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Protein

Lipase member N

Gene

Lipn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175NucleophileBy similarity1
Active sitei346Charge relay systemPROSITE-ProRule annotation1
Active sitei375Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Protein family/group databases

ESTHERimouse-LIPN Acidic_Lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member N (EC:3.1.1.-)
Alternative name(s):
Lipase-like abhydrolase domain-containing protein 4
Gene namesi
Name:Lipn
Synonyms:Lipl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1917416 Lipn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028683220 – 400Lipase member NAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi249 ↔ 258By similarity
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3U4B4
PRIDEiQ3U4B4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024770 Expressed in 13 organ(s), highest expression level in zone of skin
CleanExiMM_LIPN
ExpressionAtlasiQ3U4B4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025682

Structurei

3D structure databases

ProteinModelPortaliQ3U4B4
SMRiQ3U4B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 381AB hydrolase-1Sequence analysisAdd BLAST301

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00550000074328
HOGENOMiHOG000240694
HOVERGENiHBG006265
InParanoidiQ3U4B4
OMAiMQHALFA
OrthoDBiEOG091G09AX
PhylomeDBiQ3U4B4
TreeFamiTF315485

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR025483 Lipase_euk
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q3U4B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMMWLFLTT ACLIPGTLSA GGFLDFENKV NPEVWMNASE IIMYNGYPSE
60 70 80 90 100
EYDVTTADGY ILAINRIPHG RAQTGQTGPR PVVYMQHALF ADNAYWLENF
110 120 130 140 150
ANGSLGFILA DAGYDVWMGN SRGNTWSRRH KTLSANEEKF WAFSFNEMAK
160 170 180 190 200
YDLPGIIDFI VNKTGQEKLY FIGHSLGTTI GFVAFSTMPE LAQRIKMNFA
210 220 230 240 250
LGPVISFKYP TSVFTNLFLL PKSIIKLVFG TKGVLLEDKN ARMSFITFCN
260 270 280 290 300
QKLLQPLCSE FMSLWAGFNK KNMNMSRLDV YMAHAPTGSS IQNMLHIKQL
310 320 330 340 350
YRSDEFRAYD WGSEAENMNH YNQSYPPLYD LTAMKVPTAI WAGGHDVLVT
360 370 380 390 400
PQDVARILPQ ITNLRYFKQF PDWNHFDFVW GLDAPQRLYS KIISLMKEYF
Length:400
Mass (Da):45,744
Last modified:October 11, 2005 - v1
Checksum:i6C5A5B201EA5905A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVB0D3YVB0_MOUSE
Lipase member N
Lipn
180Annotation score:
D6RJJ5D6RJJ5_MOUSE
Lipase member N
Lipn
89Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154333 mRNA Translation: BAE32519.1
CCDSiCCDS37962.1
RefSeqiNP_081616.1, NM_027340.2
XP_006527396.1, XM_006527333.2
UniGeneiMm.75602

Genome annotation databases

EnsembliENSMUST00000025682; ENSMUSP00000025682; ENSMUSG00000024770
GeneIDi70166
KEGGimmu:70166
UCSCiuc008hfz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLIPN_MOUSE
AccessioniPrimary (citable) accession number: Q3U4B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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