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Protein

Trafficking protein particle complex subunit 9

Gene

Trappc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Biological processi

Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 9
Alternative name(s):
NIK- and IKBKB-binding protein
Gene namesi
Name:Trappc9
Synonyms:Kiaa1882, Nibp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1923760 Trappc9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415871 – 1148Trafficking protein particle complex subunit 9Add BLAST1148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei566PhosphoserineBy similarity1
Modified residuei953PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3U0M1
PaxDbiQ3U0M1
PeptideAtlasiQ3U0M1
PRIDEiQ3U0M1

PTM databases

iPTMnetiQ3U0M1
PhosphoSitePlusiQ3U0M1

Expressioni

Tissue specificityi

Expressed in neurons of the pyramidal layer of the cortex, in spinal cord motor neurons and white matter neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000047921 Expressed in 222 organ(s), highest expression level in brain
ExpressionAtlasiQ3U0M1 baseline and differential
GenevisibleiQ3U0M1 MM

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Directly interacts with IKBKB and MAP3K14.By similarity1 Publication

Protein-protein interaction databases

BioGridi218162, 2 interactors
IntActiQ3U0M1, 1 interactor
STRINGi10090.ENSMUSP00000087202

Structurei

3D structure databases

ProteinModelPortaliQ3U0M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIBP family.Curated

Phylogenomic databases

eggNOGiKOG1953 Eukaryota
ENOG410YEPC LUCA
GeneTreeiENSGT00390000006486
HOVERGENiHBG108595
InParanoidiQ3U0M1
KOiK20306
OMAiFLFTPIH
OrthoDBiEOG091G00SS
PhylomeDBiQ3U0M1
TreeFamiTF314341

Family and domain databases

InterProiView protein in InterPro
IPR013935 TRAPP_II_complex_Trs120
PANTHERiPTHR21512 PTHR21512, 1 hit
PfamiView protein in Pfam
PF08626 TRAPPC9-Trs120, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U0M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPDYMQCA EDHQTLLVVV QAVGIVSEEN FFRIYKRICS VSQLSVRDTQ
60 70 80 90 100
RALFIRYRHH YPPENNEWGD FQTHRKVVGL ITITDCFSPK DWPQTFEKFH
110 120 130 140 150
VQKEIYGSTL YDSRLFVFGL QGDVAEQPRP DVAFYPNYDD CDSVEKRIED
160 170 180 190 200
FIESLFIVLE SKRLDRATDK SGDKIPLLCV PFEKKDFVGL DTDSRHYKKR
210 220 230 240 250
CQGRMRKHVG DLCLQAGMLQ DALVHYHMSV ELLRSVNDFL WLGAALEGLC
260 270 280 290 300
SASVIYHYPG GTGGKTGARR LQGSSLPSEA ANRHRPGAQE VLIDPGALTT
310 320 330 340 350
NGINPDTSTE IGRAKNCLSP EDIIDKYKEA ISYYSKYKNA GVIELEACVK
360 370 380 390 400
AVRVLAIQKR GMEASEFLQN AVYINLRQLS EEEKIQRYSI LSELYELIGF
410 420 430 440 450
HRKSAFFKRV AAMQCVAPSI AEPGWRACYK LLLETLPGYS LSLDPKDFSK
460 470 480 490 500
GTHRGWAAVQ MRLLHELVYA SRRMGNPALS VRHLSFLLQT MLDFLSDQEK
510 520 530 540 550
KDVTQSLENY TAKCPGTMEP ITLPDGLTLP PVPFTKLPIV RCVKLLSLPT
560 570 580 590 600
SLRPHKVKSL LGQSMSTKSP FIYSPIIAHN RGEERNKKID FQWVQGDVCE
610 620 630 640 650
VQLMVYNPMP FELRVENMGL LTSGVEFESL PAALSLPAES GLYPVTLVGV
660 670 680 690 700
PQTTGMITVN GYHTTVFGVF SDCLLDNLPG LKTGGSTVEV IPALPRLQIS
710 720 730 740 750
TSLPRSARSL QPSAGDEIAT NVSVQLYNGE TQQLAVTLEN IGLEPLEQLE
760 770 780 790 800
VTSKLLTTKE KLYGDFLSWK LEETLAQFPL QPGKVATFTI NIKAKLDFSC
810 820 830 840 850
QENLLQDLSD DGISVSGFPL SSPFRQVVRP RVESRPTNPS EGSKTGDLGH
860 870 880 890 900
VKTLEAVLNF KYSGGPGHVE GYYRNLSLGL HVEVEPSVFF TRVSTLPATS
910 920 930 940 950
TRQCHLLLDV FNSTEHELTV CARNNSELVL HASECQRMAI QVDKFNFESV
960 970 980 990 1000
PESPGEKGHF ANLKQLEEER QEARGLEISS KLDIRWRIPS LKRSGEASVE
1010 1020 1030 1040 1050
GLLNQLILEH LQLAPLQWDV LVDGQPCDCE VAAACQVGDP VRLEVRLTNR
1060 1070 1080 1090 1100
SPRSVGPFAL TVVPFQDHQN GVHNYDLHDV ISFVGSSTFY LDTVQPSGQS
1110 1120 1130 1140
TCLGALLFLY TGDFFLNIRF HEDCKSKELP PSWVCLPSVH VRALGAQA
Length:1,148
Mass (Da):128,232
Last modified:June 10, 2008 - v2
Checksum:iFB3C68229B691327
GO
Isoform 2 (identifier: Q3U0M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.

Show »
Length:1,139
Mass (Da):127,309
Checksum:i88C881C315B97D4F
GO
Isoform 3 (identifier: Q3U0M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     189-194: GLDTDS → MLLGLK

Show »
Length:960
Mass (Da):106,289
Checksum:iEC755059DF2B0BB7
GO
Isoform 4 (identifier: Q3U0M1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.
     706-1148: Missing.

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):78,299
Checksum:i8083C09CB1BEB867
GO
Isoform 5 (identifier: Q3U0M1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-294: Missing.
     499-503: EKKDV → ETLAT
     504-1148: Missing.

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):56,240
Checksum:i2B040FEBFE4C1D3C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3T8E9Q3T8_MOUSE
Trafficking protein particle comple...
Trappc9
940Annotation score:
E9PZ41E9PZ41_MOUSE
Trafficking protein particle comple...
Trappc9
852Annotation score:

Sequence cautioni

The sequence BAB25242 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti773E → D in AAH70463 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0343511 – 188Missing in isoform 3. 2 PublicationsAdd BLAST188
Alternative sequenceiVSP_034352189 – 194GLDTDS → MLLGLK in isoform 3. 2 Publications6
Alternative sequenceiVSP_034353286 – 294Missing in isoform 2, isoform 4 and isoform 5. 2 Publications9
Alternative sequenceiVSP_034354499 – 503EKKDV → ETLAT in isoform 5. 1 Publication5
Alternative sequenceiVSP_034355504 – 1148Missing in isoform 5. 1 PublicationAdd BLAST645
Alternative sequenceiVSP_034356706 – 1148Missing in isoform 4. 1 PublicationAdd BLAST443

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630620 mRNA Translation: AAV31909.1
AK007766 mRNA Translation: BAB25242.1 Different initiation.
AK031788 mRNA Translation: BAC27550.1
AK138682 mRNA Translation: BAE23746.1
AK156739 mRNA Translation: BAE33831.1
BC034590 mRNA Translation: AAH34590.1
BC070463 mRNA Translation: AAH70463.1
AK173287 mRNA Translation: BAD32565.1
CCDSiCCDS37095.1 [Q3U0M1-2]
CCDS37096.1 [Q3U0M1-3]
RefSeqiNP_001158113.1, NM_001164641.1
NP_001158114.1, NM_001164642.1
NP_001158115.1, NM_001164643.1 [Q3U0M1-5]
NP_083916.1, NM_029640.2 [Q3U0M1-3]
NP_850993.2, NM_180662.2 [Q3U0M1-2]
XP_006521590.1, XM_006521527.3 [Q3U0M1-1]
UniGeneiMm.158902

