Khsrp

Functionⁱ

Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity).By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
mRNA 3'-UTR AU-rich region binding Source: UniProtKB
mRNA 3'-UTR binding Source: MGI
mRNA binding
Source: MGI
Inferred from direct assayⁱ
- 22844247

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

3'-UTR-mediated mRNA destabilization Source: UniProtKB
cellular response to cytokine stimulus Source: UniProtKB
miRNA metabolic process Source: UniProtKB
mRNA catabolic process
Source: MGI
Inferred from direct assayⁱ
- 22844247
mRNA processing Source: UniProtKB-KW
mRNA transport Source: UniProtKB-KW
negative regulation of low-density lipoprotein particle clearance Source: MGI
negative regulation of nitric oxide biosynthetic process Source: UniProtKB
positive regulation of mRNA catabolic process Source: UniProtKB
regulation of miRNA metabolic process
Source: MGI
Inferred from direct assayⁱ
- 22844247
regulation of mRNA stability Source: UniProtKB
regulation of transcription, DNA-templated Source: InterPro
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, RNA-binding
Biological process	mRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA

Reactomeⁱ

R-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Far upstream element-binding protein 2 Short name: FUSE-binding protein 2 Alternative name(s): KH type-splicing regulatory protein Short name: KSRP
Gene namesⁱ	Name:Khsrp Synonyms:Fubp2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1336214 Khsrp

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000298678	2 – 748	Far upstream element-binding protein 2Add BLAST		747

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	40	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	88	N6-acetyllysineCombined sources	1
Modified residueⁱ	101	PhosphothreonineBy similarity	1
Cross-linkⁱ	122	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	122	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	126	PhosphoserineBy similarity	1
Modified residueⁱ	130	PhosphoserineBy similarity	1
Modified residueⁱ	182	PhosphoserineCombined sources	1
Modified residueⁱ	185	PhosphoserineBy similarity	1
Modified residueⁱ	194	PhosphoserineBy similarity	1
Modified residueⁱ	275	PhosphoserineBy similarity	1
Modified residueⁱ	412	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	414	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	416	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	443	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	481	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q3U0V1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3U0V1
PaxDbⁱ	Q3U0V1
PeptideAtlas More...PeptideAtlasⁱ	Q3U0V1
PRIDEⁱ	Q3U0V1

PTM databases

iPTMnetⁱ	Q3U0V1
PhosphoSitePlusⁱ	Q3U0V1
SwissPalmⁱ	Q3U0V1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000007670 Expressed in 236 organ(s), highest expression level in heart
CleanExⁱ	MM_KHSRP
Genevisibleⁱ	Q3U0V1 MM

Interactionⁱ

Subunit structureⁱ

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN. Interacts with PQBP1.By similarity

Protein-protein interaction databases

BioGridⁱ	200927, 4 interactors
IntActⁱ	Q3U0V1, 5 interactors
STRINGⁱ	10090.ENSMUSP00000007814

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3U0V1
SMRⁱ	Q3U0V1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	145 – 209	KH 1PROSITE-ProRule annotationAdd BLAST	65
Domainⁱ	234 – 300	KH 2PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	323 – 387	KH 3PROSITE-ProRule annotationAdd BLAST	65
Domainⁱ	425 – 492	KH 4PROSITE-ProRule annotationAdd BLAST	68
Repeatⁱ	572 – 583	1Add BLAST	12
Repeatⁱ	618 – 629	2Add BLAST	12
Repeatⁱ	644 – 655	3Add BLAST	12
Repeatⁱ	674 – 685	4Add BLAST	12

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	572 – 685	4 X 12 AA imperfect repeatsAdd BLAST		114

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	7 – 68	Gly/Pro-richAdd BLAST	62
Compositional biasⁱ	69 – 497	Gly-richAdd BLAST	429
Compositional biasⁱ	499 – 613	Ala/Gly/Pro-richAdd BLAST	115

Sequence similaritiesⁱ

Belongs to the KHSRP family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1676 Eukaryota ENOG410XZYE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110664
HOGENOMⁱ	HOG000231552
HOVERGENⁱ	HBG000625
InParanoidⁱ	Q3U0V1
KEGG Orthology (KO) More...KOⁱ	K13210
OMAⁱ	PAGQSDY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G073X
TreeFamⁱ	TF313654

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 4 hits
InterProⁱ	View protein in InterPro IPR015096 FUBP_C IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09005 DUF1897, 2 hits PF00013 KH_1, 4 hits
SMARTⁱ	View protein in SMART SM00322 KH, 4 hits
SUPFAMⁱ	SSF54791 SSF54791, 4 hits
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit PS50084 KH_TYPE_1, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q3U0V1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDYNTGGPP PGPPPPAGGG GGAAGAGGGP PPGPPGAGDR GGGGPGGGGP 
        60         70         80         90        100
GGGGASGGPS QPPGGGGPGI RKDAFADAVQ RARQIAAKIG GDAATTVNNN 
       110        120        130        140        150
TPDFGFGGQK RQLEDGDQPD SKKLASQGDS IGSQLGPIHP PPRTSMTEEY 
       160        170        180        190        200
RVPDGMVGLI IGRGGEQINK IQQDSGCKVQ ISPDSGGLPE RSVSLTGAPE 
       210        220        230        240        250
SVQKAKMMLD DIVSRGRGGP PGQFHDNANG GQNGTVQEIM IPAGKAGLVI 
       260        270        280        290        300
GKGGETIKQL QERAGVKMIL IQDGSQNTNV DKPLRIIGDP YKVQQACEMV 
       310        320        330        340        350
MDILRERDQG GFGDRNEYGS RVGGGIDVPV PRHSVGVVIG RSGEMIKKIQ 
       360        370        380        390        400
NDAGVRIQFK QDDGTGPEKI AHIMGPPDRC EHAARIINDL LQSLRSGPPG 
       410        420        430        440        450
PPGAPGMPPG GRGRGRGQGN WGPPGGEMTF SIPTHKCGLV IGRGGENVKA 
       460        470        480        490        500
INQQTGAFVE ISRQLPPNGD PNFKLFVIRG SPQQIDHAKQ LIEEKIEGPL 
       510        520        530        540        550
CPVGPGPGGP GPAGPMGPFN PGPFNQGPPG APPHAGGPPP HQYPPQGWGN 
       560        570        580        590        600
TYPQWQPPAP HDPNKAAAAA TDPNAAWAAY YSHYYQQPPG PVPGPAPAPA 
       610        620        630        640        650
APPAQGEPPQ PPPTGQSDYT KAWEEYYKKI GQQPQQPGAP PQQDYTKAWE 
       660        670        680        690        700
EYYKKQAQVA TGGGPGAPPG SQPDYSAAWA EYYRQQAAYY GQTPGPGGPQ 
       710        720        730        740 
PPPTQQGQQQ ASGNCHPPPP PFSFQPPATV HPALVGSAGN PFPCGVCP

