Rara

Functionⁱ

GO - Molecular functionⁱ

alpha-actinin binding Source: Ensembl
chromatin DNA binding Source: Ensembl
histone deacetylase binding Source: Ensembl
mRNA 5'-UTR binding Source: Ensembl
nuclear receptor activity Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase A binding Source: Ensembl
protein kinase B binding Source: Ensembl
retinoic acid binding Source: Ensembl
retinoic acid-responsive element binding Source: Ensembl
signaling receptor binding Source: Ensembl
translation repressor activity, mRNA regulatory element binding Source: Ensembl
zinc ion binding Source: InterPro

GO - Biological processⁱ

apoptotic cell clearance Source: Ensembl
cellular response to estrogen stimulus Source: Ensembl
female pregnancy Source: Ensembl
hippocampus development Source: Ensembl
liver development Source: Ensembl
male gonad development Source: Ensembl
negative regulation of cell population proliferation Source: Ensembl
negative regulation of granulocyte differentiation Source: Ensembl
negative regulation of interferon-gamma production Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
negative regulation of tumor necrosis factor production Source: Ensembl
positive regulation of binding Source: Ensembl
positive regulation of cell cycle Source: Ensembl
positive regulation of cell population proliferation Source: Ensembl
positive regulation of interleukin-13 production Source: Ensembl
positive regulation of interleukin-4 production Source: Ensembl
positive regulation of interleukin-5 production Source: Ensembl
positive regulation of neuron differentiation Source: Ensembl
positive regulation of T-helper 2 cell differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
prostate gland development Source: Ensembl
protein phosphorylation Source: Ensembl
regulation of apoptotic process Source: Ensembl
regulation of myelination Source: Ensembl
regulation of synaptic plasticity Source: Ensembl
response to cytokine Source: Ensembl
response to estradiol Source: Ensembl
response to ethanol Source: Ensembl
response to retinoic acid Source: Ensembl
response to vitamin A Source: Ensembl
retinoic acid receptor signaling pathway Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:RaraImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:97856, Rara
VEuPathDBⁱ	HostDB:ENSMUSG00000037992

Keywords - Cellular componentⁱ

NucleusUniRule annotationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037992, Expressed in granulocyte and 240 other tissues
ExpressionAtlasⁱ	Q3U3R3, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

alpha-actinin binding Source: Ensembl
histone deacetylase binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase A binding Source: Ensembl
protein kinase B binding Source: Ensembl
signaling receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	Q3U3R3

BindingDBⁱ

Q3U3R3

Structureⁱ

3D structure databases

SMRⁱ	Q3U3R3
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	85 – 160	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	183 – 417	NR LBDInterPro annotationAdd BLAST		235

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	52 – 77	DisorderedSequence analysisAdd BLAST		26
Regionⁱ	420 – 462	DisorderedSequence analysisAdd BLAST		43

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	52 – 71	Polar residuesSequence analysisAdd BLAST		20
Compositional biasⁱ	447 – 462	Polar residuesSequence analysisAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotation

Keywords - Domainⁱ

Zinc-fingerUniRule annotationARBA annotation

Phylogenomic databases

HOGENOMⁱ	CLU_007368_18_2_1
OMAⁱ	PPYSYFF
Database of Orthologous Groups More...OrthoDBⁱ	1165737at2759
PhylomeDBⁱ	Q3U3R3

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3U3R3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTSLQHQLPV 
        60         70         80         90        100
SGYSTPSPAT IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY 
       110        120        130        140        150
GVSACEGCKG FFRRSIQKNM VYTCHRDKNC IINKVTRNRC QYCRLQKCFD 
       160        170        180        190        200
VGMSKESVRN DRNKKKKEAP KPECSESYTL TPEVGELIEK VRKAHQETFP 
       210        220        230        240        250
ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV EFAKQLPGFT 
       260        270        280        290        300
TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 
       310        320        330        340        350
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDKVDM 
       360        370        380        390        400
LQEPLLEALK VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM 
       410        420        430        440        450
EIPGSMPPLI QEMLENSEGL DTLSGQSGGG TRDGGGLAPP PGSCSPSLSP 
       460 
SSHRSSPATQ SP

Length:462

Mass (Da):50,735

Last modified:October 11, 2005 - v1

Checksum:ⁱ726F7799633A85AD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK042163 mRNA Translation: BAE20623.1 AK154623 mRNA Translation: BAE32722.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001170773.1, NM_001177302.1 NP_001170774.1, NM_001177303.1 NP_033050.2, NM_009024.2 XP_006532655.1, XM_006532592.3 XP_006532656.1, XM_006532593.2 XP_017169842.1, XM_017314353.1

Genome annotation databases

GeneIDⁱ	19401
KEGGⁱ	mmu:19401

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3U3R3	Retinoic acid receptor alpha		MOUSE		462	UniRef100_P11416
Uncharacterized protein		MOUSE		343

Protein	Similar proteins		Species	Score	Length	Source
Q3U3R3	Retinoic acid receptor alpha		MOUSE		462	UniRef90_P11416
Uncharacterized protein		MOUSE		343

Protein	Similar proteins		Species	Score	Length	Source
Q3U3R3	Retinoic acid receptor alpha	)	HUMAN		462	UniRef50_P10276
Retinoic acid receptor beta (Fragment)		NOTVI		158
Retinoic acid receptor alpha		MOUSE		462
Retinoic acid receptor alpha-A		DANRE		444
Retinoic acid receptor alpha		TAKRU		447
+541

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK042163 mRNA Translation: BAE20623.1 AK154623 mRNA Translation: BAE32722.1
RefSeqⁱ	NP_001170773.1, NM_001177302.1 NP_001170774.1, NM_001177303.1 NP_033050.2, NM_009024.2 XP_006532655.1, XM_006532592.3 XP_006532656.1, XM_006532593.2 XP_017169842.1, XM_017314353.1

3D structure databases

SMRⁱ	Q3U3R3
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	Q3U3R3

BindingDBⁱ

Q3U3R3

Protocols and materials databases

Antibodypediaⁱ	16473, 794 antibodies
The DNASU plasmid repository More...DNASUⁱ	19401

Genome annotation databases

GeneIDⁱ	19401
KEGGⁱ	mmu:19401

Organism-specific databases

CTDⁱ	5914
MGIⁱ	MGI:97856, Rara
VEuPathDBⁱ	HostDB:ENSMUSG00000037992

Phylogenomic databases

HOGENOMⁱ	CLU_007368_18_2_1
OMAⁱ	PPYSYFF
OrthoDBⁱ	1165737at2759
PhylomeDBⁱ	Q3U3R3

Miscellaneous databases

BioGRID-ORCSⁱ	19401, 2 hits in 63 CRISPR screens
ChiTaRSⁱ	Rara, mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037992, Expressed in granulocyte and 240 other tissues
ExpressionAtlasⁱ	Q3U3R3, baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3U3R3_MOUSE
Accessionⁱ	Q3U3R3Primary (citable) accession number: Q3U3R3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	September 29, 2021
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - Q3U3R3 (Q3U3R3_MOUSE)

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Uncharacterized protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