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Entry version 89 (08 May 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Kielin/chordin-like protein

Gene

Kcp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin/chordin-like protein 1
Short name:
KCP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kcp
Synonyms:Crim2, Kcp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2141640 Kcp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031858722 – 1550Kielin/chordin-like proteinAdd BLAST1529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1236 ↔ 1244PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3U492

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3U492

PRoteomics IDEntifications database

More...
PRIDEi
Q3U492

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3U492

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3U492

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At 9.5 dpc the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as 9 dpc in the intermediate mesoderm. By 10 dpc, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At 18.5 dpc, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By renal stresses.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000059022 Expressed in 158 organ(s), highest expression level in brain blood vessel

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3U492 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U492 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine-/threonine protein kinase domains. Also able to interact with activin-A and TGFB1.

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099135

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3U492

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 191VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini192 – 251VWFC 2PROSITE-ProRule annotationAdd BLAST60
Domaini253 – 312VWFC 3PROSITE-ProRule annotationAdd BLAST60
Domaini313 – 370VWFC 4PROSITE-ProRule annotationAdd BLAST58
Domaini371 – 425VWFC 5PROSITE-ProRule annotationAdd BLAST55
Domaini426 – 485VWFC 6PROSITE-ProRule annotationAdd BLAST60
Domaini486 – 544VWFC 7PROSITE-ProRule annotationAdd BLAST59
Domaini545 – 602VWFC 8PROSITE-ProRule annotationAdd BLAST58
Domaini603 – 661VWFC 9PROSITE-ProRule annotationAdd BLAST59
Domaini665 – 724VWFC 10PROSITE-ProRule annotationAdd BLAST60
Domaini725 – 781VWFC 11PROSITE-ProRule annotationAdd BLAST57
Domaini782 – 840VWFC 12PROSITE-ProRule annotationAdd BLAST59
Domaini841 – 902VWFC 13PROSITE-ProRule annotationAdd BLAST62
Domaini903 – 958VWFC 14PROSITE-ProRule annotationAdd BLAST56
Domaini959 – 1016VWFC 15PROSITE-ProRule annotationAdd BLAST58
Domaini1017 – 1084VWFC 16PROSITE-ProRule annotationAdd BLAST68
Domaini1085 – 1144VWFC 17PROSITE-ProRule annotationAdd BLAST60
Domaini1148 – 1208VWFC 18PROSITE-ProRule annotationAdd BLAST61
Domaini1213 – 1425VWFDPROSITE-ProRule annotationAdd BLAST213
Domaini1489 – 1542TILAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili60 – 92Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
ENOG410XQ7V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160243

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168484

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3U492

Identification of Orthologs from Complete Genome Data

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OMAi
ACDGCEY

Database of Orthologous Groups

More...
OrthoDBi
1104860at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106451

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036084 Ser_inhib-like_sf
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00093 VWC, 9 hits
PF00094 VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 1 hit
SM00214 VWC, 17 hits
SM00215 VWC_out, 10 hits
SM00216 VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01208 VWFC_1, 13 hits
PS50184 VWFC_2, 14 hits
PS51233 VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U492-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGARAALLP LLLHLGSLAL AARGGEVSRE QPRLADAISQ QQAPSHSLVP
60 70 80 90 100
GETHQQQWCP LEERLERLEA EVTDLRKQNR ELQARVVQLE SCECWGPGHT
110 120 130 140 150
CPEGARWEPD ACTACVCRDG TAHCGPQPNL PHCRGCSHNG QSYGHGETFS
160 170 180 190 200
PDACTTCRCL AGTVQCQGPS CSELNCLESF IPPGECCPIC RPGCEYEGQL
210 220 230 240 250
HQEGSSFLSS SNPCLQCSCL RSLVRCVPVK CQPSPCLNPV PRLGHCCPVC
260 270 280 290 300
QASGCTEGNS HRDHGQEWTT PGDPCRICQC LEGHIQCRQR ECASLCPYPA
310 320 330 340 350
RPLPGTCCPV CDGCFLNGRE HSSGEPVGSQ DPCSSCRCTN GSVQCEPLPC
360 370 380 390 400
PPAPCRYPGR IPGQCCPVCD GCKYQGHEYR SQETFTLQEN GRCLRCVCQA
410 420 430 440 450
GEVSCEEQDC PVTPCVRSAS GPQLCSACVL NGEEFAEGIQ WEPDDQPCTS
460 470 480 490 500
CSCQDGVPVC RAVLCSPVPC QHPTQPPGAC CPSCDSCTYH SLVYANGQNF
510 520 530 540 550
TDVDSPCQTC YCEDGTVRCS LINCPFTTCA KPQNGPGQCC PKCPDCILEA
560 570 580 590 600
QVFVDGERFP HPRDPCQECW CQEGQAHCQL RACPSAPCVH PLPGTCCKND
610 620 630 640 650
CTGCAFGGKE YPNGADFPHP TDPCRLCRCL SGNVQCLARR CPPLSCPQPV
660 670 680 690 700
LTPGDCCPQC PDAPADCPQS GNMVPVRHQE HFFQPGDPCS RCLCLDGSVS
710 720 730 740 750
CQRLTCPPAP CAHPRRDACC PSCDGCLYQG KEFASGERFP SPNVACHVCL
760 770 780 790 800
CWEGSVKCEP RTCAPAQCPF PTREDCCPAC DSCDYLGVSY LSSQEFPDPR
810 820 830 840 850
EACNLCTCLG GFVTCTRRPC EPPACSHPLI VPEHCCPTCQ GCLYHGITAA
860 870 880 890 900
LGETLPDPLD PTCSLCTCEE GSMRCQKKPC PPAPCAHPSP GPCFCPVCRS
910 920 930 940 950
CLSQGREHQD GEEFEGPEGS CERCRCLAGQ VSCTRLQCPS LPCLHQVTEP
960 970 980 990 1000
GTCCPRCTGC LARGEEHPEG SSWVPADSPC SSCMCHKGII TCAQVQCVSA
1010 1020 1030 1040 1050
CIWPQEGPSD CCPQCSGCEH GGRKYEPGES FQPGADPCEV CICKQKREGP
1060 1070 1080 1090 1100
PSLHCSRRQC PSLVGCPPSQ LLPPGPQHCC PTCAQALSNC TEDLVGSELV
1110 1120 1130 1140 1150
PPDPCYTCQC QDLTWLCTHR ACPELSCPLW ERHTTPGSCC PVCKDPTQSC
1160 1170 1180 1190 1200
MHQGRWVASG EQWAVDACTS CSCVAGTVHC QTQRCRKLAC SRDEVPALSP
1210 1220 1230 1240 1250
GSCCLRCLPR PASCMAFGDP HYRTFDGRLL HFQGSCSYVL AKDCHGEDFS
1260 1270 1280 1290 1300
VHVTNDDRGR RGVAWTQEVA VLLGTVAVRL LQGRTVMVDQ HTVTLPFLRE
1310 1320 1330 1340 1350
PLLYIELRGH TVILHAQPGL QVLWDGQSQV EVRVPSSYRG QTCGLCGNFN
1360 1370 1380 1390 1400
GFAQDDLQGP DGRLLPTEAS FGNSWKVPKG LGPGRPCSAG REVDPCRAAG
1410 1420 1430 1440 1450
YRARREANAR CGILKTSPFS HCHAVVPPEP FFAACVYDLC ACGPGSSSDT
1460 1470 1480 1490 1500
CLCDALEAYA SHCRQAGVTP VWRGPTLCVV GCPVDRGFVF DECGPPCPRT
1510 1520 1530 1540 1550
CFNRHIPLGE LAAHCVRPCV PGCQCPAGLV EHEGHCISPE VCPPVLLTGD
Length:1,550
Mass (Da):166,628
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E6630EDA239D744
GO
Isoform 2 (identifier: Q3U492-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1255: SVHVTN → RWTSTQ
     1256-1550: Missing.

Note: No experimental confirmation available.
Show »
Length:1,255
Mass (Da):135,115
Checksum:i01A83D89AB0109E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QNB3E9QNB3_MOUSE
Kielin/chordin-like protein
Kcp
1,254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYL0E0CYL0_MOUSE
Kielin/chordin-like protein
Kcp
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UH68F6UH68_MOUSE
Kielin/chordin-like protein
Kcp
359Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B5X1F7B5X1_MOUSE
Kielin/chordin-like protein
Kcp
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7DED4F7DED4_MOUSE
Kielin/chordin-like protein
Kcp
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385F → L in AAX77677 (PubMed:15793581).Curated1
Sequence conflicti829L → F in BAE32541 (PubMed:16141072).Curated1
Sequence conflicti1045Missing in AAX77677 (PubMed:15793581).Curated1
Sequence conflicti1147T → N in BAE32541 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312321250 – 1255SVHVTN → RWTSTQ in isoform 2. 1 Publication6
Alternative sequenceiVSP_0312331256 – 1550Missing in isoform 2. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY884211 mRNA Translation: AAX77677.1
AK154369 mRNA Translation: BAE32541.1
AC079276 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57415.1 [Q3U492-1]

NCBI Reference Sequences

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RefSeqi
NP_001025156.3, NM_001029985.4 [Q3U492-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000078112; ENSMUSP00000077251; ENSMUSG00000059022 [Q3U492-2]
ENSMUST00000101614; ENSMUSP00000099135; ENSMUSG00000059022 [Q3U492-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
333088

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:333088

UCSC genome browser

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UCSCi
uc009bdt.2 mouse [Q3U492-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884211 mRNA Translation: AAX77677.1
AK154369 mRNA Translation: BAE32541.1
AC079276 Genomic DNA No translation available.
CCDSiCCDS57415.1 [Q3U492-1]
RefSeqiNP_001025156.3, NM_001029985.4 [Q3U492-1]

3D structure databases

SMRiQ3U492
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099135

PTM databases

iPTMnetiQ3U492
PhosphoSitePlusiQ3U492

Proteomic databases

MaxQBiQ3U492
PaxDbiQ3U492
PRIDEiQ3U492

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078112; ENSMUSP00000077251; ENSMUSG00000059022 [Q3U492-2]
ENSMUST00000101614; ENSMUSP00000099135; ENSMUSG00000059022 [Q3U492-1]
GeneIDi333088
KEGGimmu:333088
UCSCiuc009bdt.2 mouse [Q3U492-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
375616
MGIiMGI:2141640 Kcp

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
ENOG410XQ7V LUCA
GeneTreeiENSGT00940000160243
HOGENOMiHOG000168484
InParanoidiQ3U492
OMAiACDGCEY
OrthoDBi1104860at2759
TreeFamiTF106451

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Kcp mouse

Protein Ontology

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PROi
PR:Q3U492

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000059022 Expressed in 158 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiQ3U492 baseline and differential
GenevisibleiQ3U492 MM

Family and domain databases

InterProiView protein in InterPro
IPR036084 Ser_inhib-like_sf
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF00093 VWC, 9 hits
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM00832 C8, 1 hit
SM00214 VWC, 17 hits
SM00215 VWC_out, 10 hits
SM00216 VWD, 1 hit
SUPFAMiSSF57567 SSF57567, 1 hit
PROSITEiView protein in PROSITE
PS01208 VWFC_1, 13 hits
PS50184 VWFC_2, 14 hits
PS51233 VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U492
Secondary accession number(s): E9QJU0, Q56NI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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