UniProtKB - Q3U1Z6 (Q3U1Z6_MOUSE)
Protein
Interleukin
Gene
Il15
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- cytokine receptor binding Source: InterPro
GO - Biological processi
- aging Source: Ensembl
- cellular response to vitamin D Source: Ensembl
- hyaluronan metabolic process Source: Ensembl
- immune response Source: InterPro
- inflammatory response Source: Ensembl
- interleukin-15-mediated signaling pathway Source: Ensembl
- macrophage differentiation Source: Ensembl
- negative regulation of smooth muscle cell proliferation Source: Ensembl
- neutrophil activation Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of interleukin-17 production Source: Ensembl
- positive regulation of phagocytosis Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- skeletal muscle atrophy Source: Ensembl
- tyrosine phosphorylation of STAT protein Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: InterleukinUniRule annotation |
Gene namesi | Name:Il15Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:103014, Il15 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nuclear speck Source: Ensembl
Other locations
- cell surface Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031712, Expressed in granulocyte and 169 other tissues |
ExpressionAtlasi | Q3U1Z6, baseline and differential |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- cytokine receptor binding Source: InterPro
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_135111_0_0_1 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U1Z6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKILKPYMRN TSISCYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW
60 70 80 90 100
IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH
110 120 130 140 150
EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS
160
FIRIVQMFIN TS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK155616 mRNA Translation: BAE33347.1 |
RefSeqi | NP_001241676.1, NM_001254747.1 NP_032383.1, NM_008357.2 XP_006530768.1, XM_006530705.3 XP_006530769.1, XM_006530706.3 XP_006530770.1, XM_006530707.3 XP_006530771.1, XM_006530708.3 XP_006530772.1, XM_006530709.2 XP_006530773.1, XM_006530710.2 XP_006530774.1, XM_006530711.3 XP_006530775.1, XM_006530712.3 XP_006530776.1, XM_006530713.3 XP_011246614.1, XM_011248312.2 XP_011246615.1, XM_011248313.2 XP_011246616.1, XM_011248314.2 |
Genome annotation databases
GeneIDi | 16168 |
KEGGi | mmu:16168 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK155616 mRNA Translation: BAE33347.1 |
RefSeqi | NP_001241676.1, NM_001254747.1 NP_032383.1, NM_008357.2 XP_006530768.1, XM_006530705.3 XP_006530769.1, XM_006530706.3 XP_006530770.1, XM_006530707.3 XP_006530771.1, XM_006530708.3 XP_006530772.1, XM_006530709.2 XP_006530773.1, XM_006530710.2 XP_006530774.1, XM_006530711.3 XP_006530775.1, XM_006530712.3 XP_006530776.1, XM_006530713.3 XP_011246614.1, XM_011248312.2 XP_011246615.1, XM_011248313.2 XP_011246616.1, XM_011248314.2 |
3D structure databases
SMRi | Q3U1Z6 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 3844, 1083 antibodies |
Genome annotation databases
GeneIDi | 16168 |
KEGGi | mmu:16168 |
Organism-specific databases
CTDi | 3600 |
MGIi | MGI:103014, Il15 |
Phylogenomic databases
HOGENOMi | CLU_135111_0_0_1 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16168, 0 hits in 18 CRISPR screens |
ChiTaRSi | Il15, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031712, Expressed in granulocyte and 169 other tissues |
ExpressionAtlasi | Q3U1Z6, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR038327, IL-15/IL-21_sf IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U1Z6_MOUSE | |
Accessioni | Q3U1Z6Primary (citable) accession number: Q3U1Z6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |