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Protein

Far upstream element-binding protein 2

Gene

Khsrp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: MGI
  • mRNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Far upstream element-binding protein 2
Short name:
FUSE-binding protein 2
Alternative name(s):
KH type-splicing regulatory protein
Short name:
KSRP
Gene namesi
Name:Khsrp
Synonyms:Fubp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1336214 Khsrp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002986782 – 748Far upstream element-binding protein 2Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei88N6-acetyllysineCombined sources1
Modified residuei101PhosphothreonineBy similarity1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei126PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei182PhosphoserineCombined sources1
Modified residuei185PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei412Omega-N-methylarginineCombined sources1
Modified residuei414Omega-N-methylarginineCombined sources1
Modified residuei416Omega-N-methylarginineCombined sources1
Modified residuei443Omega-N-methylarginineCombined sources1
Modified residuei481PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3U0V1
MaxQBiQ3U0V1
PaxDbiQ3U0V1
PeptideAtlasiQ3U0V1
PRIDEiQ3U0V1

PTM databases

iPTMnetiQ3U0V1
PhosphoSitePlusiQ3U0V1
SwissPalmiQ3U0V1

Expressioni

Gene expression databases

BgeeiENSMUSG00000007670 Expressed in 236 organ(s), highest expression level in heart
CleanExiMM_KHSRP
GenevisibleiQ3U0V1 MM

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN. Interacts with PQBP1.By similarity

Protein-protein interaction databases

BioGridi200927, 4 interactors
IntActiQ3U0V1, 5 interactors
STRINGi10090.ENSMUSP00000007814

Structurei

3D structure databases

ProteinModelPortaliQ3U0V1
SMRiQ3U0V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 209KH 1PROSITE-ProRule annotationAdd BLAST65
Domaini234 – 300KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini323 – 387KH 3PROSITE-ProRule annotationAdd BLAST65
Domaini425 – 492KH 4PROSITE-ProRule annotationAdd BLAST68
Repeati572 – 5831Add BLAST12
Repeati618 – 6292Add BLAST12
Repeati644 – 6553Add BLAST12
Repeati674 – 6854Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni572 – 6854 X 12 AA imperfect repeatsAdd BLAST114

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 68Gly/Pro-richAdd BLAST62
Compositional biasi69 – 497Gly-richAdd BLAST429
Compositional biasi499 – 613Ala/Gly/Pro-richAdd BLAST115

Sequence similaritiesi

Belongs to the KHSRP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1676 Eukaryota
ENOG410XZYE LUCA
GeneTreeiENSGT00730000110664
HOGENOMiHOG000231552
HOVERGENiHBG000625
InParanoidiQ3U0V1
KOiK13210
OMAiPAGQSDY
OrthoDBiEOG091G073X
TreeFamiTF313654

Family and domain databases

Gene3Di3.30.1370.10, 4 hits
InterProiView protein in InterPro
IPR015096 FUBP_C
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF09005 DUF1897, 2 hits
PF00013 KH_1, 4 hits
SMARTiView protein in SMART
SM00322 KH, 4 hits
SUPFAMiSSF54791 SSF54791, 4 hits
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50084 KH_TYPE_1, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U0V1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDYNTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP
60 70 80 90 100
GGGGASGGPS QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN
110 120 130 140 150
TPDFGFGGQK RQLEDGDQPD SKKLASQGDS IGSQLGPIHP PPRTSMTEEY
160 170 180 190 200
RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ ISPDSGGLPE RSVSLTGAPE
210 220 230 240 250
SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM IPAGKAGLVI
260 270 280 290 300
GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV
310 320 330 340 350
MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ
360 370 380 390 400
NDAGVRIQFK QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG
410 420 430 440 450
PPGAPGMPPG GRGRGRGQGN WGPPGGEMTF SIPTHKCGLV IGRGGENVKA
460 470 480 490 500
INQQTGAFVE ISRQLPPNGD PNFKLFVIRG SPQQIDHAKQ LIEEKIEGPL
510 520 530 540 550
CPVGPGPGGP GPAGPMGPFN PGPFNQGPPG APPHAGGPPP HQYPPQGWGN
560 570 580 590 600
TYPQWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA
610 620 630 640 650
APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE
660 670 680 690 700
EYYKKQAQVA TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ
710 720 730 740
PPPTQQGQQQ ASGNCHPPPP PFSFQPPATV HPALVGSAGN PFPCGVCP
Length:748
Mass (Da):76,775
Last modified:July 27, 2011 - v2
Checksum:i0699217B3E1E54A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti387I → F in BAE33750 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156541 mRNA Translation: BAE33750.1
CT571247 Genomic DNA No translation available.
BC064454 mRNA Translation: AAH64454.1
BC108414 mRNA Translation: AAI08415.1
CCDSiCCDS50157.1
RefSeqiNP_034743.3, NM_010613.3
UniGeneiMm.34296

Genome annotation databases

EnsembliENSMUST00000007814; ENSMUSP00000007814; ENSMUSG00000007670
GeneIDi16549
KEGGimmu:16549
UCSCiuc008ddr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156541 mRNA Translation: BAE33750.1
CT571247 Genomic DNA No translation available.
BC064454 mRNA Translation: AAH64454.1
BC108414 mRNA Translation: AAI08415.1
CCDSiCCDS50157.1
RefSeqiNP_034743.3, NM_010613.3
UniGeneiMm.34296

3D structure databases

ProteinModelPortaliQ3U0V1
SMRiQ3U0V1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200927, 4 interactors
IntActiQ3U0V1, 5 interactors
STRINGi10090.ENSMUSP00000007814

PTM databases

iPTMnetiQ3U0V1
PhosphoSitePlusiQ3U0V1
SwissPalmiQ3U0V1

Proteomic databases

EPDiQ3U0V1
MaxQBiQ3U0V1
PaxDbiQ3U0V1
PeptideAtlasiQ3U0V1
PRIDEiQ3U0V1

Protocols and materials databases

DNASUi16549
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007814; ENSMUSP00000007814; ENSMUSG00000007670
GeneIDi16549
KEGGimmu:16549
UCSCiuc008ddr.2 mouse

Organism-specific databases

CTDi8570
MGIiMGI:1336214 Khsrp

Phylogenomic databases

eggNOGiKOG1676 Eukaryota
ENOG410XZYE LUCA
GeneTreeiENSGT00730000110664
HOGENOMiHOG000231552
HOVERGENiHBG000625
InParanoidiQ3U0V1
KOiK13210
OMAiPAGQSDY
OrthoDBiEOG091G073X
TreeFamiTF313654

Enzyme and pathway databases

ReactomeiR-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA

Miscellaneous databases

PROiPR:Q3U0V1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007670 Expressed in 236 organ(s), highest expression level in heart
CleanExiMM_KHSRP
GenevisibleiQ3U0V1 MM

Family and domain databases

Gene3Di3.30.1370.10, 4 hits
InterProiView protein in InterPro
IPR015096 FUBP_C
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF09005 DUF1897, 2 hits
PF00013 KH_1, 4 hits
SMARTiView protein in SMART
SM00322 KH, 4 hits
SUPFAMiSSF54791 SSF54791, 4 hits
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50084 KH_TYPE_1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFUBP2_MOUSE
AccessioniPrimary (citable) accession number: Q3U0V1
Secondary accession number(s): E9QKH3, Q2VPQ6, Q6P2L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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