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UniProtKB - Q3U288 (ZN710_MOUSE)
Protein
Zinc finger protein 710
Gene
Znf710
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 297 – 319 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 325 – 347 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 403 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 577 – 600 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 710 |
Gene namesi | Name:Znf710 Synonyms:Zfp710 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921747, Zfp710 |
VEuPathDBi | HostDB:ENSMUSG00000048897 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233709 | 1 – 666 | Zinc finger protein 710Add BLAST | 666 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 113 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 379 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q3U288 |
PaxDbi | Q3U288 |
PeptideAtlasi | Q3U288 |
PRIDEi | Q3U288 |
ProteomicsDBi | 275032 [Q3U288-1] 275033 [Q3U288-2] 275034 [Q3U288-3] |
PTM databases
iPTMneti | Q3U288 |
PhosphoSitePlusi | Q3U288 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048897, Expressed in skeletal muscle tissue and 227 other tissues |
Genevisiblei | Q3U288, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229060, 33 interactors |
STRINGi | 10090.ENSMUSP00000050577 |
Miscellaneous databases
RNActi | Q3U288, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 113 – 141 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 297 – 319 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 325 – 347 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 403 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 577 – 600 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155498 |
HOGENOMi | CLU_002678_54_1_1 |
InParanoidi | Q3U288 |
OMAi | MEDYEEN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3U288 |
TreeFami | TF331510 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3U288-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGFMDSGTQ TDAVVVLSLA QAAVLGLVSE NELFGATISA EAFYPDLGPE
60 70 80 90 100
LTGTAMGEPG PPGPDIYQLA CNGRALEEPP EEEVLEVEAA FEKHTRRKTR
110 120 130 140 150
PPVRLVPKVK FEKAEEEEEQ EVYEVSVPGD DKDPGPAEAP AEVASSGCEA
160 170 180 190 200
LVQSSAVKMI DLSAFSRKPR TLRHLPRTPR PELDMAPFDP PFPDPARDGF
210 220 230 240 250
PEPSMALPGP ETLPTECSFE PPHLAPLSNP EPPNMTSTTE LVKPEQGFVW
260 270 280 290 300
QESSEFEADT AGSTVERHKK AQLDRLDINV QIDDSYLVEA GDRQKRWQCR
310 320 330 340 350
MCEKSYTSKY NLVTHILGHN GIKPHSCPHC SKLFKQPSHL QTHLLTHQGT
360 370 380 390 400
RPHKCQVCHK AFTQTSHLKR HMLLHSEVKP YSCHFCGRGF AYPSELKAHE
410 420 430 440 450
VKHESGRCHV CVECGLDFST LTQLKRHLAS HQGPTLYQCL ECDKSFHYRS
460 470 480 490 500
QLQNHMLKHQ NVRPFVCTEC GMEFSQIHHL KQHSLTHKGV KEFKCEVCGR
510 520 530 540 550
EFTLQANMKR HMLIHTSVRP YQCHICFKTF VQKQTLKTHM IVHSPVKPFK
560 570 580 590 600
CKVCGKSFNR MYNLLGHMHL HAGSKPFKCP YCSSKFNLKG NLSRHMKVKH
610 620 630 640 650
GVMDISLDSQ DPMMELAGPD PSELDNHQEM EDFEENAYTY SSVDSSAEAS
660
TLTEQAMKEM AYYNVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RP56 | A0A0U1RP56_MOUSE | Zinc finger protein 710 | Zfp710 | 31 | Annotation score: |
Sequence cautioni
The sequence AAH58640 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH60641 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC40892 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | M → L in BAE32948 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 259 | D → E in BAE32948 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 409 | H → R in BAC39083 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 620 | D → G in BAE32948 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018152 | 611 – 666 | DPMME…YYNVL → GGWAVRSGQSRIDSSMAHSG VSSPIRGVGGLAKAETSMRW AQVWREGEPGEPLWQ in isoform 2. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_026943 | 611 – 666 | DPMME…YYNVL → GMLSTAARAAGCSYASSSST QSAILCGVQGQPETP in isoform 3. 1 PublicationAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036711 mRNA Translation: BAC29546.1 AK083979 mRNA Translation: BAC39083.1 AK089457 mRNA Translation: BAC40892.1 Different initiation. AK154871 mRNA Translation: BAE32892.1 AK154953 mRNA Translation: BAE32948.1 AK155416 mRNA Translation: BAE33254.1 BC058640 mRNA Translation: AAH58640.3 Different initiation. BC060641 mRNA Translation: AAH60641.1 Different initiation. |
CCDSi | CCDS52279.1 [Q3U288-3] CCDS52280.1 [Q3U288-1] |
RefSeqi | NP_001139471.1, NM_001145999.1 [Q3U288-1] NP_001139472.1, NM_001146000.1 [Q3U288-3] NP_780642.3, NM_175433.5 [Q3U288-1] XP_006540805.1, XM_006540742.3 [Q3U288-1] XP_006540806.1, XM_006540743.3 [Q3U288-1] XP_006540807.1, XM_006540744.3 [Q3U288-1] |
Genome annotation databases
Ensembli | ENSMUST00000049680; ENSMUSP00000050577; ENSMUSG00000048897 [Q3U288-1] ENSMUST00000164056; ENSMUSP00000132361; ENSMUSG00000048897 [Q3U288-1] ENSMUST00000166250; ENSMUSP00000129357; ENSMUSG00000048897 [Q3U288-3] ENSMUST00000206039; ENSMUSP00000146148; ENSMUSG00000048897 [Q3U288-2] |
GeneIDi | 209225 |
KEGGi | mmu:209225 |
UCSCi | uc009hzi.2, mouse [Q3U288-3] uc009hzj.2, mouse [Q3U288-1] uc009hzk.2, mouse [Q3U288-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036711 mRNA Translation: BAC29546.1 AK083979 mRNA Translation: BAC39083.1 AK089457 mRNA Translation: BAC40892.1 Different initiation. AK154871 mRNA Translation: BAE32892.1 AK154953 mRNA Translation: BAE32948.1 AK155416 mRNA Translation: BAE33254.1 BC058640 mRNA Translation: AAH58640.3 Different initiation. BC060641 mRNA Translation: AAH60641.1 Different initiation. |
CCDSi | CCDS52279.1 [Q3U288-3] CCDS52280.1 [Q3U288-1] |
RefSeqi | NP_001139471.1, NM_001145999.1 [Q3U288-1] NP_001139472.1, NM_001146000.1 [Q3U288-3] NP_780642.3, NM_175433.5 [Q3U288-1] XP_006540805.1, XM_006540742.3 [Q3U288-1] XP_006540806.1, XM_006540743.3 [Q3U288-1] XP_006540807.1, XM_006540744.3 [Q3U288-1] |
3D structure databases
SMRi | Q3U288 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229060, 33 interactors |
STRINGi | 10090.ENSMUSP00000050577 |
PTM databases
iPTMneti | Q3U288 |
PhosphoSitePlusi | Q3U288 |
Proteomic databases
MaxQBi | Q3U288 |
PaxDbi | Q3U288 |
PeptideAtlasi | Q3U288 |
PRIDEi | Q3U288 |
ProteomicsDBi | 275032 [Q3U288-1] 275033 [Q3U288-2] 275034 [Q3U288-3] |
Protocols and materials databases
DNASUi | 209225 |
Genome annotation databases
Ensembli | ENSMUST00000049680; ENSMUSP00000050577; ENSMUSG00000048897 [Q3U288-1] ENSMUST00000164056; ENSMUSP00000132361; ENSMUSG00000048897 [Q3U288-1] ENSMUST00000166250; ENSMUSP00000129357; ENSMUSG00000048897 [Q3U288-3] ENSMUST00000206039; ENSMUSP00000146148; ENSMUSG00000048897 [Q3U288-2] |
GeneIDi | 209225 |
KEGGi | mmu:209225 |
UCSCi | uc009hzi.2, mouse [Q3U288-3] uc009hzj.2, mouse [Q3U288-1] uc009hzk.2, mouse [Q3U288-2] |
Organism-specific databases
CTDi | 209225 |
MGIi | MGI:1921747, Zfp710 |
VEuPathDBi | HostDB:ENSMUSG00000048897 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155498 |
HOGENOMi | CLU_002678_54_1_1 |
InParanoidi | Q3U288 |
OMAi | MEDYEEN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3U288 |
TreeFami | TF331510 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 209225, 5 hits in 67 CRISPR screens |
ChiTaRSi | Zfp710, mouse |
PROi | PR:Q3U288 |
RNActi | Q3U288, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048897, Expressed in skeletal muscle tissue and 227 other tissues |
Genevisiblei | Q3U288, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN710_MOUSE | |
Accessioni | Q3U288Primary (citable) accession number: Q3U288 Secondary accession number(s): Q3U341 Q8BZ48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families