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Protein

Genetic suppressor element 1

Gene

Gse1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Genetic suppressor element 1
Gene namesi
Name:Gse1
Synonyms:Kiaa0182
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1098275 Gse1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629251 – 1213Genetic suppressor element 1Add BLAST1213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei84PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei305Asymmetric dimethylarginineBy similarity1
Modified residuei433PhosphothreonineBy similarity1
Modified residuei496N6-acetyllysineBy similarity1
Modified residuei739N6-acetyllysineBy similarity1
Modified residuei766PhosphoserineCombined sources1
Modified residuei826PhosphoserineBy similarity1
Modified residuei828PhosphoserineBy similarity1
Modified residuei857PhosphoserineBy similarity1
Modified residuei905PhosphothreonineBy similarity1
Modified residuei907PhosphoserineBy similarity1
Modified residuei1099PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ3U3C9
PaxDbiQ3U3C9
PeptideAtlasiQ3U3C9
PRIDEiQ3U3C9

PTM databases

iPTMnetiQ3U3C9
PhosphoSitePlusiQ3U3C9

Expressioni

Gene expression databases

BgeeiENSMUSG00000031822 Expressed in 236 organ(s), highest expression level in thymus
CleanExiMM_GSE1
ExpressionAtlasiQ3U3C9 baseline and differential
GenevisibleiQ3U3C9 MM

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034279

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili319 – 402Sequence analysisAdd BLAST84
Coiled coili1093 – 1197Sequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi649 – 673Pro-richAdd BLAST25
Compositional biasi745 – 748Poly-Arg4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGKK Eukaryota
ENOG410Z7HR LUCA
GeneTreeiENSGT00700000104539
HOGENOMiHOG000112825
HOVERGENiHBG079773
InParanoidiQ3U3C9
OMAiKPWEPFM
OrthoDBiEOG091G031Y
PhylomeDBiQ3U3C9
TreeFamiTF332496

Family and domain databases

InterProiView protein in InterPro
IPR022207 GSE-like
PfamiView protein in Pfam
PF12540 DUF3736, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U3C9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGMSHEPKS PSIGMLSTAT RTTATVNPLT PSPLNGALVP TGSPATSSTL
60 70 80 90 100
SAQAAPSSSF AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP
110 120 130 140 150
KRVPMGPIIV PPGGHSVPST PPVVTIAPTK TVNGVWRSES RQDSGSRGSS
160 170 180 190 200
SGRERLLVEP PLAQEKAAGP AIPSHLLSTP YPFGLSPGSV VQDSRFQPLN
210 220 230 240 250
LQRPVHHVVP PSTVTEDYLR SFRPYHTAED LRMSSLPPLG LDPATAAAYY
260 270 280 290 300
HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH
310 320 330 340 350
LSGVRYPPEL SHSSLAALHS ERMSSLSAER LQMDEELRRE RERERERERE
360 370 380 390 400
ADREREKERE REQREKEREK ELEREREKER ERELERQREQ RAREKELLAA
410 420 430 440 450
KALEPTTFLP VAELHGLRGH STEERPKPSE QLTPTRAEKL KDVGLQAPKP
460 470 480 490 500
VQHPLHPVPA PHHTVPSLIS SHGIFSLPGS SATTALLIQR TNEEEKWLAR
510 520 530 540 550
QRRLRQEKED RQSQVSEFRQ QVLEQHLDLG RPLVPTEAEH RPESTRPGTN
560 570 580 590 600
RHEQGSREPP QHFGGPPPLI SPKPQQHTVP TALWNPVSLM DNALETRRAE
610 620 630 640 650
SHSLHSHPTA FEPSRQAAVP LVKVERVYCS EKAEEPRKRE ATPLDKYQPP
660 670 680 690 700
PPPPPPREAG SLEPQTFPHG PGPFLTELEK STQTILGQQR PSLSQATSFG
710 720 730 740 750
ELSGPLKPGS PYCHPTARGP DPAYIYDEFL QQRRKLVSKL DLEERRRREA
760 770 780 790 800
QEKGYYYDLD DSYDESDEEE VRAHLRCVAE QPPLKLDTSS EKLEFLQLFG
810 820 830 840 850
LTTQQQKEEL VAQKRRKRRR MLRERSPSPP AVQCKRQTPS PRLALSTRYS
860 870 880 890 900
PDEMNNSPNF EEKRKFLTFF NLTHISAEKR KDKERLVEML RAMKQRALSA
910 920 930 940 950
ADSVTNSSRD SPPVSLSEPA TQPAPLETDQ PVGVPASLSD VPKTTETGRL
960 970 980 990 1000
EQLRPQELLR VQEPAPPSGE KARLSEAPGG KKSLSMLHYL RGAAPKDIPV
1010 1020 1030 1040 1050
PLSHSINGKS KPWEPFVAEE FAHQFHESVL QSTQKALQKH KGNSALLSAE
1060 1070 1080 1090 1100
QSHKVDTAIH YNIPELQSSS RVPLPQHNGQ QEPPMGRKGP PMQEADQDSE
1110 1120 1130 1140 1150
EDSEEDSEEE AEEAPRRQWQ GIEAIFEAYQ EHIEEQNLER QVLQTQCRRL
1160 1170 1180 1190 1200
EAQNYSLSLT AEQLSHSMAE LRSQKQKMVS ERERLQAELD HLRKCLALPT
1210
MHWPRGYFKG YPR
Length:1,213
Mass (Da):136,228
Last modified:November 28, 2006 - v2
Checksum:iCC844DBE6B2B9BA0
GO
Isoform 2 (identifier: Q3U3C9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MK → MFGLKPPLYYLP

Note: No experimental confirmation available.
Show »
Length:1,223
Mass (Da):137,389
Checksum:iC50EEEF9CE62CDAA
GO
Isoform 3 (identifier: Q3U3C9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: Missing.

Show »
Length:1,210
Mass (Da):135,911
Checksum:iDC48B1F73472AE7A
GO
Isoform 4 (identifier: Q3U3C9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-917: Missing.

Note: No experimental confirmation available.
Show »
Length:1,177
Mass (Da):132,299
Checksum:i4B765B87F2B3AD6B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QWG1M0QWG1_MOUSE
Genetic suppressor element 1
Gse1
729Annotation score:

Sequence cautioni

The sequence AAH43094 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC28215 differs from that shown. Reason: Frameshift at positions 26 and 168.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22T → A in BAE32859 (PubMed:16141072).Curated1
Sequence conflicti57Missing in BAE32859 (PubMed:16141072).Curated1
Sequence conflicti300H → R in BAE32859 (PubMed:16141072).Curated1
Sequence conflicti509E → K in BAE32859 (PubMed:16141072).Curated1
Sequence conflicti531R → W in BAE32859 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0218221 – 3Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_0218231 – 2MK → MFGLKPPLYYLP in isoform 2. 1 Publication2
Alternative sequenceiVSP_021824882 – 917Missing in isoform 4. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033263 mRNA Translation: BAC28215.1 Frameshift.
AK136004 mRNA Translation: BAE22769.1
AK154829 mRNA Translation: BAE32859.1
BC043094 mRNA Translation: AAH43094.1 Different initiation.
AK122216 mRNA Translation: BAC65498.1
L27155 mRNA No translation available.
CCDSiCCDS52687.1 [Q3U3C9-2]
CCDS52688.1 [Q3U3C9-1]
CCDS52689.1 [Q3U3C9-3]
RefSeqiNP_001139368.1, NM_001145896.1 [Q3U3C9-1]
NP_001139369.1, NM_001145897.1 [Q3U3C9-3]
NP_941073.2, NM_198671.2 [Q3U3C9-2]
UniGeneiMm.334856

Genome annotation databases

EnsembliENSMUST00000034279; ENSMUSP00000034279; ENSMUSG00000031822 [Q3U3C9-2]
ENSMUST00000118136; ENSMUSP00000112981; ENSMUSG00000031822 [Q3U3C9-1]
ENSMUST00000120493; ENSMUSP00000113577; ENSMUSG00000031822 [Q3U3C9-3]
GeneIDi382034
KEGGimmu:382034
UCSCiuc009nqz.2 mouse [Q3U3C9-2]
uc009nra.2 mouse [Q3U3C9-1]
uc009nrc.2 mouse [Q3U3C9-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033263 mRNA Translation: BAC28215.1 Frameshift.
AK136004 mRNA Translation: BAE22769.1
AK154829 mRNA Translation: BAE32859.1
BC043094 mRNA Translation: AAH43094.1 Different initiation.
AK122216 mRNA Translation: BAC65498.1
L27155 mRNA No translation available.
CCDSiCCDS52687.1 [Q3U3C9-2]
CCDS52688.1 [Q3U3C9-1]
CCDS52689.1 [Q3U3C9-3]
RefSeqiNP_001139368.1, NM_001145896.1 [Q3U3C9-1]
NP_001139369.1, NM_001145897.1 [Q3U3C9-3]
NP_941073.2, NM_198671.2 [Q3U3C9-2]
UniGeneiMm.334856

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034279

PTM databases

iPTMnetiQ3U3C9
PhosphoSitePlusiQ3U3C9

Proteomic databases

MaxQBiQ3U3C9
PaxDbiQ3U3C9
PeptideAtlasiQ3U3C9
PRIDEiQ3U3C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034279; ENSMUSP00000034279; ENSMUSG00000031822 [Q3U3C9-2]
ENSMUST00000118136; ENSMUSP00000112981; ENSMUSG00000031822 [Q3U3C9-1]
ENSMUST00000120493; ENSMUSP00000113577; ENSMUSG00000031822 [Q3U3C9-3]
GeneIDi382034
KEGGimmu:382034
UCSCiuc009nqz.2 mouse [Q3U3C9-2]
uc009nra.2 mouse [Q3U3C9-1]
uc009nrc.2 mouse [Q3U3C9-4]

Organism-specific databases

CTDi23199
MGIiMGI:1098275 Gse1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGKK Eukaryota
ENOG410Z7HR LUCA
GeneTreeiENSGT00700000104539
HOGENOMiHOG000112825
HOVERGENiHBG079773
InParanoidiQ3U3C9
OMAiKPWEPFM
OrthoDBiEOG091G031Y
PhylomeDBiQ3U3C9
TreeFamiTF332496

Miscellaneous databases

ChiTaRSiGse1 mouse
PROiPR:Q3U3C9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031822 Expressed in 236 organ(s), highest expression level in thymus
CleanExiMM_GSE1
ExpressionAtlasiQ3U3C9 baseline and differential
GenevisibleiQ3U3C9 MM

Family and domain databases

InterProiView protein in InterPro
IPR022207 GSE-like
PfamiView protein in Pfam
PF12540 DUF3736, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGSE1_MOUSE
AccessioniPrimary (citable) accession number: Q3U3C9
Secondary accession number(s): Q3UWZ5
, Q80U67, Q80XR0, Q8CCF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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