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Protein

Aryl hydrocarbon receptor repressor

Gene

Ahrr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of protein sumoylation Source: BHF-UCL
  • response to xenobiotic stimulus Source: GO_Central
  • xenobiotic metabolic process Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor repressor
Short name:
AhR repressor
Short name:
AhRR
Gene namesi
Name:Ahrr
Synonyms:Kiaa1234
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1333776 Ahrr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338581 – 701Aryl hydrocarbon receptor repressorAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ3U1U7
PaxDbiQ3U1U7
PRIDEiQ3U1U7

PTM databases

iPTMnetiQ3U1U7
PhosphoSitePlusiQ3U1U7

Expressioni

Inductioni

By 3MC. Up-regulated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and beta-naphthoflavone in pituitary.2 Publications

Interactioni

Subunit structurei

Interacts with ARNT, ANKRA2, HDAC4 and HDAC5. Interacts with ARNT; forms a heterodimer with ARNT (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198038, 4 interactors
CORUMiQ3U1U7
STRINGi10090.ENSMUSP00000022059

Structurei

3D structure databases

ProteinModelPortaliQ3U1U7
SMRiQ3U1U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 78bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini106 – 176PASPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni555 – 701Needed for transcriptional repressionAdd BLAST147

Phylogenomic databases

eggNOGiKOG3560 Eukaryota
ENOG410XRZH LUCA
HOGENOMiHOG000033866
HOVERGENiHBG073122
InParanoidiQ3U1U7
KOiK09094
PhylomeDBiQ3U1U7
TreeFamiTF352074

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR039091 AHR/AHRR
IPR039092 AHRR
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PANTHERiPTHR10649 PTHR10649, 1 hit
PTHR10649:SF3 PTHR10649:SF3, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U1U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMIPSGECTY AGRKRRKPIQ KRRLTMGAEK SNPSKRHRDR LNTELDHLAS
60 70 80 90 100
LLPFSPDIIS KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEEH
110 120 130 140 150
SYRGFPVQEG RLLLESLNGF ALVVSAEGMI FYASATIVDY LGFHQTDVMH
160 170 180 190 200
QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF GQSPHADTDN TVLGKLLRAQ
210 220 230 240 250
EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK LKFLFGQKKK
260 270 280 290 300
TPSGTALPPR LSLFCIVAPV LPSVTEMKMK STFLKAKHRA DIVVTMDSRA
310 320 330 340 350
KAVTSLCESE LHPKLNYLAG KSNGENGISL FRGQTDRSHW ARALARSSCL
360 370 380 390 400
CLRGGPDLLD PKGTSGDREE EDQKHILRRS PGAWGQREMH KYSYGLETPV
410 420 430 440 450
HLRHLNWSTE QRSQESTTKL TRQPSKNEPS TCLVPHGSCV PYPGSQGMLS
460 470 480 490 500
ASNMASFRDS LDHPTGAYCS QMNRPLSDIH QGQVDPSTCH ISQGSLGSRI
510 520 530 540 550
PLTGMQRFTA RGFSTEDAKL PSLPVTIGTP CNPVLSLDVP IKMENESGSQ
560 570 580 590 600
DIVEASTTSC LWLGTSDMAR GHLVGFPARM HLKTEPDYRQ QACTPHLGHG
610 620 630 640 650
MLGTNPYSRD TVGSCREHAP LYSAHCTCLD PEPPHHLFMC SHSESQHPSL
660 670 680 690 700
DQDCRAPIVK REPLDSPSWA APGQVTVPRM FPKSASKTVI PSKGSDGIFL

