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Protein

Protein SERAC1

Gene

Serac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Protein family/group databases

ESTHERimouse-srac1 PGAP1

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SERAC1
Alternative name(s):
Serine active site-containing protein 1
Gene namesi
Name:Serac1
Synonyms:D17Ertd141e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2447813 Serac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 54HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746731 – 654Protein SERAC1Add BLAST654

Proteomic databases

MaxQBiQ3U213
PaxDbiQ3U213
PeptideAtlasiQ3U213
PRIDEiQ3U213

PTM databases

PhosphoSitePlusiQ3U213

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000015659 Expressed in 265 organ(s), highest expression level in secondary oocyte
CleanExiMM_SERAC1
GenevisibleiQ3U213 MM

Interactioni

Protein-protein interaction databases

BioGridi236459, 1 interactor
STRINGi10090.ENSMUSP00000095043

Structurei

3D structure databases

ProteinModelPortaliQ3U213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi107 – 110Poly-Ala4
Compositional biasi194 – 199Poly-Pro6

Sequence similaritiesi

Belongs to the SERAC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2029 Eukaryota
ENOG410YIPC LUCA
GeneTreeiENSGT00390000003560
HOGENOMiHOG000154411
HOVERGENiHBG057428
InParanoidiQ3U213
OMAiKTMANLD
OrthoDBiEOG091G061M
PhylomeDBiQ3U213
TreeFamiTF319689

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
SSF53474 SSF53474, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3U213-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLAAYCVIC CRRIGSFAPR SKSRTPWRNI RNIIRFTGSL IVGGSLFITY
60 70 80 90 100
EVLALKKSLM LDTQVVEREK MKSYIYVHKA PVDRLDNRGI VWQARKELHR
110 120 130 140 150
AVRKLLAAAA KVLRSPFADS FSTVDIEDHD CAVWLLLRKS REDDLAARLQ
160 170 180 190 200
AVREMSEAHH WHDYQYRIIA QACDPRTLIG LARSKESDLR FFLPPPPLPS
210 220 230 240 250
LKEDSSTEEE LRHLLASLPQ TELDECLQYF TSLALSESSQ SLAAQKGGLW
260 270 280 290 300
CFGGNGLPYA ESFGKVPSAT VEMFCLEAIV KHSEIPSHCD HIEAGGGLQL
310 320 330 340 350
LQRLYQLHKD CPKVQRNVMR IIGNMALNEH LHPAIVHSGW VSLMAEALKS
360 370 380 390 400
SHIMEASHAA RTLANLDRET VGEKYQDGVY VLHPQCRTSQ PIKADVLFIH
410 420 430 440 450
GLMGAAFKTW RQHDSQRALT ESAVVDEDRY TTCWPKTWLA KDCPSLRIIS
460 470 480 490 500
VEYDTSLSDW RARCPMERKS IAFRSNELLS KLRAAGVGDR PMIWISHSMG
510 520 530 540 550
GLLVKKMLLE ASKKPELNAL INNTRGIIFY SVPHHGSRLA EYSVNIRYLL
560 570 580 590 600
FPSLEVKELS KDSPALKTLQ DDFLEFAKDK NFQVLNFVET QPTFIGSMIK
610 620 630 640 650
LHVVPVESAD LGIGDLIPVD VNHLNICKPK TKDAFLYQRT LQFICETLAR

DLEN
Length:654
Mass (Da):73,987
Last modified:October 11, 2005 - v1
Checksum:iD75EE0017C3B579F
GO
Isoform 2 (identifier: Q3U213-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-118: Missing.

Show »
Length:624
Mass (Da):70,648
Checksum:iDAD7409643A26AF4
GO
Isoform 3 (identifier: Q3U213-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-342: VS → DR
     343-654: Missing.

