UniProtKB - Q3U1J1 (TFPT_MOUSE)
TCF3 fusion partner homolog
Tfpt
Functioni
Appears to promote apoptosis in a p53/TP53-independent manner.
By similarityPutative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
GO - Molecular functioni
- DNA binding Source: UniProtKB
- protein-containing complex binding Source: MGI
- protein kinase binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB
- apoptotic signaling pathway Source: UniProtKB
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- male gonad development Source: Ensembl
- nucleosome mobilization Source: Ensembl
- positive regulation of apoptotic process Source: MGI
- positive regulation of DNA repair Source: ComplexPortal
- positive regulation of telomere maintenance in response to DNA damage Source: ComplexPortal
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of cell cycle Source: Ensembl
- regulation of DNA repair Source: ComplexPortal
- regulation of DNA replication Source: Ensembl
- regulation of DNA strand elongation Source: Ensembl
- regulation of embryonic development Source: ComplexPortal
- telomere maintenance Source: ComplexPortal
Keywordsi
Biological process | Apoptosis, DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-5689603, UCH proteinases R-MMU-5696394, DNA Damage Recognition in GG-NER |
Names & Taxonomyi
Protein namesi | Recommended name: TCF3 fusion partner homologAlternative name(s): Protein FB1 Protein amida |
Gene namesi | Name:Tfpt Synonyms:Amida |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916964, Tfpt |
VEuPathDBi | HostDB:ENSMUSG00000006335 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- actin filament Source: Ensembl
Nucleus
- Ino80 complex Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254582 | 1 – 259 | TCF3 fusion partner homologAdd BLAST | 259 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Modified residuei | 172 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 180 | PhosphoserineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 | |
Modified residuei | 203 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 222 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 255 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q3U1J1 |
MaxQBi | Q3U1J1 |
PaxDbi | Q3U1J1 |
PeptideAtlasi | Q3U1J1 |
PRIDEi | Q3U1J1 |
ProteomicsDBi | 262804 [Q3U1J1-1] 262805 [Q3U1J1-2] |
PTM databases
iPTMneti | Q3U1J1 |
PhosphoSitePlusi | Q3U1J1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000006335, Expressed in supraoptic nucleus and 293 other tissues |
Genevisiblei | Q3U1J1, MM |
Interactioni
Subunit structurei
Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death.
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (By similarity).
By similarityGO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 213632, 1 interactor |
ComplexPortali | CPX-878, INO80 chromatin remodeling complex |
IntActi | Q3U1J1, 1 interactor |
STRINGi | 10090.ENSMUSP00000104281 |
Miscellaneous databases
RNActi | Q3U1J1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 72 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 141 – 210 | DisorderedSequence analysisAdd BLAST | 70 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 72 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 165 – 179 | Polar residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | ENOG502RHUP, Eukaryota |
GeneTreei | ENSGT00390000016605 |
HOGENOMi | CLU_096140_0_0_1 |
InParanoidi | Q3U1J1 |
OMAi | NEPPDKE |
OrthoDBi | 1308382at2759 |
PhylomeDBi | Q3U1J1 |
TreeFami | TF338152 |
Family and domain databases
InterProi | View protein in InterPro IPR033555, TFPT |
PANTHERi | PTHR35084, PTHR35084, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG
60 70 80 90 100
GLGDSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL
110 120 130 140 150
NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRDSQFTIVL EDDGSQGTDV
160 170 180 190 200
PTPGNAENEP PEKEGLSPSQ RTTATLDPTS PAPGEGPSGR KRRRAPRVGA
210 220 230 240 250
SLTPELAPVQ VGAEGWGQGV IKVEEDFGFE ADEALDSSWV SREPDKLLPY
PTLASPPFD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WIZ9 | F8WIZ9_MOUSE | TCF3 fusion partner homolog | Tfpt | 156 | Annotation score: | ||
A0A0U1RPD5 | A0A0U1RPD5_MOUSE | TCF3 fusion partner homolog | Tfpt | 84 | Annotation score: | ||
A0A0U1RQ56 | A0A0U1RQ56_MOUSE | TCF3 fusion partner homolog | Tfpt | 97 | Annotation score: | ||
D6RHM4 | D6RHM4_MOUSE | TCF3 fusion partner homolog | Tfpt | 45 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021243 | 211 – 220 | Missing in isoform 2. 3 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF267988 mRNA Translation: AAG48243.1 AB035134 mRNA Translation: BAB17318.1 AK155925 mRNA Translation: BAE33506.1 BC024356 mRNA Translation: AAH24356.1 |
CCDSi | CCDS20720.1 [Q3U1J1-2] CCDS71873.1 [Q3U1J1-1] |
RefSeqi | NP_001277310.1, NM_001290381.1 [Q3U1J1-1] NP_076013.1, NM_023524.2 [Q3U1J1-2] |
Genome annotation databases
Ensembli | ENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335 [Q3U1J1-1] ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335 [Q3U1J1-2] |
GeneIDi | 69714 |
KEGGi | mmu:69714 |
UCSCi | uc009evf.2, mouse [Q3U1J1-2] uc009evg.2, mouse [Q3U1J1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF267988 mRNA Translation: AAG48243.1 AB035134 mRNA Translation: BAB17318.1 AK155925 mRNA Translation: BAE33506.1 BC024356 mRNA Translation: AAH24356.1 |
CCDSi | CCDS20720.1 [Q3U1J1-2] CCDS71873.1 [Q3U1J1-1] |
RefSeqi | NP_001277310.1, NM_001290381.1 [Q3U1J1-1] NP_076013.1, NM_023524.2 [Q3U1J1-2] |
3D structure databases
SMRi | Q3U1J1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 213632, 1 interactor |
ComplexPortali | CPX-878, INO80 chromatin remodeling complex |
IntActi | Q3U1J1, 1 interactor |
STRINGi | 10090.ENSMUSP00000104281 |
PTM databases
iPTMneti | Q3U1J1 |
PhosphoSitePlusi | Q3U1J1 |
Proteomic databases
jPOSTi | Q3U1J1 |
MaxQBi | Q3U1J1 |
PaxDbi | Q3U1J1 |
PeptideAtlasi | Q3U1J1 |
PRIDEi | Q3U1J1 |
ProteomicsDBi | 262804 [Q3U1J1-1] 262805 [Q3U1J1-2] |
Protocols and materials databases
Antibodypediai | 32793, 155 antibodies from 28 providers |
DNASUi | 69714 |
Genome annotation databases
Ensembli | ENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335 [Q3U1J1-1] ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335 [Q3U1J1-2] |
GeneIDi | 69714 |
KEGGi | mmu:69714 |
UCSCi | uc009evf.2, mouse [Q3U1J1-2] uc009evg.2, mouse [Q3U1J1-1] |
Organism-specific databases
CTDi | 29844 |
MGIi | MGI:1916964, Tfpt |
VEuPathDBi | HostDB:ENSMUSG00000006335 |
Phylogenomic databases
eggNOGi | ENOG502RHUP, Eukaryota |
GeneTreei | ENSGT00390000016605 |
HOGENOMi | CLU_096140_0_0_1 |
InParanoidi | Q3U1J1 |
OMAi | NEPPDKE |
OrthoDBi | 1308382at2759 |
PhylomeDBi | Q3U1J1 |
TreeFami | TF338152 |
Enzyme and pathway databases
Reactomei | R-MMU-5689603, UCH proteinases R-MMU-5696394, DNA Damage Recognition in GG-NER |
Miscellaneous databases
BioGRID-ORCSi | 69714, 9 hits in 104 CRISPR screens |
PROi | PR:Q3U1J1 |
RNActi | Q3U1J1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006335, Expressed in supraoptic nucleus and 293 other tissues |
Genevisiblei | Q3U1J1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR033555, TFPT |
PANTHERi | PTHR35084, PTHR35084, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TFPT_MOUSE | |
Accessioni | Q3U1J1Primary (citable) accession number: Q3U1J1 Secondary accession number(s): Q9EP77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot