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Protein

TCF3 fusion partner homolog

Gene

Tfpt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to promote apoptosis in a p53/TP53-independent manner.By similarity
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
TCF3 fusion partner homolog
Alternative name(s):
Protein FB1
Protein amida
Gene namesi
Name:Tfpt
Synonyms:Amida
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916964 Tfpt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545821 – 259TCF3 fusion partner homologAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei172PhosphothreonineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei203PhosphothreonineBy similarity1
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3U1J1
PaxDbiQ3U1J1
PeptideAtlasiQ3U1J1
PRIDEiQ3U1J1

PTM databases

iPTMnetiQ3U1J1
PhosphoSitePlusiQ3U1J1

Expressioni

Gene expression databases

BgeeiENSMUSG00000006335 Expressed in 267 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_TFPT
ExpressionAtlasiQ3U1J1 baseline and differential
GenevisibleiQ3U1J1 MM

Interactioni

Subunit structurei

Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213632, 1 interactor
ComplexPortaliCPX-878 INO80 chromatin remodeling complex
IntActiQ3U1J1, 1 interactor
STRINGi10090.ENSMUSP00000123636

Structurei

3D structure databases

ProteinModelPortaliQ3U1J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXD0 Eukaryota
ENOG4111UBX LUCA
GeneTreeiENSGT00390000016605
HOGENOMiHOG000139148
HOVERGENiHBG056588
InParanoidiQ3U1J1
KOiK11670
OMAiFTIMLED
OrthoDBiEOG091G0WHN
PhylomeDBiQ3U1J1
TreeFamiTF338152

Family and domain databases

InterProiView protein in InterPro
IPR033555 TFPT
PANTHERiPTHR35084 PTHR35084, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U1J1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG
60 70 80 90 100
GLGDSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL
110 120 130 140 150
NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRDSQFTIVL EDDGSQGTDV
160 170 180 190 200
PTPGNAENEP PEKEGLSPSQ RTTATLDPTS PAPGEGPSGR KRRRAPRVGA
210 220 230 240 250
SLTPELAPVQ VGAEGWGQGV IKVEEDFGFE ADEALDSSWV SREPDKLLPY

PTLASPPFD
Length:259
Mass (Da):28,954
Last modified:October 11, 2005 - v1
Checksum:iC5A0094DC93B356A
GO
Isoform 2 (identifier: Q3U1J1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-220: Missing.

Show »
Length:249
Mass (Da):28,013
Checksum:iA5D01527808DEA57
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIZ9F8WIZ9_MOUSE
TCF3 fusion partner homolog
Tfpt
156Annotation score:
A0A0U1RPD5A0A0U1RPD5_MOUSE
TCF3 fusion partner homolog
Tfpt
84Annotation score:
A0A0U1RQ56A0A0U1RQ56_MOUSE
TCF3 fusion partner homolog
Tfpt
97Annotation score:
D6RHM4D6RHM4_MOUSE
TCF3 fusion partner homolog
Tfpt
45Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021243211 – 220Missing in isoform 2. 3 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267988 mRNA Translation: AAG48243.1
AB035134 mRNA Translation: BAB17318.1
AK155925 mRNA Translation: BAE33506.1
BC024356 mRNA Translation: AAH24356.1
CCDSiCCDS20720.1 [Q3U1J1-2]
CCDS71873.1 [Q3U1J1-1]
RefSeqiNP_001277310.1, NM_001290381.1 [Q3U1J1-1]
NP_076013.1, NM_023524.2 [Q3U1J1-2]
UniGeneiMm.358730

Genome annotation databases

EnsembliENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335 [Q3U1J1-1]
ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335 [Q3U1J1-2]
GeneIDi69714
KEGGimmu:69714
UCSCiuc009evf.2 mouse [Q3U1J1-2]
uc009evg.2 mouse [Q3U1J1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267988 mRNA Translation: AAG48243.1
AB035134 mRNA Translation: BAB17318.1
AK155925 mRNA Translation: BAE33506.1
BC024356 mRNA Translation: AAH24356.1
CCDSiCCDS20720.1 [Q3U1J1-2]
CCDS71873.1 [Q3U1J1-1]
RefSeqiNP_001277310.1, NM_001290381.1 [Q3U1J1-1]
NP_076013.1, NM_023524.2 [Q3U1J1-2]
UniGeneiMm.358730

3D structure databases

ProteinModelPortaliQ3U1J1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213632, 1 interactor
ComplexPortaliCPX-878 INO80 chromatin remodeling complex
IntActiQ3U1J1, 1 interactor
STRINGi10090.ENSMUSP00000123636

PTM databases

iPTMnetiQ3U1J1
PhosphoSitePlusiQ3U1J1

Proteomic databases

MaxQBiQ3U1J1
PaxDbiQ3U1J1
PeptideAtlasiQ3U1J1
PRIDEiQ3U1J1

Protocols and materials databases

DNASUi69714
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335 [Q3U1J1-1]
ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335 [Q3U1J1-2]
GeneIDi69714
KEGGimmu:69714
UCSCiuc009evf.2 mouse [Q3U1J1-2]
uc009evg.2 mouse [Q3U1J1-1]

Organism-specific databases

CTDi29844
MGIiMGI:1916964 Tfpt

Phylogenomic databases

eggNOGiENOG410IXD0 Eukaryota
ENOG4111UBX LUCA
GeneTreeiENSGT00390000016605
HOGENOMiHOG000139148
HOVERGENiHBG056588
InParanoidiQ3U1J1
KOiK11670
OMAiFTIMLED
OrthoDBiEOG091G0WHN
PhylomeDBiQ3U1J1
TreeFamiTF338152

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER

Miscellaneous databases

PROiPR:Q3U1J1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006335 Expressed in 267 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_TFPT
ExpressionAtlasiQ3U1J1 baseline and differential
GenevisibleiQ3U1J1 MM

Family and domain databases

InterProiView protein in InterPro
IPR033555 TFPT
PANTHERiPTHR35084 PTHR35084, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTFPT_MOUSE
AccessioniPrimary (citable) accession number: Q3U1J1
Secondary accession number(s): Q9EP77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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