Show »
Length:342
Mass (Da):38,729
Checksum:iA095E0D0161A451D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti4A → V in strain: C57BL/6J. 2 Publications1
Natural varianti6Y → F in strain: C57BL/6J. 2 Publications1
Natural varianti7C → F in strain: C57BL/6J. 2 Publications1
Natural varianti25T → M1 Publication1
Natural varianti64Q → T in strain: BALB/cByJ and C57BL/6J; requires 2 nucleotide substitutions. 2 Publications1
Natural varianti518N → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02286489 – 118Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_022865341 – 342VS → DR in isoform 3. 1 Publication2
Alternative sequenceiVSP_022866343 – 654Missing in isoform 3. 1 PublicationAdd BLAST312

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019677 mRNA Translation: BAB31833.1
AK154605 mRNA Translation: BAE32707.1
AK155571 mRNA Translation: BAE33329.1
AK162246 mRNA Translation: BAE36813.1
AK170498 mRNA Translation: BAE41837.1
BC119594 mRNA Translation: AAI19595.1
BC119595 mRNA Translation: AAI19596.1
CCDSiCCDS28366.1 [Q3U213-2]
CCDS49933.1 [Q3U213-1]
RefSeqiNP_001104487.1, NM_001111017.1 [Q3U213-1]
NP_796285.2, NM_177311.4 [Q3U213-2]
UniGeneiMm.5548

Genome annotation databases

EnsembliENSMUST00000024570; ENSMUSP00000024570; ENSMUSG00000015659 [Q3U213-2]
ENSMUST00000097432; ENSMUSP00000095043; ENSMUSG00000015659 [Q3U213-1]
GeneIDi321007
KEGGimmu:321007
UCSCiuc008afy.2 mouse [Q3U213-2]
uc008afz.2 mouse [Q3U213-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019677 mRNA Translation: BAB31833.1
AK154605 mRNA Translation: BAE32707.1
AK155571 mRNA Translation: BAE33329.1
AK162246 mRNA Translation: BAE36813.1
AK170498 mRNA Translation: BAE41837.1
BC119594 mRNA Translation: AAI19595.1
BC119595 mRNA Translation: AAI19596.1
CCDSiCCDS28366.1 [Q3U213-2]
CCDS49933.1 [Q3U213-1]
RefSeqiNP_001104487.1, NM_001111017.1 [Q3U213-1]
NP_796285.2, NM_177311.4 [Q3U213-2]
UniGeneiMm.5548

3D structure databases

ProteinModelPortaliQ3U213
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236459, 1 interactor
STRINGi10090.ENSMUSP00000095043

Protein family/group databases

ESTHERimouse-srac1 PGAP1

PTM databases

PhosphoSitePlusiQ3U213

Proteomic databases

MaxQBiQ3U213
PaxDbiQ3U213
PeptideAtlasiQ3U213
PRIDEiQ3U213

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024570; ENSMUSP00000024570; ENSMUSG00000015659 [Q3U213-2]
ENSMUST00000097432; ENSMUSP00000095043; ENSMUSG00000015659 [Q3U213-1]
GeneIDi321007
KEGGimmu:321007
UCSCiuc008afy.2 mouse [Q3U213-2]
uc008afz.2 mouse [Q3U213-1]

Organism-specific databases

CTDi84947
MGIiMGI:2447813 Serac1

Phylogenomic databases

eggNOGiKOG2029 Eukaryota
ENOG410YIPC LUCA
GeneTreeiENSGT00390000003560
HOGENOMiHOG000154411
HOVERGENiHBG057428
InParanoidiQ3U213
OMAiKTMANLD
OrthoDBiEOG091G061M
PhylomeDBiQ3U213
TreeFamiTF319689

Miscellaneous databases

PROiPR:Q3U213
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015659 Expressed in 265 organ(s), highest expression level in secondary oocyte
CleanExiMM_SERAC1
GenevisibleiQ3U213 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
SSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRAC1_MOUSE
AccessioniPrimary (citable) accession number: Q3U213
Secondary accession number(s): Q3TS62, Q9D2G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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