We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q3TYS2 (CYBC1_MOUSE)
Protein
Cytochrome b-245 chaperone 1
Gene
Cybc1
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity).
Controls the phagocyte respiratory burst and is essential for innate immunity (PubMed:28351984).
By similarity1 PublicationGO - Biological processi
- innate immune response Source: UniProtKB
- respiratory burst after phagocytosis Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Biological process | Immunity, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-245 chaperone 1CuratedAlternative name(s): Essential for reactive oxygen species protein1 Publication Short name: Eros1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384959, Cybc1 |
VEuPathDBi | HostDB:ENSMUSG00000039294 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 42 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Mutants are highly susceptible to Salmonella and Listeria infection and are impaired in their ability to control replication of either pathogen (PubMed:28351984). Mutant neutrophiles have a highly impaired superoxide burst (PubMed:28351984). Mice are very susceptible to Listeria monocytogenes and die within 5 days of infection, fail to form neutrophil extracellular traps but are resistant to melanoma metastasis (PubMed:28351984).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281419 | 1 – 187 | Cytochrome b-245 chaperone 1Add BLAST | 187 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 168 | PhosphoserineBy similarity | 1 | |
Modified residuei | 170 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q3TYS2 |
MaxQBi | Q3TYS2 |
PaxDbi | Q3TYS2 |
PeptideAtlasi | Q3TYS2 |
PRIDEi | Q3TYS2 |
PTM databases
iPTMneti | Q3TYS2 |
PhosphoSitePlusi | Q3TYS2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039294, Expressed in spleen and 277 other tissues |
ExpressionAtlasi | Q3TYS2, baseline and differential |
Genevisiblei | Q3TYS2, MM |
Interactioni
Subunit structurei
Interacts with CYBB; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 229904, 2 interactors |
IntActi | Q3TYS2, 1 interactor |
STRINGi | 10090.ENSMUSP00000042277 |
Miscellaneous databases
RNActi | Q3TYS2, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 167 – 187 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the CYBC1 family.
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S06T, Eukaryota |
GeneTreei | ENSGT00390000004691 |
InParanoidi | Q3TYS2 |
OMAi | IRSWSLC |
OrthoDBi | 1293240at2759 |
PhylomeDBi | Q3TYS2 |
TreeFami | TF332389 |
Family and domain databases
InterProi | View protein in InterPro IPR027846, Cybc1 |
PANTHERi | PTHR31837, PTHR31837, 1 hit |
Pfami | View protein in Pfam PF15169, Cybc1_Eros, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q3TYS2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYMQVETRTS TRLHLKRAPG IRSWSLLVGI LSTGLAAAYY SGDSLGWKLF
60 70 80 90 100
YVTGCLFVAV QNLEDWEEAI FNKNTGKVIL KTFSLYKKLL TLLRAGHDQV
110 120 130 140 150
VVLLKDIQDV NVEEEKVRYF GKGYMVVLRF ATGFSHPLTQ SAVMGRRSDV
160 170 180
EAIAKLITSF LELHRLESPS ERSQSSDSEP DGPGGQS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q3W5 | E9Q3W5_MOUSE | Essential for reactive oxygen speci... | Cybc1 | 116 | Annotation score: | ||
X1WI15 | X1WI15_MOUSE | Essential for reactive oxygen speci... | Cybc1 | 131 | Annotation score: | ||
A0A0A0MQK0 | A0A0A0MQK0_MOUSE | Essential for reactive oxygen speci... | Cybc1 | 150 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 111 | N → S in BAE34490 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK145884 mRNA Translation: BAE26724.1 AK158402 mRNA Translation: BAE34490.1 AK159453 mRNA Translation: BAE35096.1 AK168104 mRNA Translation: BAE40075.1 AK170767 mRNA Translation: BAE42017.1 AL808021 Genomic DNA No translation available. BC017643 mRNA Translation: AAH17643.1 BC026616 mRNA Translation: AAH26616.1 BC027406 mRNA Translation: AAH27406.1 |
CCDSi | CCDS25771.1 |
RefSeqi | NP_001239477.1, NM_001252548.1 NP_001239478.1, NM_001252549.1 NP_001239479.1, NM_001252550.1 NP_001241664.1, NM_001254735.1 NP_659081.1, NM_144832.2 |
Genome annotation databases
Ensembli | ENSMUST00000038709; ENSMUSP00000042277; ENSMUSG00000039294 ENSMUST00000106115; ENSMUSP00000101721; ENSMUSG00000039294 |
GeneIDi | 217370 |
KEGGi | mmu:217370 |
UCSCi | uc007mvn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK145884 mRNA Translation: BAE26724.1 AK158402 mRNA Translation: BAE34490.1 AK159453 mRNA Translation: BAE35096.1 AK168104 mRNA Translation: BAE40075.1 AK170767 mRNA Translation: BAE42017.1 AL808021 Genomic DNA No translation available. BC017643 mRNA Translation: AAH17643.1 BC026616 mRNA Translation: AAH26616.1 BC027406 mRNA Translation: AAH27406.1 |
CCDSi | CCDS25771.1 |
RefSeqi | NP_001239477.1, NM_001252548.1 NP_001239478.1, NM_001252549.1 NP_001239479.1, NM_001252550.1 NP_001241664.1, NM_001254735.1 NP_659081.1, NM_144832.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 229904, 2 interactors |
IntActi | Q3TYS2, 1 interactor |
STRINGi | 10090.ENSMUSP00000042277 |
PTM databases
iPTMneti | Q3TYS2 |
PhosphoSitePlusi | Q3TYS2 |
Proteomic databases
EPDi | Q3TYS2 |
MaxQBi | Q3TYS2 |
PaxDbi | Q3TYS2 |
PeptideAtlasi | Q3TYS2 |
PRIDEi | Q3TYS2 |
Protocols and materials databases
Antibodypediai | 53358, 128 antibodies from 13 providers |
DNASUi | 217370 |
Genome annotation databases
Ensembli | ENSMUST00000038709; ENSMUSP00000042277; ENSMUSG00000039294 ENSMUST00000106115; ENSMUSP00000101721; ENSMUSG00000039294 |
GeneIDi | 217370 |
KEGGi | mmu:217370 |
UCSCi | uc007mvn.2, mouse |
Organism-specific databases
CTDi | 79415 |
MGIi | MGI:2384959, Cybc1 |
VEuPathDBi | HostDB:ENSMUSG00000039294 |
Phylogenomic databases
eggNOGi | ENOG502S06T, Eukaryota |
GeneTreei | ENSGT00390000004691 |
InParanoidi | Q3TYS2 |
OMAi | IRSWSLC |
OrthoDBi | 1293240at2759 |
PhylomeDBi | Q3TYS2 |
TreeFami | TF332389 |
Miscellaneous databases
BioGRID-ORCSi | 217370, 3 hits in 64 CRISPR screens |
ChiTaRSi | Cybc1, mouse |
PROi | PR:Q3TYS2 |
RNActi | Q3TYS2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039294, Expressed in spleen and 277 other tissues |
ExpressionAtlasi | Q3TYS2, baseline and differential |
Genevisiblei | Q3TYS2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027846, Cybc1 |
PANTHERi | PTHR31837, PTHR31837, 1 hit |
Pfami | View protein in Pfam PF15169, Cybc1_Eros, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CYBC1_MOUSE | |
Accessioni | Q3TYS2Primary (citable) accession number: Q3TYS2 Secondary accession number(s): A2AN24, A2AN25, Q8VD13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families