P
Length:701
Mass (Da):77,726
Last modified:October 11, 2005 - v1
Checksum:iA440A214C2AEF6E6
GO
Isoform 2 (identifier: Q3U1U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.
Show »
Length:573
Mass (Da):63,287
Checksum:i6C1A33B26BDF3A3F
GO
Isoform 3 (identifier: Q3U1U7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-701: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):33,807
Checksum:iFD5B35AC15B09EE1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J020A0A0R4J020_MOUSE
Aryl hydrocarbon receptor repressor
Ahrr mCG_20962
701Annotation score:
A0A0R4J1D3A0A0R4J1D3_MOUSE
Aryl hydrocarbon receptor repressor
Ahrr
573Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3I → V in BAE32810 (PubMed:16141072).Curated1
Sequence conflicti637L → F in BAA37132 (PubMed:9887096).Curated1
Sequence conflicti637L → F in BAE32410 (PubMed:16141072).Curated1
Sequence conflicti637L → F in BAE32810 (PubMed:16141072).Curated1
Sequence conflicti637L → F in AAI18535 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335651 – 128Missing in isoform 2. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_033566300 – 701Missing in isoform 3. 1 PublicationAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015140 mRNA Translation: BAA37132.1
AK154152 mRNA Translation: BAE32410.1
AK154761 mRNA Translation: BAE32810.1
AK155711 mRNA Translation: BAE33396.1
CT009486, AC123833 Genomic DNA Translation: CAO77884.1
BC118534 mRNA Translation: AAI18535.1
AK173134 mRNA Translation: BAD32412.1
CCDSiCCDS26641.1 [Q3U1U7-1]
CCDS84037.1 [Q3U1U7-2]
RefSeqiNP_001304280.1, NM_001317351.1
NP_033774.1, NM_009644.3
XP_006517111.1, XM_006517048.1
XP_006517112.1, XM_006517049.3
XP_006517113.1, XM_006517050.2
UniGeneiMm.290446

Genome annotation databases

GeneIDi11624
KEGGimmu:11624
UCSCiuc007rev.1 mouse [Q3U1U7-1]
uc007rex.1 mouse [Q3U1U7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015140 mRNA Translation: BAA37132.1
AK154152 mRNA Translation: BAE32410.1
AK154761 mRNA Translation: BAE32810.1
AK155711 mRNA Translation: BAE33396.1
CT009486, AC123833 Genomic DNA Translation: CAO77884.1
BC118534 mRNA Translation: AAI18535.1
AK173134 mRNA Translation: BAD32412.1
CCDSiCCDS26641.1 [Q3U1U7-1]
CCDS84037.1 [Q3U1U7-2]
RefSeqiNP_001304280.1, NM_001317351.1
NP_033774.1, NM_009644.3
XP_006517111.1, XM_006517048.1
XP_006517112.1, XM_006517049.3
XP_006517113.1, XM_006517050.2
UniGeneiMm.290446

3D structure databases

ProteinModelPortaliQ3U1U7
SMRiQ3U1U7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198038, 4 interactors
CORUMiQ3U1U7
STRINGi10090.ENSMUSP00000022059

PTM databases

iPTMnetiQ3U1U7
PhosphoSitePlusiQ3U1U7

Proteomic databases

MaxQBiQ3U1U7
PaxDbiQ3U1U7
PRIDEiQ3U1U7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11624
KEGGimmu:11624
UCSCiuc007rev.1 mouse [Q3U1U7-1]
uc007rex.1 mouse [Q3U1U7-3]

Organism-specific databases

CTDi57491
MGIiMGI:1333776 Ahrr
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3560 Eukaryota
ENOG410XRZH LUCA
HOGENOMiHOG000033866
HOVERGENiHBG073122
InParanoidiQ3U1U7
KOiK09094
PhylomeDBiQ3U1U7
TreeFamiTF352074

Miscellaneous databases

PROiPR:Q3U1U7
SOURCEiSearch...

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR039091 AHR/AHRR
IPR039092 AHRR
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PANTHERiPTHR10649 PTHR10649, 1 hit
PTHR10649:SF3 PTHR10649:SF3, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAHRR_MOUSE
AccessioniPrimary (citable) accession number: Q3U1U7
Secondary accession number(s): Q147Z5
, Q3U3H6, Q69ZN4, Q9Z312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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