UniProtKB - Q3U4X8 (Q3U4X8_MOUSE)
Protein
DNA ligase
Gene
Lig1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotationARBA annotation EC:6.5.1.1
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: InterPro
- DNA ligase (ATP) activity Source: UniProtKB-EC
GO - Biological processi
- base-excision repair Source: Ensembl
- DNA biosynthetic process Source: InterPro
- DNA recombination Source: UniProtKB-KW
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | LigaseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Lig1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101789, Lig1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000056394, Expressed in undifferentiated genital tubercle and 324 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 662 – 798 | DNA_LIGASE_A3InterPro annotationAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 213 | DisorderedSequence analysisAdd BLAST | 213 | |
Regioni | 252 – 282 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 895 – 932 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 30 – 54 | PolyampholyteSequence analysisAdd BLAST | 25 | |
Compositional biasi | 98 – 129 | PolarSequence analysisAdd BLAST | 32 | |
Compositional biasi | 144 – 196 | PolyampholyteSequence analysisAdd BLAST | 53 | |
Compositional biasi | 254 – 274 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 899 – 925 | PolarSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000157783 |
HOGENOMi | CLU_005138_0_2_1 |
OMAi | PYPDWKP |
OrthoDBi | 274264at2759 |
TreeFami | TF300342 |
Family and domain databases
Gene3Di | 1.10.3260.10, 1 hit |
InterProi | View protein in InterPro IPR000977, DNA_ligase_ATP-dep IPR012309, DNA_ligase_ATP-dep_C IPR012310, DNA_ligase_ATP-dep_cent IPR016059, DNA_ligase_ATP-dep_CS IPR012308, DNA_ligase_ATP-dep_N IPR036599, DNA_ligase_N_sf IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF04679, DNA_ligase_A_C, 1 hit PF01068, DNA_ligase_A_M, 1 hit PF04675, DNA_ligase_A_N, 1 hit |
SUPFAMi | SSF117018, SSF117018, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00574, dnl1, 1 hit |
PROSITEi | View protein in PROSITE PS00697, DNA_LIGASE_A1, 1 hit PS00333, DNA_LIGASE_A2, 1 hit PS50160, DNA_LIGASE_A3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q3U4X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKKEQERKG ETSAANMQRS IMSFFQPTKE GKAKKPEKET PSSIREKEPP
60 70 80 90 100
PKVALKERNQ VVPESDSPVK RTGRKVAQVL SCEGEDEDEA PGTPKVQKPV
110 120 130 140 150
SDSEQSSPPS PDTCPENSPV FNCSSPMDIS PSGFPKRRTA RKQLPKRTIQ
160 170 180 190 200
DTLEEQNEDK TKTAKKRKKE EETPKESLAE AEDVKQKEEK EGDQLIVPSE
210 220 230 240 250
PTKSPESVTL TKTENIPVCK AGVKLKPQEE EQSKPPARGA KTLSSFFTPR
260 270 280 290 300
KPAVKTEVKQ EESGTLRKEE TKGTLDPANY NPSKNNYHPI EDACWKHGQK
310 320 330 340 350
VPFLAVARTF EKIEEVSARL KMVETLSNLL RSVVALSPPD LLPVLYLSLN
360 370 380 390 400
RLGPPQQGLE LGVGDGVLLK AVAQATGRQL ESIRAEVAEK GDVGLVAENS
410 420 430 440 450
RSTQRLMLPP PPLTISGVFT KFCDIARLTG SASMAKKMDI IKGLFVACRH
460 470 480 490 500
SEARYIARSL SGRLRLGLAE QSVLAALAQA VSLTPPGQEF PTAVVDAGKG
510 520 530 540 550
KTAEARKMWL EEQGMILKQT FCEVPDLDRI IPVLLEHGLE RLPEHCKLSP
560 570 580 590 600
GVPLKPMLAH PTRGVSEVLK RFEEVDFTCE YKYDGQRAQI HVLEGGEVKI
610 620 630 640 650
FSRNQEDNTG KYPDIISRIP KIKHPSVTSF ILDTEAVAWD REKKQIQPFQ
660 670 680 690 700
VLTTRKRKEV DASEIQVQVC LYAFDLIYLN GESLVRQPLS RRRQLLRENF
710 720 730 740 750
VETEGEFVFT TSLDTKDTEQ IAEFLEQSVK DSCEGLMVKT LDVDATYEIA
760 770 780 790 800
KRSHNWLKLK KDYLDGVGDT LDLVVIGAYL GRGKRAGRYG GFLLAAYDEE
810 820 830 840 850
SEELQAICKL GTGFSDEELE EHHQSLQALV LPTPRPYVRI DGAVAPDHWL
860 870 880 890 900
DPSIVWEVKC ADLSLSPIYP AARGLVDKEK GISLRFPRFI RVRKDKQPEQ
910 920 930
ATTSNQVASL YRKQSQIQNQ QSSDLDSDVE DY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP37913 | DNLI1_MOUSE | DNA ligase 1 | Lig1 Lig-1 | 916 | Annotation score: | ||
V9GWZ4 | V9GWZ4_MOUSE | DNA ligase 1 | Lig1 | 313 | Annotation score: | ||
D3YUW4 | D3YUW4_MOUSE | DNA ligase 1 | Lig1 | 225 | Annotation score: | ||
E9PV36 | E9PV36_MOUSE | DNA ligase 1 | Lig1 | 270 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC161792 Genomic DNA No translation available. BC138541 mRNA Translation: AAI38542.1 BC138542 mRNA Translation: AAI38543.1 AK153993 mRNA Translation: BAE32302.1 |
RefSeqi | NP_001076657.1, NM_001083188.1 NP_001186239.1, NM_001199310.1 NP_034845.2, NM_010715.2 |
Genome annotation databases
Ensembli | ENSMUST00000098814; ENSMUSP00000096411; ENSMUSG00000056394 ENSMUST00000165964; ENSMUSP00000126525; ENSMUSG00000056394 ENSMUST00000177588; ENSMUSP00000136972; ENSMUSG00000056394 |
GeneIDi | 16881 |
KEGGi | mmu:16881 |
UCSCi | uc009ffq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC161792 Genomic DNA No translation available. BC138541 mRNA Translation: AAI38542.1 BC138542 mRNA Translation: AAI38543.1 AK153993 mRNA Translation: BAE32302.1 |
RefSeqi | NP_001076657.1, NM_001083188.1 NP_001186239.1, NM_001199310.1 NP_034845.2, NM_010715.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 334368 |
Protocols and materials databases
Antibodypediai | 18267, 515 antibodies |
DNASUi | 16881 |
Genome annotation databases
Ensembli | ENSMUST00000098814; ENSMUSP00000096411; ENSMUSG00000056394 ENSMUST00000165964; ENSMUSP00000126525; ENSMUSG00000056394 ENSMUST00000177588; ENSMUSP00000136972; ENSMUSG00000056394 |
GeneIDi | 16881 |
KEGGi | mmu:16881 |
UCSCi | uc009ffq.1, mouse |
Organism-specific databases
CTDi | 3978 |
MGIi | MGI:101789, Lig1 |
Phylogenomic databases
GeneTreei | ENSGT00940000157783 |
HOGENOMi | CLU_005138_0_2_1 |
OMAi | PYPDWKP |
OrthoDBi | 274264at2759 |
TreeFami | TF300342 |
Miscellaneous databases
BioGRID-ORCSi | 16881, 4 hits in 48 CRISPR screens |
ChiTaRSi | Lig1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000056394, Expressed in undifferentiated genital tubercle and 324 other tissues |
Family and domain databases
Gene3Di | 1.10.3260.10, 1 hit |
InterProi | View protein in InterPro IPR000977, DNA_ligase_ATP-dep IPR012309, DNA_ligase_ATP-dep_C IPR012310, DNA_ligase_ATP-dep_cent IPR016059, DNA_ligase_ATP-dep_CS IPR012308, DNA_ligase_ATP-dep_N IPR036599, DNA_ligase_N_sf IPR012340, NA-bd_OB-fold |
Pfami | View protein in Pfam PF04679, DNA_ligase_A_C, 1 hit PF01068, DNA_ligase_A_M, 1 hit PF04675, DNA_ligase_A_N, 1 hit |
SUPFAMi | SSF117018, SSF117018, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00574, dnl1, 1 hit |
PROSITEi | View protein in PROSITE PS00697, DNA_LIGASE_A1, 1 hit PS00333, DNA_LIGASE_A2, 1 hit PS50160, DNA_LIGASE_A3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U4X8_MOUSE | |
Accessioni | Q3U4X8Primary (citable) accession number: Q3U4X8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |