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UniProtKB - Q3U1C2 (Q3U1C2_MOUSE)
Protein
RuvB-like helicase
Gene
Ruvbl1
Organism
Mus musculus (Mouse)
Status
Functioni
Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
UniRule annotationCatalytic activityi
GO - Molecular functioni
- 5'-3' DNA helicase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: Ensembl
- TBP-class protein binding Source: Ensembl
- transcription coactivator activity Source: Ensembl
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- histone H2A acetylation Source: Ensembl
- histone H4 acetylation Source: Ensembl
- nucleosome mobilization Source: Ensembl
- positive regulation of canonical Wnt signaling pathway Source: Ensembl
- positive regulation of double-strand break repair via homologous recombination Source: Ensembl
- regulation of cell cycle Source: Ensembl
- regulation of chromosome organization Source: Ensembl
- regulation of DNA replication Source: Ensembl
- regulation of DNA strand elongation Source: Ensembl
Keywordsi
Molecular function | HelicaseUniRule annotation, Hydrolase |
Biological process | DNA damage, DNA recombinationUniRule annotationARBA annotation, DNA repairUniRule annotationARBA annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ruvbl1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1928760, Ruvbl1 |
VEuPathDBi | HostDB:ENSMUSG00000030079 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Other locations
- Dynein axonemal particle ARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- Ino80 complex Source: Ensembl
- MLL1 complex Source: Ensembl
- NuA4 histone acetyltransferase complex Source: Ensembl
- Swr1 complex Source: Ensembl
Other locations
- chaperone complex Source: Ensembl
- dynein axonemal particle Source: UniProtKB-SubCell
- nucleosome Source: Ensembl
- R2TP complex Source: Ensembl
- RPAP3/R2TP/prefoldin-like complex Source: Ensembl
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030079, Expressed in limb and 87 other tissues |
Interactioni
GO - Molecular functioni
- TBP-class protein binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q3U1C2, 1 interactor |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 365 | AAAInterPro annotationAdd BLAST | 304 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_028311_1_1_1 |
OMAi | VIYVEAN |
OrthoDBi | 752343at2759 |
Family and domain databases
Gene3Di | 2.40.50.360, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR027238, RuvB-like IPR041048, RuvB-like_C IPR037938, RUVBL1 IPR042487, RuvBL1/2_DNA/RNA_bd_dom IPR010339, TIP49_P-loop |
PANTHERi | PTHR11093, PTHR11093, 1 hit PTHR11093:SF6, PTHR11093:SF6, 1 hit |
Pfami | View protein in Pfam PF06068, TIP49, 1 hit PF17856, TIP49_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U1C2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG
60 70 80 90 100
VIVELIKSKK MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE
110 120 130 140 150
VYSTEIKKTE VLMENFRRAI GLRIKETKEV YEGEVTELTP CETENPMGGY
160 170 180 190 200
GKTISHVIIG LKTAKGTKQL KLDPSIFESL QKERVEAGDV IYIEANSGAV
210 220 230 240 250
KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL HDLDVANARP
260 270 280 290 300
QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG VAELVPGVLF
310 320 330 340 350
VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI
360 370 380 390 400
PLDLLDRVMI IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK
410 420 430 440 450
TTLRYSVQLL TPANLLAKIN GKDSIEKEHV EEISELFYDA KSSAKILADQ
QDKYMK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK132783 mRNA Translation: BAE21358.1 AK156078 mRNA Translation: BAE33576.1 |
RefSeqi | NP_062659.1, NM_019685.3 |
Genome annotation databases
GeneIDi | 56505 |
KEGGi | mmu:56505 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK132783 mRNA Translation: BAE21358.1 AK156078 mRNA Translation: BAE33576.1 |
RefSeqi | NP_062659.1, NM_019685.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q3U1C2, 1 interactor |
Protocols and materials databases
Antibodypediai | 17283, 380 antibodies from 34 providers |
DNASUi | 56505 |
Genome annotation databases
GeneIDi | 56505 |
KEGGi | mmu:56505 |
Organism-specific databases
CTDi | 8607 |
MGIi | MGI:1928760, Ruvbl1 |
VEuPathDBi | HostDB:ENSMUSG00000030079 |
Phylogenomic databases
HOGENOMi | CLU_028311_1_1_1 |
OMAi | VIYVEAN |
OrthoDBi | 752343at2759 |
Miscellaneous databases
BioGRID-ORCSi | 56505, 40 hits in 99 CRISPR screens |
ChiTaRSi | Ruvbl1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030079, Expressed in limb and 87 other tissues |
Family and domain databases
Gene3Di | 2.40.50.360, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR027238, RuvB-like IPR041048, RuvB-like_C IPR037938, RUVBL1 IPR042487, RuvBL1/2_DNA/RNA_bd_dom IPR010339, TIP49_P-loop |
PANTHERi | PTHR11093, PTHR11093, 1 hit PTHR11093:SF6, PTHR11093:SF6, 1 hit |
Pfami | View protein in Pfam PF06068, TIP49, 1 hit PF17856, TIP49_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U1C2_MOUSE | |
Accessioni | Q3U1C2Primary (citable) accession number: Q3U1C2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | January 19, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |