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Entry version 145 (02 Dec 2020)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Zinc finger protein 217

Gene

Zfp217

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 217Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfp217Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685408, Zfp217

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052056, Expressed in blood and 212 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q3U0X6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104783

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 148C2H2-typeInterPro annotationAdd BLAST28
Domaini149 – 176C2H2-typeInterPro annotationAdd BLAST28
Domaini208 – 235C2H2-typeInterPro annotationAdd BLAST28
Domaini383 – 410C2H2-typeInterPro annotationAdd BLAST28
Domaini478 – 505C2H2-typeInterPro annotationAdd BLAST28
Domaini506 – 534C2H2-typeInterPro annotationAdd BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni304 – 383DisorderedSequence analysisAdd BLAST80
Regioni402 – 477DisorderedSequence analysisAdd BLAST76
Regioni526 – 552DisorderedSequence analysisAdd BLAST27
Regioni728 – 881DisorderedSequence analysisAdd BLAST154
Regioni902 – 929DisorderedSequence analysisAdd BLAST28
Regioni999 – 1041DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi304 – 331PolyampholyteSequence analysisAdd BLAST28
Compositional biasi353 – 367PolyampholyteSequence analysisAdd BLAST15
Compositional biasi442 – 473PolyampholyteSequence analysisAdd BLAST32
Compositional biasi526 – 547PolyampholyteSequence analysisAdd BLAST22
Compositional biasi792 – 834PolarSequence analysisAdd BLAST43
Compositional biasi857 – 876PolarSequence analysisAdd BLAST20
Compositional biasi1011 – 1031PolarSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159884

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010747_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGCMPLD

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332241

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3U0X6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTQSLLVYM DGPEVLSSSL GSQMEVDDAV PIKGPVAVPF RAAQEKSMAV
60 70 80 90 100
AEGHMPLDCM FCSQVFSQAE DLSQHVLLQH RPTLCEPAVL RVEAEYLSPL
110 120 130 140 150
DKALEPTEPA LEKSGEDPEE LSCDVCGQTF PVAFDVESHM KKHKDSFTYG
160 170 180 190 200
CSMCGRRFKE PWFLKNHMRT HNGKSGTRSK LQQGMESPVT INEVVQPHAP
210 220 230 240 250
GSISTPYKIC MVCGFLFPNK QSLIEHSKVH AKETVPSASN VAPDDHREEP
260 270 280 290 300
TSPREELLQF LNLRPRSTAG STVKPMTCIP QLDPFTTYQA WQLATKGKVA
310 320 330 340 350
VAQEEVKESG QEGSTDNDDS CSEKEELGEI WVGGKAEGSG KSKTSKSSCP
360 370 380 390 400
GLSQDKEKPR HANSEVPSGD SDPKLSSSKE KPTHCSECSK AFRTYHQLVL
410 420 430 440 450
HSRVHRKDRR TDALSPTMAV DARQPGTCSP DLSTTLEDSG AGDREGGSED
460 470 480 490 500
GSEDGLPDGL HLDKNDDGGK AKPLPSSREC SYCGKFFRSN YYLNIHLRTH
510 520 530 540 550
TGEKPYKCEF CEYAAAQKTS LRYHLERHHK DKQPVDAAAE SKSEGRSQEP
560 570 580 590 600
QDALLTAADS AQTKNLKRFL DGAKDVKGSP PAKQLKEMPS VFQSVLSPAH
610 620 630 640 650
SNDTQDFHKH AADSAEKARK SPAPTYLDMQ RKKAGEPQAS SPVCRLEGVG
660 670 680 690 700
SLAREAGHRE KMDQDADYRH KPGADCQDRP LNLSLGPLHA CPAISLSKCL
710 720 730 740 750
IPSIACPFCT FKTFYPEVLM MHQRLEHRYN PDPHKNGSSK SVLRNRRTGC
760 770 780 790 800
PPALLGKDVP PLSGLHKPKA KTAFSPHSKS LHSEKARQGA SGPSKAPQTS
810 820 830 840 850
GPDNSTLAPS NLKSHRSQPN AGGTSATRQQ QSELFPKGGV PAAMDKVKRP
860 870 880 890 900
EPKLKSLPAS PSQSPLSSNN SNGSVEYPVK VDGPWAQQGR DYYCHRNSGS
910 920 930 940 950
AAAEYSEPHP KRLKSSAVSL DTEHAGTNGR RGFELPKYHV VRSITSLLPP
960 970 980 990 1000
ECVRPPPVLP HKARFLSPGE VESPSVLAVQ KPYSASGPLY TCGPVGHAGG
1010 1020 1030 1040
SPALEGKRPV SHQHLSNSML QKRSYENFIG NTHYRPNDKK P
Length:1,041
Mass (Da):113,600
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i610BB8BCC936C50D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844576 Genomic DNA No translation available.
BC116329 mRNA Translation: AAI16330.1
BC116330 mRNA Translation: AAI16331.1
AK156475 mRNA Translation: BAE33725.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028471.1, NM_001033299.3
NP_001153155.1, NM_001159683.1
XP_006499490.1, XM_006499427.3
XP_006499491.1, XM_006499428.2
XP_006499492.1, XM_006499429.3
XP_006499493.1, XM_006499430.2
XP_006499494.1, XM_006499431.2
XP_006499495.1, XM_006499432.3
XP_006499496.1, XM_006499433.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000063710; ENSMUSP00000067334; ENSMUSG00000052056
ENSMUST00000109155; ENSMUSP00000104783; ENSMUSG00000052056

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228913

UCSC genome browser

More...
UCSCi
uc008obu.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844576 Genomic DNA No translation available.
BC116329 mRNA Translation: AAI16330.1
BC116330 mRNA Translation: AAI16331.1
AK156475 mRNA Translation: BAE33725.1
RefSeqiNP_001028471.1, NM_001033299.3
NP_001153155.1, NM_001159683.1
XP_006499490.1, XM_006499427.3
XP_006499491.1, XM_006499428.2
XP_006499492.1, XM_006499429.3
XP_006499493.1, XM_006499430.2
XP_006499494.1, XM_006499431.2
XP_006499495.1, XM_006499432.3
XP_006499496.1, XM_006499433.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ3U0X6, 1 interactor
STRINGi10090.ENSMUSP00000104783

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28736, 317 antibodies

Genome annotation databases

EnsembliENSMUST00000063710; ENSMUSP00000067334; ENSMUSG00000052056
ENSMUST00000109155; ENSMUSP00000104783; ENSMUSG00000052056
GeneIDi228913
KEGGimmu:228913
UCSCiuc008obu.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
228913
MGIiMGI:2685408, Zfp217

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159884
HOGENOMiCLU_010747_0_0_1
OMAiEGCMPLD
OrthoDBi1318335at2759
TreeFamiTF332241

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
228913, 5 hits in 18 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052056, Expressed in blood and 212 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3U0X6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U0X6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: December 2, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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