UniProtKB - Q3U3R3 (Q3U3R3_MOUSE)
Protein
Submitted name:
Uncharacterized protein
Gene
Rara
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- chromatin DNA binding Source: Ensembl
- drug binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- mRNA 5'-UTR binding Source: Ensembl
- nuclear receptor activity Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein kinase A binding Source: Ensembl
- protein kinase B binding Source: Ensembl
- retinoic acid binding Source: Ensembl
- retinoic acid-responsive element binding Source: Ensembl
- signaling receptor binding Source: Ensembl
- steroid hormone receptor activity Source: InterPro
- transcription coactivator activity Source: Ensembl
- transcription corepressor activity Source: Ensembl
- transcription factor binding Source: Ensembl
- translation repressor activity, mRNA regulatory element binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic cell clearance Source: Ensembl
- cellular response to estrogen stimulus Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- female pregnancy Source: Ensembl
- hippocampus development Source: Ensembl
- liver development Source: Ensembl
- male gonad development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of granulocyte differentiation Source: Ensembl
- negative regulation of interferon-gamma production Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- negative regulation of tumor necrosis factor production Source: Ensembl
- positive regulation of binding Source: Ensembl
- positive regulation of cell cycle Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of interleukin-13 production Source: Ensembl
- positive regulation of interleukin-4 production Source: Ensembl
- positive regulation of interleukin-5 production Source: Ensembl
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of T-helper 2 cell differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- prostate gland development Source: Ensembl
- protein phosphorylation Source: Ensembl
- regulation of apoptotic process Source: Ensembl
- regulation of myelination Source: Ensembl
- regulation of synaptic plasticity Source: Ensembl
- response to cytokine Source: Ensembl
- response to estradiol Source: Ensembl
- response to ethanol Source: Ensembl
- response to vitamin A Source: Ensembl
- retinoic acid receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation |
Biological process | Transcription, Transcription regulationUniRule annotationSAAS annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:RaraImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97856 Rara |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationSAAS annotation
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear chromatin Source: Ensembl
Other locations
- dendrite Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusUniRule annotationSAAS annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000037992 Expressed in 214 organ(s), highest expression level in head |
Interactioni
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein kinase A binding Source: Ensembl
- protein kinase B binding Source: Ensembl
- signaling receptor binding Source: Ensembl
- transcription factor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 160 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 183 – 417 | NR LBDInterPro annotationAdd BLAST | 235 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationSAAS annotationPhylogenomic databases
eggNOGi | KOG3575 Eukaryota ENOG410XRZC LUCA |
HOVERGENi | HBG005606 |
KOi | K08527 |
OMAi | NNSSDQR |
OrthoDBi | 1165737at2759 |
Family and domain databases
Gene3Di | 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U3R3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTSLQHQLPV
60 70 80 90 100
SGYSTPSPAT IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY
110 120 130 140 150
GVSACEGCKG FFRRSIQKNM VYTCHRDKNC IINKVTRNRC QYCRLQKCFD
160 170 180 190 200
VGMSKESVRN DRNKKKKEAP KPECSESYTL TPEVGELIEK VRKAHQETFP
210 220 230 240 250
ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV EFAKQLPGFT
260 270 280 290 300
TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA
310 320 330 340 350
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDKVDM
360 370 380 390 400
LQEPLLEALK VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM
410 420 430 440 450
EIPGSMPPLI QEMLENSEGL DTLSGQSGGG TRDGGGLAPP PGSCSPSLSP
460
SSHRSSPATQ SP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK042163 mRNA Translation: BAE20623.1 AK154623 mRNA Translation: BAE32722.1 |
RefSeqi | NP_001170773.1, NM_001177302.1 NP_001170774.1, NM_001177303.1 NP_033050.2, NM_009024.2 XP_006532655.1, XM_006532592.3 XP_006532656.1, XM_006532593.2 XP_017169842.1, XM_017314353.1 |
UniGenei | Mm.439744 |
Genome annotation databases
GeneIDi | 19401 |
KEGGi | mmu:19401 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK042163 mRNA Translation: BAE20623.1 AK154623 mRNA Translation: BAE32722.1 |
RefSeqi | NP_001170773.1, NM_001177302.1 NP_001170774.1, NM_001177303.1 NP_033050.2, NM_009024.2 XP_006532655.1, XM_006532592.3 XP_006532656.1, XM_006532593.2 XP_017169842.1, XM_017314353.1 |
UniGenei | Mm.439744 |
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 19401 |
KEGGi | mmu:19401 |
Organism-specific databases
CTDi | 5914 |
MGIi | MGI:97856 Rara |
Phylogenomic databases
eggNOGi | KOG3575 Eukaryota ENOG410XRZC LUCA |
HOVERGENi | HBG005606 |
KOi | K08527 |
OMAi | NNSSDQR |
OrthoDBi | 1165737at2759 |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037992 Expressed in 214 organ(s), highest expression level in head |
Family and domain databases
Gene3Di | 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit |
PRINTSi | PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER |
SMARTi | View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit |
SUPFAMi | SSF48508 SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | Q3U3R3_MOUSE | |
Accessioni | Q3U3R3Primary (citable) accession number: Q3U3R3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 13, 2019 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |