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Entry version 93 (02 Dec 2020)
Sequence version 1 (11 Oct 2005)
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Protein

Protein FAM117B

Gene

Fam117b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM117B
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam117b
Synonyms:Als2cr13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920000, Fam117b

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995341 – 584Protein FAM117BAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei206PhosphoserineBy similarity1
Modified residuei215PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei340PhosphoserineCombined sources1
Modified residuei386PhosphoserineBy similarity1
Modified residuei444PhosphoserineCombined sources1
Modified residuei452PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3U3E2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3U3E2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3U3E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3U3E2

PeptideAtlas

More...
PeptideAtlasi
Q3U3E2

PRoteomics IDEntifications database

More...
PRIDEi
Q3U3E2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3U3E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3U3E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041040, Expressed in cumulus cell and 290 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U3E2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041671

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3U3E2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 95Gly-richAdd BLAST81
Compositional biasi133 – 141Poly-Pro9

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR2I, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033432_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3U3E2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHWPRDS

Database of Orthologous Groups

More...
OrthoDBi
1132072at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3U3E2

TreeFam database of animal gene trees

More...
TreeFami
TF333159

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026641, FAM117B
IPR026642, Glcci1/FAM117

The PANTHER Classification System

More...
PANTHERi
PTHR14972, PTHR14972, 1 hit
PTHR14972:SF6, PTHR14972:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15388, FAM117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3U3E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQRVRRNGS PTPAGALAGG AVGPPGGPGS RLQPMRATVP FQLKQQQQHG
60 70 80 90 100
SPTRGGGGGG NNGGNGGASG PSGGGGSGGP RTASRSTSPT RGGGGSAAAR
110 120 130 140 150
TSPTVATQTG ASVTSTRGTS PTRGTAPGAR SSPPRPQPPP PLLGTVSSPS
160 170 180 190 200
SSPTHLWPSE VIAAPPSARV RHRRRSPEQG RPSAEKRSPS APVCKAGDKT
210 220 230 240 250
HPPSSSSSSI IRRTSSLDTL AAPYLAGHWP RDIRGQAAPC MRDKATQTES
260 270 280 290 300
AWAEEYEKKK GSHKRSSSWG STEQLKEIAK LRQQLQRSKH SSRHHRDKER
310 320 330 340 350
QSPFHGNHAA INQSQAPAPK STLVPAGPIT KSSGSRFRNS VEGLNQEIEI
360 370 380 390 400
IIKETGEKEE QLIPQDIPDG HRAPPPLAQR SSSTRSIDTQ TPGGADKGSN
410 420 430 440 450
NSSRSQSVSP TSFLTISNEG SEESPCSADD LLADPRDKEN GNNSPLPKYA
460 470 480 490 500
TSPKPNNSYM FKREPPEGCE RVKVFEECSP KQLHEIPAFY CPDKNKVNFI
510 520 530 540 550
PKSGSAFCLV SILKPLLPTP DLTLKGSGHS LTVTTGMTTT LLQPISMASL
560 570 580
STNTEQERVS RGTSTVLPSA SLHAPPEPIE EAEG
Length:584
Mass (Da):61,345
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6925098BD41905AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QWW4M0QWW4_MOUSE
Protein FAM117B
Fam117b
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK154812 mRNA Translation: BAE32846.1
BC080299 mRNA Translation: AAH80299.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14986.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032814.1, NM_001037725.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000036540; ENSMUSP00000041671; ENSMUSG00000041040

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72750

UCSC genome browser

More...
UCSCi
uc011wlt.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154812 mRNA Translation: BAE32846.1
BC080299 mRNA Translation: AAH80299.2
CCDSiCCDS14986.1
RefSeqiNP_001032814.1, NM_001037725.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041671

PTM databases

iPTMnetiQ3U3E2
PhosphoSitePlusiQ3U3E2

Proteomic databases

EPDiQ3U3E2
jPOSTiQ3U3E2
MaxQBiQ3U3E2
PaxDbiQ3U3E2
PeptideAtlasiQ3U3E2
PRIDEiQ3U3E2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1012, 124 antibodies

Genome annotation databases

EnsembliENSMUST00000036540; ENSMUSP00000041671; ENSMUSG00000041040
GeneIDi72750
KEGGimmu:72750
UCSCiuc011wlt.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150864
MGIiMGI:1920000, Fam117b

Phylogenomic databases

eggNOGiENOG502QR2I, Eukaryota
GeneTreeiENSGT00950000183046
HOGENOMiCLU_033432_0_0_1
InParanoidiQ3U3E2
OMAiGHWPRDS
OrthoDBi1132072at2759
PhylomeDBiQ3U3E2
TreeFamiTF333159

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
72750, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fam117b, mouse

Protein Ontology

More...
PROi
PR:Q3U3E2
RNActiQ3U3E2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041040, Expressed in cumulus cell and 290 other tissues
GenevisibleiQ3U3E2, MM

Family and domain databases

InterProiView protein in InterPro
IPR026641, FAM117B
IPR026642, Glcci1/FAM117
PANTHERiPTHR14972, PTHR14972, 1 hit
PTHR14972:SF6, PTHR14972:SF6, 1 hit
PfamiView protein in Pfam
PF15388, FAM117, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF117B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U3E2
Secondary accession number(s): Q68EE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: December 2, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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