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Protein

Solute carrier family 25 member 33

Gene

Slc25a33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 33
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917806 Slc25a33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei49 – 65Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917861 – 320Solute carrier family 25 member 33Add BLAST320

Proteomic databases

MaxQBiQ3TZX3
PaxDbiQ3TZX3
PeptideAtlasiQ3TZX3
PRIDEiQ3TZX3

PTM databases

PhosphoSitePlusiQ3TZX3
SwissPalmiQ3TZX3

Expressioni

Gene expression databases

BgeeiENSMUSG00000028982
CleanExiMM_SLC25A33
GenevisibleiQ3TZX3 MM

Interactioni

Protein-protein interaction databases

BioGridi214130, 1 interactor
STRINGi10090.ENSMUSP00000101311

Structurei

3D structure databases

ProteinModelPortaliQ3TZX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 118Solcar 1Add BLAST110
Repeati126 – 213Solcar 2Add BLAST88
Repeati231 – 315Solcar 3Add BLAST85

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757 Eukaryota
ENOG410XS20 LUCA
GeneTreeiENSGT00550000074670
HOGENOMiHOG000188210
HOVERGENiHBG059891
InParanoidiQ3TZX3
KOiK15116
OMAiTHVAVQF
OrthoDBiEOG091G0BCW
PhylomeDBiQ3TZX3
TreeFamiTF314220

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q3TZX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTQQKEN TLLHLFAGGC GGTVGAIFTC PLEVIKTRLQ SSRLALRTVY
60 70 80 90 100
YPQVHLGTIS GAGMVRPTSV TPGLLQVLKS ILEKEGPKSL FRGLGPNLVG
110 120 130 140 150
VAPSRAVYFA CYSKAKEQFN GIFVPNSNTV HILSAGSAAF VTNTLMNPIW
160 170 180 190 200
MVKTRMQLER KVRGCKQMNT LQCARRVYQT EGVRGFYRGL TASYAGISET
210 220 230 240 250
IICFAIYESL KKCLKDAPIV SSTDGAEKSS SGFFGLMAAA AVSKGCASCI
260 270 280 290 300
AYPHEVIRTR LREEGSKYRS FVQTARLVFR EEGYLAFYRG LFAQLIRQIP
310 320
NTAIVLSTYE FIVYLLGERA
Length:320
Mass (Da):35,064
Last modified:October 11, 2005 - v1
Checksum:i39D2EB15037D2AEC
GO

Sequence cautioni

The sequence BAB30846 differs from that shown. Reason: Frameshift at position 260.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31P → H in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti122I → V in AAH11293 (PubMed:15489334).Curated1
Sequence conflicti129T → N in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti154T → K in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti189G → V in BAB30846 (PubMed:16141072).Curated1
Sequence conflicti293A → T in BAB30846 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017628 mRNA Translation: BAB30846.1 Frameshift.
AK157423 mRNA Translation: BAE34084.1
AL626808 Genomic DNA No translation available.
BC011293 mRNA Translation: AAH11293.1
CCDSiCCDS38976.1
RefSeqiNP_081736.2, NM_027460.2
UniGeneiMm.41877

Genome annotation databases

EnsembliENSMUST00000105686; ENSMUSP00000101311; ENSMUSG00000028982
GeneIDi70556
KEGGimmu:70556
UCSCiuc008vxe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS2533_MOUSE
AccessioniPrimary (citable) accession number: Q3TZX3
Secondary accession number(s): Q921P8, Q9CYJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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