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Protein

RUN and FYVE domain-containing protein 4

Gene

Rufy4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri428 – 558FYVE-typePROSITE-ProRule annotationAdd BLAST131

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RUN and FYVE domain-containing protein 4
Gene namesi
Name:Rufy4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3588214 Rufy4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846721 – 563RUN and FYVE domain-containing protein 4Add BLAST563

Proteomic databases

PaxDbiQ3TYX8
PRIDEiQ3TYX8

PTM databases

iPTMnetiQ3TYX8
PhosphoSitePlusiQ3TYX8

Expressioni

Gene expression databases

BgeeiENSMUSG00000061815
CleanExiMM_RUFY4

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115873

Structurei

3D structure databases

ProteinModelPortaliQ3TYX8
SMRiQ3TYX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 166RUNPROSITE-ProRule annotationAdd BLAST134

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri428 – 558FYVE-typePROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
ENOG410XPJK LUCA
GeneTreeiENSGT00910000144126
HOGENOMiHOG000154226
HOVERGENiHBG108427
InParanoidiQ3TYX8
OMAiPMFSESR
OrthoDBiEOG091G00LS
TreeFamiTF341788

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TYX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANNGTILKI SRSLKNAVSA ILQGYGDGQE PVTETSAELH RLCGCLELLL
60 70 80 90 100
QFDQKEQRSF LGARKDYWDF LFTALRRHRG YTEQMSFICS QDKLKTSLGK
110 120 130 140 150
GRAFIRLCLA RGQLAESMQL CLLNPQLTRE WYGPRSPLLC AELQEDILDS
160 170 180 190 200
LYALNGVAFN LDLQRPDLDE AWPMFSESRC SSPSRTGKRR PGKPKGFPEE
210 220 230 240 250
VRCSRGEQLQ EPDTGGTSCL QDATREDRTP DLCKPLQPSH LPTFLEEKRE
260 270 280 290 300
DSRSLSCPQS TWETEREGFQ LDQKDGGPKP RKFLENSTAS IQQQRSRAKD
310 320 330 340 350
VKMQLTGRKV EGKGSLSGTE DQRTTEGIQK RAADWDLGQG LMAPGLQGRE
360 370 380 390 400
DAELGYRCEW NQPDVLRQSW VLGTKKSSPT EKPQEWTGVT SGTMQEDGSE
410 420 430 440 450
VPLQQEVIKD PGYGLQLAKE QAQCQEQLRA QEAELQALQE QLSRCQKERA
460 470 480 490 500
LLQVKLEQKQ QEAERRDAMY QTELEGQRDL VQAMKRRVLE LIHEKDLQWQ
510 520 530 540 550
RLQQLSTVAP GHCIGCNKVF RRLSRRYPCR LCGGLVCHAC SVDYKKRERC
560
CPTCAQQEEI QDT
Length:563
Mass (Da):64,036
Last modified:July 27, 2011 - v3
Checksum:i2D2F11ACE0F80F78
GO
Isoform 2 (identifier: Q3TYX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:479
Mass (Da):54,449
Checksum:iF2934176C284634F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34E → D in AAI50908 (PubMed:15489334).Curated1
Sequence conflicti34E → D in AAI50911 (PubMed:15489334).Curated1
Sequence conflicti141A → P in AAI50908 (PubMed:15489334).Curated1
Sequence conflicti141A → P in AAI50911 (PubMed:15489334).Curated1
Sequence conflicti141A → P in BAE34432 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0358171 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK158260 mRNA Translation: BAE34432.1
AC117757 Genomic DNA No translation available.
BC150907 mRNA Translation: AAI50908.1
BC150910 mRNA Translation: AAI50911.1
CCDSiCCDS15039.1 [Q3TYX8-2]
CCDS48289.1 [Q3TYX8-1]
RefSeqiNP_001029232.2, NM_001034060.3 [Q3TYX8-2]
NP_001164112.1, NM_001170641.1 [Q3TYX8-1]
UniGeneiMm.240447

Genome annotation databases

EnsembliENSMUST00000080167; ENSMUSP00000079062; ENSMUSG00000061815 [Q3TYX8-2]
ENSMUST00000127134; ENSMUSP00000115873; ENSMUSG00000061815 [Q3TYX8-1]
GeneIDi435626
KEGGimmu:435626
UCSCiuc007blk.2 mouse [Q3TYX8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRUFY4_MOUSE
AccessioniPrimary (citable) accession number: Q3TYX8
Secondary accession number(s): B2RX43, D3YY30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 27, 2011
Last modified: February 28, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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