UniProtKB - Q3U4I6 (Q3U4I6_MOUSE)
Protein
C-domain 1
Gene
Tnf
Organism
Mus musculus (Mouse)
Status
Functioni
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- tumor necrosis factor receptor binding Source: InterPro
GO - Biological processi
- immune response Source: InterPro
Keywordsi
Molecular function | CytokineARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: C-domain 1ARBA annotationAlternative name(s): C-domain 2ARBA annotation CachectinARBA annotation Intracellular domain 1ARBA annotation Intracellular domain 2ARBA annotation N-terminal fragmentARBA annotation TNF-alphaARBA annotation Tumor necrosis factorARBA annotation Tumor necrosis factor ligand superfamily member 2ARBA annotation Tumor necrosis factor, membrane formARBA annotation Tumor necrosis factor, soluble formARBA annotation |
Gene namesi | Name:TnfImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:104798, Tnf |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Extracellular region or secreted
- Secreted ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 31 – 56 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Membrane, SecretedARBA annotationPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, Lipoprotein, MyristateARBA annotationInteractioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- tumor necrosis factor receptor binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 89 – 219 | TNF_2InterPro annotationAdd BLAST | 131 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 82 – 102 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the tumor necrosis factor family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Signal-anchorARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U4I6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTESMIRDV ELAEEALPQE MGGFQNSRRC LCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LNFGVIGPQR DEKFPNGLPL ISSMAQTLTL TNHQVEEQLE WLSQRANALL
110 120 130 140 150
ANGMDLKDNQ LVVPADGLYL VYSQVLFKGQ GCPDYVLLTH AVSRFAISYQ
160 170 180 190 200
EKVNLLSAVK SPCPKDTPEG AELKPWYEPI YLGGVFQLEK GDQLSAEVNL
210
PKYLDFAESG QVYFGVIAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK154223 mRNA Translation: BAE32445.1 |
Genome annotation databases
UCSCi | uc012arb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK154223 mRNA Translation: BAE32445.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
UCSCi | uc012arb.2, mouse |
Organism-specific databases
MGIi | MGI:104798, Tnf |
Miscellaneous databases
ChiTaRSi | Tnf, mouse |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U4I6_MOUSE | |
Accessioni | Q3U4I6Primary (citable) accession number: Q3U4I6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | October 7, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |