UniProtKB - Q3U1U7 (AHRR_MOUSE)
Aryl hydrocarbon receptor repressor
Ahrr
Functioni
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
2 PublicationsGO - Molecular functioni
- nuclear receptor activity Source: GO_Central
- protein dimerization activity Source: InterPro
- transcription cis-regulatory region binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of protein sumoylation Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to xenobiotic stimulus Source: BHF-UCL
- xenobiotic metabolic process Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-211945, Phase I - Functionalization of compounds R-MMU-211976, Endogenous sterols R-MMU-211981, Xenobiotics R-MMU-8937144, Aryl hydrocarbon receptor signalling |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor repressorShort name: AhR repressor Short name: AhRR |
Gene namesi | Name:Ahrr Synonyms:Kiaa1234 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333776, Ahrr |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: BHF-UCL
Other locations
- aryl hydrocarbon receptor complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333858 | 1 – 701 | Aryl hydrocarbon receptor repressorAdd BLAST | 701 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 583 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 660 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q3U1U7 |
PaxDbi | Q3U1U7 |
PRIDEi | Q3U1U7 |
ProteomicsDBi | 281958 [Q3U1U7-1] 281959 [Q3U1U7-2] 281960 [Q3U1U7-3] |
PTM databases
iPTMneti | Q3U1U7 |
PhosphoSitePlusi | Q3U1U7 |
Expressioni
Inductioni
Interactioni
Subunit structurei
Interacts with ARNT, ANKRA2, HDAC4 and HDAC5.
Interacts with ARNT; forms a heterodimer with ARNT (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 198038, 4 interactors |
CORUMi | Q3U1U7 |
STRINGi | 10090.ENSMUSP00000022059 |
Miscellaneous databases
RNActi | Q3U1U7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 78 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 106 – 176 | PASPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 409 – 432 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 555 – 701 | Needed for transcriptional repressionAdd BLAST | 147 |
Phylogenomic databases
eggNOGi | KOG3560, Eukaryota |
InParanoidi | Q3U1U7 |
OrthoDBi | 325707at2759 |
PhylomeDBi | Q3U1U7 |
TreeFami | TF352074 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR039091, AHR/AHRR IPR039092, AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF3, PTHR10649:SF3, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMIPSGECTY AGRKRRKPIQ KRRLTMGAEK SNPSKRHRDR LNTELDHLAS
60 70 80 90 100
LLPFSPDIIS KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEEH
110 120 130 140 150
SYRGFPVQEG RLLLESLNGF ALVVSAEGMI FYASATIVDY LGFHQTDVMH
160 170 180 190 200
QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF GQSPHADTDN TVLGKLLRAQ
210 220 230 240 250
EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK LKFLFGQKKK
260 270 280 290 300
TPSGTALPPR LSLFCIVAPV LPSVTEMKMK STFLKAKHRA DIVVTMDSRA
310 320 330 340 350
KAVTSLCESE LHPKLNYLAG KSNGENGISL FRGQTDRSHW ARALARSSCL
360 370 380 390 400
CLRGGPDLLD PKGTSGDREE EDQKHILRRS PGAWGQREMH KYSYGLETPV
410 420 430 440 450
HLRHLNWSTE QRSQESTTKL TRQPSKNEPS TCLVPHGSCV PYPGSQGMLS
460 470 480 490 500
ASNMASFRDS LDHPTGAYCS QMNRPLSDIH QGQVDPSTCH ISQGSLGSRI
510 520 530 540 550
PLTGMQRFTA RGFSTEDAKL PSLPVTIGTP CNPVLSLDVP IKMENESGSQ
560 570 580 590 600
DIVEASTTSC LWLGTSDMAR GHLVGFPARM HLKTEPDYRQ QACTPHLGHG
610 620 630 640 650
MLGTNPYSRD TVGSCREHAP LYSAHCTCLD PEPPHHLFMC SHSESQHPSL
660 670 680 690 700
DQDCRAPIVK REPLDSPSWA APGQVTVPRM FPKSASKTVI PSKGSDGIFL
P
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J020 | A0A0R4J020_MOUSE | Aryl hydrocarbon receptor repressor | Ahrr | 701 | Annotation score: | ||
A0A0R4J1D3 | A0A0R4J1D3_MOUSE | Aryl hydrocarbon receptor repressor | Ahrr | 573 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | I → V in BAE32810 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 637 | L → F in BAA37132 (PubMed:9887096).Curated | 1 | |
Sequence conflicti | 637 | L → F in BAE32410 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 637 | L → F in BAE32810 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 637 | L → F in AAI18535 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033565 | 1 – 128 | Missing in isoform 2. 1 PublicationAdd BLAST | 128 | |
Alternative sequenceiVSP_033566 | 300 – 701 | Missing in isoform 3. 1 PublicationAdd BLAST | 402 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015140 mRNA Translation: BAA37132.1 AK154152 mRNA Translation: BAE32410.1 AK154761 mRNA Translation: BAE32810.1 AK155711 mRNA Translation: BAE33396.1 AC123833 Genomic DNA No translation available. CT009486 Genomic DNA No translation available. BC118534 mRNA Translation: AAI18535.1 AK173134 mRNA Translation: BAD32412.1 |
CCDSi | CCDS26641.1 [Q3U1U7-1] CCDS84037.1 [Q3U1U7-2] |
RefSeqi | NP_001304280.1, NM_001317351.1 NP_033774.1, NM_009644.3 XP_006517111.1, XM_006517048.1 XP_006517112.1, XM_006517049.3 XP_006517113.1, XM_006517050.2 |
Genome annotation databases
GeneIDi | 11624 |
KEGGi | mmu:11624 |
UCSCi | uc007rev.1, mouse [Q3U1U7-1] uc007rex.1, mouse [Q3U1U7-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015140 mRNA Translation: BAA37132.1 AK154152 mRNA Translation: BAE32410.1 AK154761 mRNA Translation: BAE32810.1 AK155711 mRNA Translation: BAE33396.1 AC123833 Genomic DNA No translation available. CT009486 Genomic DNA No translation available. BC118534 mRNA Translation: AAI18535.1 AK173134 mRNA Translation: BAD32412.1 |
CCDSi | CCDS26641.1 [Q3U1U7-1] CCDS84037.1 [Q3U1U7-2] |
RefSeqi | NP_001304280.1, NM_001317351.1 NP_033774.1, NM_009644.3 XP_006517111.1, XM_006517048.1 XP_006517112.1, XM_006517049.3 XP_006517113.1, XM_006517050.2 |
3D structure databases
SMRi | Q3U1U7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198038, 4 interactors |
CORUMi | Q3U1U7 |
STRINGi | 10090.ENSMUSP00000022059 |
PTM databases
iPTMneti | Q3U1U7 |
PhosphoSitePlusi | Q3U1U7 |
Proteomic databases
MaxQBi | Q3U1U7 |
PaxDbi | Q3U1U7 |
PRIDEi | Q3U1U7 |
ProteomicsDBi | 281958 [Q3U1U7-1] 281959 [Q3U1U7-2] 281960 [Q3U1U7-3] |
Protocols and materials databases
DNASUi | 11624 |
Genome annotation databases
GeneIDi | 11624 |
KEGGi | mmu:11624 |
UCSCi | uc007rev.1, mouse [Q3U1U7-1] uc007rex.1, mouse [Q3U1U7-3] |
Organism-specific databases
CTDi | 57491 |
MGIi | MGI:1333776, Ahrr |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3560, Eukaryota |
InParanoidi | Q3U1U7 |
OrthoDBi | 325707at2759 |
PhylomeDBi | Q3U1U7 |
TreeFami | TF352074 |
Enzyme and pathway databases
Reactomei | R-MMU-211945, Phase I - Functionalization of compounds R-MMU-211976, Endogenous sterols R-MMU-211981, Xenobiotics R-MMU-8937144, Aryl hydrocarbon receptor signalling |
Miscellaneous databases
BioGRID-ORCSi | 11624, 0 hits in 63 CRISPR screens |
ChiTaRSi | Cyp1a1, mouse |
PROi | PR:Q3U1U7 |
RNActi | Q3U1U7, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR039091, AHR/AHRR IPR039092, AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF3, PTHR10649:SF3, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AHRR_MOUSE | |
Accessioni | Q3U1U7Primary (citable) accession number: Q3U1U7 Secondary accession number(s): Q147Z5 Q9Z312 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot