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Entry version 79 (26 Feb 2020)
Sequence version 1 (11 Oct 2005)
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Protein

PH domain-containing protein

Gene

Triobp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TriobpImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349410 Triobp

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q3U2M9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini832 – 928PHInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 663DisorderedSequence analysisAdd BLAST663
Regioni701 – 781DisorderedSequence analysisAdd BLAST81
Regioni795 – 828DisorderedSequence analysisAdd BLAST34
Regioni931 – 1063DisorderedSequence analysisAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1108 – 1128Sequence analysisAdd BLAST21
Coiled coili1166 – 1193Sequence analysisAdd BLAST28
Coiled coili1231 – 1258Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 100PolarSequence analysisAdd BLAST79
Compositional biasi362 – 376PolyampholyteSequence analysisAdd BLAST15
Compositional biasi403 – 426PolyampholyteSequence analysisAdd BLAST24
Compositional biasi431 – 474PolarSequence analysisAdd BLAST44
Compositional biasi475 – 489PolyampholyteSequence analysisAdd BLAST15
Compositional biasi504 – 518PolyampholyteSequence analysisAdd BLAST15
Compositional biasi522 – 545PolarSequence analysisAdd BLAST24
Compositional biasi611 – 627PolarSequence analysisAdd BLAST17
Compositional biasi717 – 740PolarSequence analysisAdd BLAST24
Compositional biasi747 – 781PolarSequence analysisAdd BLAST35
Compositional biasi795 – 824PolyampholyteSequence analysisAdd BLAST30
Compositional biasi932 – 962PolarSequence analysisAdd BLAST31
Compositional biasi1006 – 1036PolyampholyteSequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4807 Eukaryota
ENOG410ZA8F LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13275 PH_M-RIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q3U2M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GNSRNPSPHR TNKDIPWASF PLRPTQSDSP RTSSPSRTKQ NQVPWASISL
60 70 80 90 100
RPTQGDKPQT SAPTRLAHND PPQQYSPSLA TTSSSSHNPG HSSASRTSSP
110 120 130 140 150
LHAAPRGAPQ TSLESSQPPC TVCIGHRDAP RASSPPRYFQ YDPFPFFPDP
160 170 180 190 200
RSSESESPHH EPPYMPPAVC IGHRDAPRAT SPPRHTQFDP FPFLPDTSDA
210 220 230 240 250
DNESPQHDPP QFPPPVCIGY RDAPRASSPP RQFPEPSFFQ DLPRASTESL
260 270 280 290 300
VPSTDSMHEP PHIPTPVCIG HRDAPSFSSP PRQAPEPSLF FQDPPGTSME
310 320 330 340 350
SLAPSIDSLH GCPLLPPQVC IGHRDAPRAS SPPRHPPSDI GLLAPSPPPG
360 370 380 390 400
SSGSRGSAPP GETRHNLERE EYTMLADLPP PRRLAQRGPE PQAQGSNEGR
410 420 430 440 450
TRSPGRAEVE RLFGQERRKS EAPGAFQTRD EGRSQRPSQA QSQLRRQSSP
460 470 480 490 500
APSRQVTKPS AKQAEPTRQS RTGSPHPKSP DKRPEGDRQL QRTSPPARTP
510 520 530 540 550
ARPPERKAQI ERHLESGHTG PRQSLGGWQS QERLSGPQSP NRHPEKSWGS
560 570 580 590 600
QKEGPSLGGW PELEGPSLEG IWRGPPQEHR EQWGHSEAWE EPPSNGIQGA
610 620 630 640 650
PPRGQGRLQE LSRPHQPTPS SENSWAGPAE CSCALQPEAS TAVGWRAEGT
660 670 680 690 700
SPHQRSAERP PDLDWRDLLG LLRAPEDGAW TRLPRLDWEG LLELLQARLP
710 720 730 740 750
QKDPARHWHD PAKASGPEQG SSGTEDTLKT EPQTQPEGRA KATLANGHRP
760 770 780 790 800
GQQSESPAQL PSPACTSTQW PTTKVTSGPE TSPLAALEQI DHLESHSPPD
810 820 830 840 850
LEFQPEEPEA SEPSRGEDSR AVQKQADSPD LLNFKKGWMS ILDEPGEWKK
860 870 880 890 900
HWFVLADSSL KYYRDSTAEE ADELDGEIDL RSCTDVTEYA VQRNYGFQIH
910 920 930 940 950
TKDAVYTLSA MTSGIRRNWI EALRKTVRPT SAPDVTKLSD CNKENTLHGY
960 970 980 990 1000
GTQKSSLKIG EQRTGSEVIG RGGPRKADGP RPSLDYVELS PLAPSSPQRM
1010 1020 1030 1040 1050
RTLSRSTPER PTKQEDLERD LAQRSEERRK WFESTDGRTP ETPSGDGSRR
1060 1070 1080 1090 1100
GLGAPLTDDQ QSRLSEEIEK KWQELEKLPL RENKRVPLTA LLNQAHNDRR
1110 1120 1130 1140 1150
RGPTSDSHEA LEKEVQSLRA QLEAWRLRGE APQNAPRLQE DSHIPPGYIS
1160 1170 1180 1190 1200
QEACERSLAE MESPHQQVME QLQRHHEREL QRLQQEKEWL LAEETAATAS
1210 1220 1230 1240 1250
AIEAMKKAYQ EELSRELSKT RSLQQGPESL RKQHQLDMEA LKQELQVLSE
1260 1270 1280 1290 1300
RYSQKCLEIG ALTRQAEERE HTLRRCQQEG QKLLRHNQEL HSHLSEEIDR
1310 1320 1330
LRSFIASQGT GNSCGRSNER SSCELEVLLR
Length:1,330
Mass (Da):147,953
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDE140AD9EC50739
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1330Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK155197 mRNA Translation: BAE33111.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155197 mRNA Translation: BAE33111.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ3U2M9

Organism-specific databases

MGIiMGI:1349410 Triobp

Phylogenomic databases

eggNOGiKOG4807 Eukaryota
ENOG410ZA8F LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Triobp mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd13275 PH_M-RIP, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039597 M-RIP_PH
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3U2M9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U2M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 26, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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