLGSPWNGR VAHCTQSTCR
360 370 380 390 400
GHKLLEQLQG APGAVHKYNP CAPTGPAVAT QVAPGQSVAQ SQLVYFSGPL
410 420 430 440 450
QPPAPGHQAL RKEQGALPAQ AVSLSGSQES SPTVLPTQEL LRKLQVVHQE
460 470 480 490 500
QQAAPRPALA ARFPVSAQGS GTEKPLEAWV SKTASMEKQA PLLQSTCAPL
510 520 530 540 550
RETDNGLMAL GGQELPAASS NLLLPLQNWE SSTVASRPLT RLQLQEALLN
560 570
LIQNDDNFLS IIYEAYLFSV TQAAMRTT
Length:578
Mass (Da):62,720
Last modified:October 11, 2005 - v1
Checksum:i14194466EDA5B1CD
GO
Isoform 2 (identifier: Q3U564-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-527: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):59,357
Checksum:iCC9D1FE5A1C4AED6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9EIX0B9EIX0_MOUSE
DCP1 decapping enzyme homolog b (S....
Dcp1b mCG_131714
578Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025609495 – 527Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050548 mRNA Translation: BAE20676.1
AK153860 mRNA Translation: BAE32216.1
BC141163 mRNA Translation: AAI41164.1
CCDSiCCDS39610.1 [Q3U564-1]
UniGeneiMm.250197

Genome annotation databases

EnsembliENSMUST00000073909; ENSMUSP00000073568; ENSMUSG00000041477 [Q3U564-2]
UCSCiuc009dly.2 mouse [Q3U564-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050548 mRNA Translation: BAE20676.1
AK153860 mRNA Translation: BAE32216.1
BC141163 mRNA Translation: AAI41164.1
CCDSiCCDS39610.1 [Q3U564-1]
UniGeneiMm.250197

3D structure databases

ProteinModelPortaliQ3U564
SMRiQ3U564
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108397

PTM databases

iPTMnetiQ3U564
PhosphoSitePlusiQ3U564

Proteomic databases

MaxQBiQ3U564
PaxDbiQ3U564
PRIDEiQ3U564

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073909; ENSMUSP00000073568; ENSMUSG00000041477 [Q3U564-2]
UCSCiuc009dly.2 mouse [Q3U564-2]

Organism-specific databases

MGIiMGI:2442404 Dcp1b

Phylogenomic databases

eggNOGiKOG2868 Eukaryota
ENOG410XRY6 LUCA
GeneTreeiENSGT00390000014855
HOGENOMiHOG000090228
HOVERGENiHBG103159
InParanoidiQ3U564
PhylomeDBiQ3U564

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

PROiPR:Q3U564
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041477 Expressed in 204 organ(s), highest expression level in testis
CleanExiMM_DCP1B
ExpressionAtlasiQ3U564 baseline and differential
GenevisibleiQ3U564 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010334 Dcp1
IPR031953 mRNA_decap_C
IPR011993 PH-like_dom_sf
PANTHERiPTHR16290 PTHR16290, 2 hits
PfamiView protein in Pfam
PF06058 DCP1, 1 hit
PF16741 mRNA_decap_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCP1B_MOUSE
AccessioniPrimary (citable) accession number: Q3U564
Secondary accession number(s): B2RUI2, Q3V333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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