UniProtKB - Q3U0Y6 (Q3U0Y6_MOUSE)
Protein
Interleukin-1
Gene
Il1a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- copper ion binding Source: Ensembl
- cytokine activity Source: UniProtKB-UniRule
- interleukin-1 receptor binding Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to heat Source: Ensembl
- cytokine-mediated signaling pathway Source: Ensembl
- fever generation Source: UniProtKB-UniRule
- immune response Source: InterPro
- negative regulation of cell population proliferation Source: Ensembl
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cytokine secretion Source: Ensembl
- positive regulation of interleukin-2 production Source: Ensembl
- positive regulation of mitotic nuclear division Source: Ensembl
- response to copper ion Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotationARBA annotation, MitogenUniRule annotationARBA annotation, PyrogenUniRule annotationARBA annotation |
Biological process | Inflammatory response |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-1UniRule annotation |
Gene namesi | Name:Il1aImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:96542, Il1a |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB-UniRule
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotation, SecretedUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000027399, Expressed in liver and 53 other tissues |
ExpressionAtlasi | Q3U0Y6, baseline and differential |
Interactioni
Subunit structurei
Monomer.
UniRule annotationGO - Molecular functioni
- cytokine activity Source: UniProtKB-UniRule
- interleukin-1 receptor binding Source: UniProtKB-UniRule
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 110 | IL1_propepInterPro annotationAdd BLAST | 110 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_090014_0_0_1 |
OMAi | QKSFYDA |
OrthoDBi | 1513671at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003295, IL-1_alpha IPR020877, IL-1_CS IPR000975, IL-1_fam IPR003502, IL-1_propep IPR008996, IL1/FGF |
PANTHERi | PTHR10078, PTHR10078, 1 hit PTHR10078:SF33, PTHR10078:SF33, 1 hit |
Pfami | View protein in Pfam PF00340, IL1, 1 hit PF02394, IL1_propep, 1 hit |
PRINTSi | PR00264, INTERLEUKIN1 PR01358, INTRLEUKIN1A |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00253, INTERLEUKIN_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U0Y6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ
60 70 80 90 100
FVSLRTSETS KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL
110 120 130 140 150
QSITHDLEET IQPRSAPYTY QSDLRYKLMK LVRQKFVMND SLNQTIYQDV
160 170 180 190 200
DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD SKYPVTLKIS DSQLFVSAQG
210 220 230 240 250
EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA AYPELFIATK
260 270
EQSRVHLARG LPSMTDFQIS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY902318 Genomic DNA Translation: AAX90603.1 AK156449 mRNA Translation: BAE33715.1 |
RefSeqi | NP_034684.2, NM_010554.4 XP_006498856.1, XM_006498793.3 |
Genome annotation databases
GeneIDi | 16175 |
KEGGi | mmu:16175 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY902318 Genomic DNA Translation: AAX90603.1 AK156449 mRNA Translation: BAE33715.1 |
RefSeqi | NP_034684.2, NM_010554.4 XP_006498856.1, XM_006498793.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3842, 1412 antibodies |
Genome annotation databases
GeneIDi | 16175 |
KEGGi | mmu:16175 |
Organism-specific databases
CTDi | 3552 |
MGIi | MGI:96542, Il1a |
Phylogenomic databases
HOGENOMi | CLU_090014_0_0_1 |
OMAi | QKSFYDA |
OrthoDBi | 1513671at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16175, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027399, Expressed in liver and 53 other tissues |
ExpressionAtlasi | Q3U0Y6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003295, IL-1_alpha IPR020877, IL-1_CS IPR000975, IL-1_fam IPR003502, IL-1_propep IPR008996, IL1/FGF |
PANTHERi | PTHR10078, PTHR10078, 1 hit PTHR10078:SF33, PTHR10078:SF33, 1 hit |
Pfami | View protein in Pfam PF00340, IL1, 1 hit PF02394, IL1_propep, 1 hit |
PRINTSi | PR00264, INTERLEUKIN1 PR01358, INTRLEUKIN1A |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00253, INTERLEUKIN_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U0Y6_MOUSE | |
Accessioni | Q3U0Y6Primary (citable) accession number: Q3U0Y6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |