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Protein

Ubiquitin-conjugating enzyme E2 variant 3

Gene

Uevld

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible negative regulator of polyubiquitination.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 219NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 3
Short name:
UEV-3
Alternative name(s):
EV and lactate/malate dehydrogenase domain-containing protein
Gene namesi
Name:Uevld
Synonyms:Attp, Uev3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1860490 Uevld

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786521 – 471Ubiquitin-conjugating enzyme E2 variant 3Add BLAST471

Proteomic databases

EPDiQ3U1V6
MaxQBiQ3U1V6
PaxDbiQ3U1V6
PeptideAtlasiQ3U1V6
PRIDEiQ3U1V6

PTM databases

iPTMnetiQ3U1V6
PhosphoSitePlusiQ3U1V6

Expressioni

Gene expression databases

BgeeiENSMUSG00000043262 Expressed in 210 organ(s), highest expression level in cochlea
CleanExiMM_UEVLD
ExpressionAtlasiQ3U1V6 baseline and differential
GenevisibleiQ3U1V6 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091964

Structurei

3D structure databases

ProteinModelPortaliQ3U1V6
SMRiQ3U1V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145UEVPROSITE-ProRule annotationAdd BLAST144

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 215Poly-Leu6

Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.Curated
In the C-terminal section; belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
KOG2391 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ3U1V6
OMAiKGGTMDL
OrthoDBiEOG091G0HRA
PhylomeDBiQ3U1V6
TreeFamiTF314963

Family and domain databases

Gene3Di3.10.110.10, 1 hit
3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PF05743 UEV, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54495 SSF54495, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS51322 UEV, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U1V6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFDCEGVRR LLGKYKFRDL TVEELKNVSV SFPHFRYSVD TYVFKDTSQK
60 70 80 90 100
DLLNFTGTIP VMYQGKTYNI PIRFWILDSH PFAPPICFLK PTANMEISVG
110 120 130 140 150
KHVDAKGRIY LPYLQNWSHP KSAIVGLIKE MIAKFQEELP LYSIPSSNEA
160 170 180 190 200
QQVDLLAYIT KITEGVSDIN SRGWTNHENK ILNKITVVGS GDLGIACTLA
210 220 230 240 250
ISAKGIADKL LLLDLSDGMS QGTMDLDIFN LPNVEISKDL SASAHSKVVI
260 270 280 290 300
FTANSLGGSE SYLHAVQSNV DMFRALVPAL GHYSQHAVLL VASQPVEIMS
310 320 330 340 350
YVTWKLSTFP ATRVVGIGCN LDSQRLQYII TSVLKVQTSG KEVWVVGEQG
360 370 380 390 400
ENKVCSWSGR DGVLSPSSQA QLSSRAMELL KVKGQRSWSV GLSVADLVDT
410 420 430 440 450
IINNKRKVHS VSTLAKGYYG LDNEVFLSLP CILGTGGVSE VIKTKAGEDT
460 470
VTGTLQASAS SIHALQQQLE L
Length:471
Mass (Da):51,681
Last modified:October 11, 2005 - v1
Checksum:i650A5B9F0B5E5146
GO
Isoform 2 (identifier: Q3U1V6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-250: DLSASAHSKVVI → GGDLHSQLFGRF
     251-471: Missing.

Show »
Length:250
Mass (Da):28,081
Checksum:i1A3B6FB1525DB0BA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSG9A0A1B0GSG9_MOUSE
Ubiquitin-conjugating enzyme E2 var...
Uevld
73Annotation score:
A0A140LHE8A0A140LHE8_MOUSE
Ubiquitin-conjugating enzyme E2 var...
Uevld
46Annotation score:

Sequence cautioni

The sequence AAB57699 differs from that shown. Reason: Frameshift at position 146.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26Missing in AAH54796 (PubMed:15489334).Curated1
Sequence conflicti134K → R in AAB57699 (Ref. 3) Curated1
Sequence conflicti166 – 169VSDI → LYCQ in AAB57699 (Ref. 3) Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023352239 – 250DLSAS…SKVVI → GGDLHSQLFGRF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_023353251 – 471Missing in isoform 2. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154536 mRNA Translation: BAE32661.1
AK155685 mRNA Translation: BAE33387.1
BC054796 mRNA Translation: AAH54796.1
U97571 mRNA Translation: AAB57699.1 Frameshift.
CCDSiCCDS39965.1 [Q3U1V6-1]
RefSeqiNP_001035785.1, NM_001040695.1 [Q3U1V6-1]
UniGeneiMm.1999

Genome annotation databases

EnsembliENSMUST00000094398; ENSMUSP00000091964; ENSMUSG00000043262 [Q3U1V6-1]
ENSMUST00000207986; ENSMUSP00000146930; ENSMUSG00000043262 [Q3U1V6-2]
GeneIDi54122
KEGGimmu:54122
UCSCiuc009gzr.1 mouse [Q3U1V6-1]
uc009gzs.1 mouse [Q3U1V6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154536 mRNA Translation: BAE32661.1
AK155685 mRNA Translation: BAE33387.1
BC054796 mRNA Translation: AAH54796.1
U97571 mRNA Translation: AAB57699.1 Frameshift.
CCDSiCCDS39965.1 [Q3U1V6-1]
RefSeqiNP_001035785.1, NM_001040695.1 [Q3U1V6-1]
UniGeneiMm.1999

3D structure databases

ProteinModelPortaliQ3U1V6
SMRiQ3U1V6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091964

PTM databases

iPTMnetiQ3U1V6
PhosphoSitePlusiQ3U1V6

Proteomic databases

EPDiQ3U1V6
MaxQBiQ3U1V6
PaxDbiQ3U1V6
PeptideAtlasiQ3U1V6
PRIDEiQ3U1V6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094398; ENSMUSP00000091964; ENSMUSG00000043262 [Q3U1V6-1]
ENSMUST00000207986; ENSMUSP00000146930; ENSMUSG00000043262 [Q3U1V6-2]
GeneIDi54122
KEGGimmu:54122
UCSCiuc009gzr.1 mouse [Q3U1V6-1]
uc009gzs.1 mouse [Q3U1V6-2]

Organism-specific databases

CTDi55293
MGIiMGI:1860490 Uevld

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
KOG2391 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ3U1V6
OMAiKGGTMDL
OrthoDBiEOG091G0HRA
PhylomeDBiQ3U1V6
TreeFamiTF314963

Miscellaneous databases

PROiPR:Q3U1V6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043262 Expressed in 210 organ(s), highest expression level in cochlea
CleanExiMM_UEVLD
ExpressionAtlasiQ3U1V6 baseline and differential
GenevisibleiQ3U1V6 MM

Family and domain databases

Gene3Di3.10.110.10, 1 hit
3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PF05743 UEV, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54495 SSF54495, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS51322 UEV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUEVLD_MOUSE
AccessioniPrimary (citable) accession number: Q3U1V6
Secondary accession number(s): O08761, Q7TQD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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