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Protein

IGF-like family receptor 1

Gene

Igflr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable cell membrane receptor for the IGF-like family protein IGFL.1 Publication

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
IGF-like family receptor 1
Alternative name(s):
Transmembrane protein 149
Gene namesi
Name:Igflr1
Synonyms:Tmem149
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3655979 Igflr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 163ExtracellularSequence analysisAdd BLAST143
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 345CytoplasmicSequence analysisAdd BLAST161

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029035821 – 345IGF-like family receptor 1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3U4N7
PRIDEiQ3U4N7

PTM databases

PhosphoSitePlusiQ3U4N7

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in lymph node. Highly expressed in T-cells and monocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000036826 Expressed in 20 organ(s), highest expression level in bone marrow
CleanExiMM_TMEM149
MM_U2AF1L4
ExpressionAtlasiQ3U4N7 baseline
GenevisibleiQ3U4N7 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IgflQ6B9Z03EBI-3870498,EBI-3870418

Protein-protein interaction databases

IntActiQ3U4N7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ3U4N7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJZ Eukaryota
ENOG410YY5D LUCA
GeneTreeiENSGT00390000005702
HOVERGENiHBG099100
InParanoidiQ3U4N7
OMAiPYPGLVC
PhylomeDBiQ3U4N7
TreeFamiTF338761

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
SUPFAMiSSF47986 SSF47986, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U4N7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPSWLLWTV AVAVLLLTRA ASMEASSFCG HLEYWNSDKR CCSRCLQRFG
60 70 80 90 100
PPACPDHEFT ENCGLNDFGD TVAHPFKKCS PGYCNPNGTE LCSQCSSGAA
110 120 130 140 150
AAPAHVESPG RTHKQCRKKP VPPKDVCPLK PEDAGASSSP GRWSLGQTTK
160 170 180 190 200
NEVSSRPGFV SASVLPLAVL PLLLVLLLIL AVVLLSLFKR KVRSRPGSSS
210 220 230 240 250
AFGDPSTSLH YWPCPGTLEV LESRNRGKAN LLQLSSWELQ GLASQPLSLL
260 270 280 290 300
LDELEVLEEL IMLLDPEPGP SGSTAYGTTR HLAARYGLPA TWSTFAYSLR
310 320 330 340
PSRSPLRALI EMVVAREPSA TLGQFGTYLA QLGRTDALQV LSKLG
Length:345
Mass (Da):37,172
Last modified:October 11, 2005 - v1
Checksum:iB66AF0D33849BE9A
GO
Isoform 2 (identifier: Q3U4N7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):37,044
Checksum:iB9A45D2AD1383D7D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0U5E9Q0U5_MOUSE
IGF-like family receptor 1
Igflr1 Tmem149
365Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156R → Q in AAH19733 (PubMed:15489334).Curated1
Sequence conflicti197G → S in AAH19733 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026146118Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154129 mRNA Translation: BAE32394.1
BC019733 mRNA Translation: AAH19733.1
CCDSiCCDS39886.1 [Q3U4N7-1]
RefSeqiNP_663555.2, NM_145580.2 [Q3U4N7-1]
UniGeneiMm.333757

Genome annotation databases

EnsembliENSMUST00000043850; ENSMUSP00000042312; ENSMUSG00000036826 [Q3U4N7-1]
GeneIDi101883
KEGGimmu:101883
UCSCiuc009gfb.1 mouse [Q3U4N7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154129 mRNA Translation: BAE32394.1
BC019733 mRNA Translation: AAH19733.1
CCDSiCCDS39886.1 [Q3U4N7-1]
RefSeqiNP_663555.2, NM_145580.2 [Q3U4N7-1]
UniGeneiMm.333757

3D structure databases

ProteinModelPortaliQ3U4N7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3U4N7, 1 interactor

PTM databases

PhosphoSitePlusiQ3U4N7

Proteomic databases

PaxDbiQ3U4N7
PRIDEiQ3U4N7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043850; ENSMUSP00000042312; ENSMUSG00000036826 [Q3U4N7-1]
GeneIDi101883
KEGGimmu:101883
UCSCiuc009gfb.1 mouse [Q3U4N7-1]

Organism-specific databases

CTDi79713
MGIiMGI:3655979 Igflr1

Phylogenomic databases

eggNOGiENOG410IKJZ Eukaryota
ENOG410YY5D LUCA
GeneTreeiENSGT00390000005702
HOVERGENiHBG099100
InParanoidiQ3U4N7
OMAiPYPGLVC
PhylomeDBiQ3U4N7
TreeFamiTF338761

Miscellaneous databases

PROiPR:Q3U4N7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036826 Expressed in 20 organ(s), highest expression level in bone marrow
CleanExiMM_TMEM149
MM_U2AF1L4
ExpressionAtlasiQ3U4N7 baseline
GenevisibleiQ3U4N7 MM

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
SUPFAMiSSF47986 SSF47986, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIGFR1_MOUSE
AccessioniPrimary (citable) accession number: Q3U4N7
Secondary accession number(s): Q8VE58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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