Uncharacterized protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-actinin binding Source: Ensembl
• chromatin DNA binding Source: Ensembl
• drug binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• mRNA 5'-UTR binding Source: Ensembl
• nuclear receptor activity Source: Ensembl
• protein domain specific binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein kinase A binding Source: Ensembl
• protein kinase B binding Source: Ensembl
• retinoic acid binding Source: Ensembl
• retinoic acid-responsive element binding Source: Ensembl
• signaling receptor binding Source: Ensembl
• steroid hormone receptor activity Source: InterPro
• transcription coactivator activity Source: Ensembl
• transcription corepressor activity Source: Ensembl
• transcription factor binding Source: Ensembl
• translation repressor activity, mRNA regulatory element binding Source: Ensembl
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• apoptotic cell clearance Source: Ensembl
• cellular response to estrogen stimulus Source: Ensembl
• cellular response to retinoic acid Source: Ensembl
• female pregnancy Source: Ensembl
• hippocampus development Source: Ensembl
• liver development Source: Ensembl
• male gonad development Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of granulocyte differentiation Source: Ensembl
• negative regulation of interferon-gamma production Source: Ensembl
• negative regulation of transcription, DNA-templated Source: Ensembl
• negative regulation of tumor necrosis factor production Source: Ensembl
• positive regulation of binding Source: Ensembl
• positive regulation of cell cycle Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of interleukin-13 production Source: Ensembl
• positive regulation of interleukin-4 production Source: Ensembl
• positive regulation of interleukin-5 production Source: Ensembl
• positive regulation of neuron differentiation Source: Ensembl
• positive regulation of T-helper 2 cell differentiation Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• prostate gland development Source: Ensembl
• protein phosphorylation Source: Ensembl
• regulation of apoptotic process Source: Ensembl
• regulation of myelination Source: Ensembl
• regulation of synaptic plasticity Source: Ensembl
• response to cytokine Source: Ensembl
• response to estradiol Source: Ensembl
• response to ethanol Source: Ensembl
• response to vitamin A Source: Ensembl
• retinoic acid receptor signaling pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• alpha-actinin binding Source: Ensembl
• histone deacetylase binding Source: Ensembl
• protein domain specific binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• protein kinase A binding Source: Ensembl
• protein kinase B binding Source: Ensembl
• signaling receptor binding Source: Ensembl
• transcription factor binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTSLQHQLPV 
        60         70         80         90        100
SGYSTPSPAT IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY 
       110        120        130        140        150
GVSACEGCKG FFRRSIQKNM VYTCHRDKNC IINKVTRNRC QYCRLQKCFD 
       160        170        180        190        200
VGMSKESVRN DRNKKKKEAP KPECSESYTL TPEVGELIEK VRKAHQETFP 
       210        220        230        240        250
ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV EFAKQLPGFT 
       260        270        280        290        300
TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 
       310        320        330        340        350
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDKVDM 
       360        370        380        390        400
LQEPLLEALK VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM 
       410        420        430        440        450
EIPGSMPPLI QEMLENSEGL DTLSGQSGGG TRDGGGLAPP PGSCSPSLSP 
       460 
SSHRSSPATQ SP                                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