UniProtKB - Q3U564 (DCP1B_MOUSE)
mRNA-decapping enzyme 1B
Dcp1b
Functioni
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).
By similarityCatalytic activityi
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GDPBy similarityEC:3.6.1.62By similarityThis reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- enzyme activator activity Source: InterPro
- hydrolase activity Source: UniProtKB-KW
- mRNA binding Source: GO_Central
GO - Biological processi
- cellular response to interleukin-17 Source: MGI
- deadenylation-dependent decapping of nuclear-transcribed mRNA Source: GO_Central
- deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
- positive regulation of catalytic activity Source: InterPro
- protein localization to nucleus Source: MGI
- protein localization to P-body Source: MGI
Keywordsi
Molecular function | Hydrolase |
Biological process | Nonsense-mediated mRNA decay |
Enzyme and pathway databases
Reactomei | R-MMU-430039, mRNA decay by 5' to 3' exoribonuclease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Dcp1b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442404, Dcp1b |
VEuPathDBi | HostDB:ENSMUSG00000041477 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: MGI
- P-body Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000287718 | 2 – 578 | mRNA-decapping enzyme 1BAdd BLAST | 577 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 144 | PhosphoserineCombined sources | 1 | |
Modified residuei | 145 | PhosphoserineBy similarity | 1 | |
Modified residuei | 274 | PhosphoserineBy similarity | 1 | |
Modified residuei | 335 | PhosphoserineBy similarity | 1 | |
Modified residuei | 380 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q3U564 |
jPOSTi | Q3U564 |
MaxQBi | Q3U564 |
PaxDbi | Q3U564 |
PRIDEi | Q3U564 |
ProteomicsDBi | 279506 [Q3U564-1] 279507 [Q3U564-2] |
PTM databases
iPTMneti | Q3U564 |
PhosphoSitePlusi | Q3U564 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041477, Expressed in testis and 230 other tissues |
ExpressionAtlasi | Q3U564, baseline and differential |
Genevisiblei | Q3U564, MM |
Interactioni
Subunit structurei
Interacts with DCP1A.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108397 |
Miscellaneous databases
RNActi | Q3U564, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 187 – 222 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 246 – 265 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 202 – 222 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2868, Eukaryota |
GeneTreei | ENSGT00940000158409 |
HOGENOMi | CLU_030030_2_0_1 |
InParanoidi | Q3U564 |
PhylomeDBi | Q3U564 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR010334, Dcp1 IPR031953, mRNA_decap_C IPR011993, PH-like_dom_sf |
PANTHERi | PTHR16290, PTHR16290, 2 hits |
Pfami | View protein in Pfam PF06058, DCP1, 1 hit PF16741, mRNA_decap_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAAGGLP GKGHDISLAA LRRHDPYISR IVDVASQVAL YTFGHRANEW
60 70 80 90 100
EKTGVEGTLF VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQNPFL
110 120 130 140 150
LYRNGTLSIY GIWFYDKEEC QRIAKLMKNL TQSEQLKACH GAGSSPVTLS
160 170 180 190 200
SGEGQEVDIL QMLTKAKDEY TKCKTCSEPK QMTNSSAICD NPKLIKPVPV
210 220 230 240 250
RPSSSQRLQG PAPSKTSDPE PQHLSLTALF GKQDKAPCQE TVKPSRTFAH
260 270 280 290 300
HHHHHHQQQQ ETRPVHHGVA CSLSCEEPRK LSLPVEKQLC PAIQKLMLGS
310 320 330 340 350
PGLHPLPQHP EQWSCKSGSP SPAGGILPGP VQLGSPWNGR VAHCTQSTCR
360 370 380 390 400
GHKLLEQLQG APGAVHKYNP CAPTGPAVAT QVAPGQSVAQ SQLVYFSGPL
410 420 430 440 450
QPPAPGHQAL RKEQGALPAQ AVSLSGSQES SPTVLPTQEL LRKLQVVHQE
460 470 480 490 500
QQAAPRPALA ARFPVSAQGS GTEKPLEAWV SKTASMEKQA PLLQSTCAPL
510 520 530 540 550
RETDNGLMAL GGQELPAASS NLLLPLQNWE SSTVASRPLT RLQLQEALLN
560 570
LIQNDDNFLS IIYEAYLFSV TQAAMRTT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB9EIX0 | B9EIX0_MOUSE | 5'-(N(7)-methylguanosine 5'-triphos... | Dcp1b | 578 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025609 | 495 – 527 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK050548 mRNA Translation: BAE20676.1 AK153860 mRNA Translation: BAE32216.1 BC141163 mRNA Translation: AAI41164.1 |
CCDSi | CCDS39610.1 [Q3U564-1] |
Genome annotation databases
Ensembli | ENSMUST00000073909; ENSMUSP00000073568; ENSMUSG00000041477 [Q3U564-2] |
UCSCi | uc009dly.2, mouse [Q3U564-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK050548 mRNA Translation: BAE20676.1 AK153860 mRNA Translation: BAE32216.1 BC141163 mRNA Translation: AAI41164.1 |
CCDSi | CCDS39610.1 [Q3U564-1] |
3D structure databases
AlphaFoldDBi | Q3U564 |
SMRi | Q3U564 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108397 |
PTM databases
iPTMneti | Q3U564 |
PhosphoSitePlusi | Q3U564 |
Proteomic databases
EPDi | Q3U564 |
jPOSTi | Q3U564 |
MaxQBi | Q3U564 |
PaxDbi | Q3U564 |
PRIDEi | Q3U564 |
ProteomicsDBi | 279506 [Q3U564-1] 279507 [Q3U564-2] |
Protocols and materials databases
Antibodypediai | 22113, 155 antibodies from 25 providers |
Genome annotation databases
Ensembli | ENSMUST00000073909; ENSMUSP00000073568; ENSMUSG00000041477 [Q3U564-2] |
UCSCi | uc009dly.2, mouse [Q3U564-2] |
Organism-specific databases
MGIi | MGI:2442404, Dcp1b |
VEuPathDBi | HostDB:ENSMUSG00000041477 |
Phylogenomic databases
eggNOGi | KOG2868, Eukaryota |
GeneTreei | ENSGT00940000158409 |
HOGENOMi | CLU_030030_2_0_1 |
InParanoidi | Q3U564 |
PhylomeDBi | Q3U564 |
Enzyme and pathway databases
Reactomei | R-MMU-430039, mRNA decay by 5' to 3' exoribonuclease |
Miscellaneous databases
ChiTaRSi | Dcp1b, mouse |
PROi | PR:Q3U564 |
RNActi | Q3U564, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041477, Expressed in testis and 230 other tissues |
ExpressionAtlasi | Q3U564, baseline and differential |
Genevisiblei | Q3U564, MM |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR010334, Dcp1 IPR031953, mRNA_decap_C IPR011993, PH-like_dom_sf |
PANTHERi | PTHR16290, PTHR16290, 2 hits |
Pfami | View protein in Pfam PF06058, DCP1, 1 hit PF16741, mRNA_decap_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCP1B_MOUSE | |
Accessioni | Q3U564Primary (citable) accession number: Q3U564 Secondary accession number(s): B2RUI2, Q3V333 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families