Genome annotation databases

EnsembliENSMUST00000023276; ENSMUSP00000023276; ENSMUSG00000047921 [Q3U0M1-3]
ENSMUST00000089770; ENSMUSP00000087202; ENSMUSG00000047921 [Q3U0M1-2]
ENSMUST00000228960; ENSMUSP00000155105; ENSMUSG00000047921 [Q3U0M1-5]
GeneIDi76510
KEGGimmu:76510
UCSCiuc007wbl.2 mouse [Q3U0M1-3]
uc007wbm.1 mouse [Q3U0M1-2]
uc007wbp.1 mouse [Q3U0M1-4]
uc011ztt.1 mouse [Q3U0M1-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630620 mRNA Translation: AAV31909.1
AK007766 mRNA Translation: BAB25242.1 Different initiation.
AK031788 mRNA Translation: BAC27550.1
AK138682 mRNA Translation: BAE23746.1
AK156739 mRNA Translation: BAE33831.1
BC034590 mRNA Translation: AAH34590.1
BC070463 mRNA Translation: AAH70463.1
AK173287 mRNA Translation: BAD32565.1
CCDSiCCDS37095.1 [Q3U0M1-2]
CCDS37096.1 [Q3U0M1-3]
RefSeqiNP_001158113.1, NM_001164641.1
NP_001158114.1, NM_001164642.1
NP_001158115.1, NM_001164643.1 [Q3U0M1-5]
NP_083916.1, NM_029640.2 [Q3U0M1-3]
NP_850993.2, NM_180662.2 [Q3U0M1-2]
XP_006521590.1, XM_006521527.3 [Q3U0M1-1]
UniGeneiMm.158902

3D structure databases

ProteinModelPortaliQ3U0M1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218162, 2 interactors
IntActiQ3U0M1, 1 interactor
STRINGi10090.ENSMUSP00000087202

PTM databases

iPTMnetiQ3U0M1
PhosphoSitePlusiQ3U0M1

Proteomic databases

MaxQBiQ3U0M1
PaxDbiQ3U0M1
PeptideAtlasiQ3U0M1
PRIDEiQ3U0M1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023276; ENSMUSP00000023276; ENSMUSG00000047921 [Q3U0M1-3]
ENSMUST00000089770; ENSMUSP00000087202; ENSMUSG00000047921 [Q3U0M1-2]
ENSMUST00000228960; ENSMUSP00000155105; ENSMUSG00000047921 [Q3U0M1-5]
GeneIDi76510
KEGGimmu:76510
UCSCiuc007wbl.2 mouse [Q3U0M1-3]
uc007wbm.1 mouse [Q3U0M1-2]
uc007wbp.1 mouse [Q3U0M1-4]
uc011ztt.1 mouse [Q3U0M1-5]

Organism-specific databases

CTDi83696
MGIiMGI:1923760 Trappc9
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1953 Eukaryota
ENOG410YEPC LUCA
GeneTreeiENSGT00390000006486
HOVERGENiHBG108595
InParanoidiQ3U0M1
KOiK20306
OMAiFLFTPIH
OrthoDBiEOG091G00SS
PhylomeDBiQ3U0M1
TreeFamiTF314341

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTrappc9 mouse
PROiPR:Q3U0M1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047921 Expressed in 222 organ(s), highest expression level in brain
ExpressionAtlasiQ3U0M1 baseline and differential
GenevisibleiQ3U0M1 MM

Family and domain databases

InterProiView protein in InterPro
IPR013935 TRAPP_II_complex_Trs120
PANTHERiPTHR21512 PTHR21512, 1 hit
PfamiView protein in Pfam
PF08626 TRAPPC9-Trs120, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC9_MOUSE
AccessioniPrimary (citable) accession number: Q3U0M1
Secondary accession number(s): Q3UU81
, Q69Z79, Q6NS50, Q8CD01, Q8CFV8, Q9D8R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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