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Protein
Submitted name:

Uncharacterized protein

Gene

Lrp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96828 Lrp1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi68 ↔ 80PROSITE-ProRule annotation
Disulfide bondi75 ↔ 93PROSITE-ProRule annotation
Disulfide bondi116 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 143PROSITE-ProRule annotation
Disulfide bondi147 ↔ 159PROSITE-ProRule annotation
Disulfide bondi154 ↔ 172PROSITE-ProRule annotation
Disulfide bondi214 ↔ 229PROSITE-ProRule annotation
Disulfide bondi257 ↔ 272PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q3U454

PRoteomics IDEntifications database

More...
PRIDEi
Q3U454

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U454 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3U454

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 354EGF-likeInterPro annotationAdd BLAST39
Domaini358 – 394EGF-likeInterPro annotationAdd BLAST37
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati441 – 487LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati488 – 530LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati531 – 577LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati578 – 622LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati623 – 663LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini671 – 711EGF-likeInterPro annotationAdd BLAST41
Repeati759 – 801LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati802 – 845LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati846 – 885LDL-receptor class BPROSITE-ProRule annotationAdd BLAST40
Repeati886 – 930LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Domaini981 – 1019EGF-likeInterPro annotationAdd BLAST39
Repeati1066 – 1108LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1109 – 1151LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1152 – 1195LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1196 – 1239LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Domaini1290 – 1327EGF-likeInterPro annotationAdd BLAST38
Repeati1385 – 1426LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1427 – 1457LDL-receptor class BPROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215 Eukaryota
ENOG410XP34 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG049163

KEGG Orthology (KO)

More...
KOi
K04550

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057 Ldl_recept_a, 7 hits
PF00058 Ldl_recept_b, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 5 hits
SM00192 LDLa, 8 hits
SM00135 LY, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 7 hits
PS51120 LDLRB, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q3U454-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ERWKCDGDND CLDNSDEAPA LCHQHTCPSD RFKCENNRCI PNRWLCDGDN
60 70 80 90 100
DCGNSEDESN ATCSARTCPP NQFSCASGRC IPISWTCDLD DDCGDRSDES
110 120 130 140 150
ASCAYPTCFP LTQFTCNNGR CININWRCDN DNDCGDNSDE AGCSHSCSST
160 170 180 190 200
QFKCNSGRCI PEHWTCDGDN DCGDYSDETH ANCTNQATRP PGGCHSDEFQ
210 220 230 240 250
CRLDGLCIPL RWRCDGDTDC MDSSDEKSCE GVTHVCDPNV KFGCKDSARC
260 270 280 290 300
ISKAWVCDGD SDCEDNSDEE NCEALACRPP SHPCANNTSV CLPPDKLCDG
310 320 330 340 350
KDDCGDGSDE GELCDQCSLN NGGCSHNCSV APGEGIVCSC PLGMELGSDN
360 370 380 390 400
HTCQIQSYCA KHLKCSQKCD QNKFSVKCSC YEGWVLEPDG ESCRSLDPFK
410 420 430 440 450
PFIIFSNRHE IRRIDLHKGD YSVLVPGLRN TIALDFHLSQ SALYWTDVVE
460 470 480 490 500
DKIYRGKLLD NGALTSFEVV IQYGLATPEG LAVDWIAGNI YWVESNLDQI
510 520 530 540 550
EVAKLDGTLR TTLLAGDIEH PRAIALDPRD GILFWTDWDA SLPRIEAASM
560 570 580 590 600
SGAGRRTIHR ETGSGGWPNG LTVDYLEKRI LWIDARSDAI YSARYDGSGH
610 620 630 640 650
MEVLRGHEFL SHPFAVTLYG GEVYWTDWRT NTLAKANKWT GHNVTVVQRT
660 670 680 690 700
NTQPFDLQVY HPSRQPMAPN PCEANGGRGP CSHLCLINYN RTVSCACPHL
710 720 730 740 750
MKLHKDNTTC YEFKKFLLYA RQMEIRGVDL DAPYYNYIIS FTVPDIDNVT
760 770 780 790 800
VLDYDAREQR VYWSDVRTQA IKRAFINGTG VETVVSADLP NAHGLAVDWV
810 820 830 840 850
SRNLFWTSYD TNKKQINVAR LDGSFKNAVV QGLEQPHGLV VHPLRGKLYW
860 870 880 890 900
TDGDNISMAN MDGSNHTLLF SGQKGPVGLA IDFPESKLYW ISSGNHTINR
910 920 930 940 950
CNLDGSELEV IDTMRSQLGK ATALAIMGDK LWWADQVSEK MGTCNKADGS
960 970 980 990 1000
GSVVLRNSTT LVMHMKVYDE SIQLEHEGTN PCSVNNGDCS QLCLPTSETT
1010 1020 1030 1040 1050
RSCMCTAGYS LRSGQQACEG VGSFLLYSVH EGIRGIPLDP NDKSDALVPV
1060 1070 1080 1090 1100
SGTSLAVGID FHAENDTIYW VDMGLSTISR AKRDQTWRED VVTNGIGRVE
1110 1120 1130 1140 1150
GIAVDWIAGN IYWTDQGFDV IEVARLNGSF RYVVISQGLD KPRAITVHPE
1160 1170 1180 1190 1200
KGYLFWTEWG HYPRIERSRL DGTERVVLVN VSISWPNGIS VDYQGGKLYW
1210 1220 1230 1240 1250
CDARMDKIER IDLETGENRE VVLSSNNMDM FSVSVFEDFI YWSDRTHANG
1260 1270 1280 1290 1300
SIKRGCKDNA TDSVPLRTGI GVQLKDIKVF NRDRQKGTNV CAVANGGCQQ
1310 1320 1330 1340 1350
LCLYRGGGQR ACACAHGMLA EDGASCREYA GYLLYSERTI LKSIHLSDER
1360 1370 1380 1390 1400
NLNAPVQPFE DPEHMKNVIA LAFDYRAGTS PGTPNRIFFS DIHFGNIQQI
1410 1420 1430 1440 1450
NDDGSGRTTI VENVGSVEGL AYHRGWDTLY WTSYTTSTIT RHTVDQTRPG

AFERETV
Length:1,457
Mass (Da):161,768
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67BA977DF1BA92F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1457Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK154429 mRNA Translation: BAE32580.1

NCBI Reference Sequences

More...
RefSeqi
NP_032538.2, NM_008512.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.271854

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16971

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154429 mRNA Translation: BAE32580.1
RefSeqiNP_032538.2, NM_008512.2
UniGeneiMm.271854

3D structure databases

ProteinModelPortaliQ3U454
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ3U454
PRIDEiQ3U454

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16971
KEGGimmu:16971

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4035
MGIiMGI:96828 Lrp1

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
ENOG410XP34 LUCA
HOVERGENiHBG049163
KOiK04550

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ3U454 MM

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.120.10.30, 4 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 7 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00192 LDLa, 8 hits
SM00135 LY, 16 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 7 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 7 hits
PS51120 LDLRB, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3U454_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U454
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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