Length:748

Mass (Da):76,775

Last modified:July 27, 2011 - v2

Checksum:ⁱ0699217B3E1E54A9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	387	I → F in BAE33750 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK156541 mRNA Translation: BAE33750.1 CT571247 Genomic DNA No translation available. BC064454 mRNA Translation: AAH64454.1 BC108414 mRNA Translation: AAI08415.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50157.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034743.3, NM_010613.3
UniGeneⁱ	Mm.34296

Genome annotation databases

Ensemblⁱ	ENSMUST00000007814; ENSMUSP00000007814; ENSMUSG00000007670
GeneIDⁱ	16549
KEGGⁱ	mmu:16549
UCSC genome browser More...UCSCⁱ	uc008ddr.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3U0V1	KHSRP isoform 7 (Fragment)		PONAB		175	UniRef100_Q3U0V1
KHSRP isoform 8 (Fragment)		PANTR		175

Protein	Similar proteins		Species	Score	Length	Source
Q3U0V1	Far upstream element-binding protein 2	)	HUMAN		711	UniRef90_Q92945
Far upstream element-binding protein 2		RAT		721
Uncharacterized protein		CALJA		711
KHSRP isoform 1		PONAB		711
KHSRP isoform 2		PANTR		711
+109

Protein	Similar proteins		Species	Score	Length	Source
Q3U0V1	Far upstream element-binding protein 2	)	HUMAN		711	UniRef50_Q92945
Far upstream element-binding protein 2		RAT		721
Far upstream element-binding protein 2		CHICK		769
Uncharacterized protein		CALJA		711
KHSRP isoform 1		PONAB		711
+284

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK156541 mRNA Translation: BAE33750.1 CT571247 Genomic DNA No translation available. BC064454 mRNA Translation: AAH64454.1 BC108414 mRNA Translation: AAI08415.1
CCDSⁱ	CCDS50157.1
RefSeqⁱ	NP_034743.3, NM_010613.3
UniGeneⁱ	Mm.34296

3D structure databases

ProteinModelPortalⁱ	Q3U0V1
SMRⁱ	Q3U0V1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200927, 4 interactors
IntActⁱ	Q3U0V1, 5 interactors
STRINGⁱ	10090.ENSMUSP00000007814

PTM databases

iPTMnetⁱ	Q3U0V1
PhosphoSitePlusⁱ	Q3U0V1
SwissPalmⁱ	Q3U0V1

Proteomic databases

EPDⁱ	Q3U0V1
MaxQBⁱ	Q3U0V1
PaxDbⁱ	Q3U0V1
PeptideAtlasⁱ	Q3U0V1
PRIDEⁱ	Q3U0V1

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	16549
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000007814; ENSMUSP00000007814; ENSMUSG00000007670
GeneIDⁱ	16549
KEGGⁱ	mmu:16549
UCSCⁱ	uc008ddr.2 mouse

Organism-specific databases

CTDⁱ	8570
MGIⁱ	MGI:1336214 Khsrp

Phylogenomic databases

eggNOGⁱ	KOG1676 Eukaryota ENOG410XZYE LUCA
GeneTreeⁱ	ENSGT00730000110664
HOGENOMⁱ	HOG000231552
HOVERGENⁱ	HBG000625
InParanoidⁱ	Q3U0V1
KOⁱ	K13210
OMAⁱ	PAGQSDY
OrthoDBⁱ	EOG091G073X
TreeFamⁱ	TF313654

Enzyme and pathway databases

Reactomeⁱ	R-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA

Reactomeⁱ

R-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3U0V1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000007670 Expressed in 236 organ(s), highest expression level in heart
CleanExⁱ	MM_KHSRP
Genevisibleⁱ	Q3U0V1 MM

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 4 hits
InterProⁱ	View protein in InterPro IPR015096 FUBP_C IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf
Pfamⁱ	View protein in Pfam PF09005 DUF1897, 2 hits PF00013 KH_1, 4 hits
SMARTⁱ	View protein in SMART SM00322 KH, 4 hits
SUPFAMⁱ	SSF54791 SSF54791, 4 hits
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit PS50084 KH_TYPE_1, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUBP2_MOUSE
Accessionⁱ	Q3U0V1Primary (citable) accession number: Q3U0V1 Secondary accession number(s): E9QKH3, Q2VPQ6, Q6P2L2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3U0V1 (FUBP2_MOUSE)

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Far upstream element-binding protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