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Entry version 126 (16 Oct 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Aldehyde oxidase 4

Gene

Aox4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles.1 Publication

Miscellaneous

AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.8 µM for all-trans-retinal (at 37 degrees Celsius and pH 7.4)1 Publication
  1. Vmax=0.06 µmol/min/mg enzyme with all-trans-retinal as substrate (at 37 degrees Celsius and pH 7.4)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi52Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi55Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi77Iron-sulfur 1 (2Fe-2S)By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei116MolybdopterinBy similarity1
Metal bindingi117Iron-sulfur 2 (2Fe-2S)By similarity1
Metal bindingi120Iron-sulfur 2 (2Fe-2S)By similarity1
Metal bindingi152Iron-sulfur 2 (2Fe-2S)By similarity1
Metal bindingi154Iron-sulfur 2 (2Fe-2S)By similarity1
Binding sitei154MolybdopterinBy similarity1
Binding sitei346FAD; via amide nitrogenBy similarity1
Binding sitei355FADBy similarity1
Binding sitei359FADBy similarity1
Binding sitei368FADBy similarity1
Binding sitei413FAD; via amide nitrogenBy similarity1
Binding sitei1045Molybdopterin; via amide nitrogenBy similarity1
Binding sitei1201MolybdopterinBy similarity1
Binding sitei1265Molybdopterin; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1267Proton acceptor; for azaheterocycle hydroxylase activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi265 – 272FADBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldehyde oxidase 4 (EC:1.2.3.11 Publication)
Alternative name(s):
Aldehyde oxidase homolog 2
Azaheterocycle hydroxylase 4 (EC:1.17.3.-)
Retinal oxidase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aox4
Synonyms:Aoh2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919122 Aox4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable, fertile and born at the expected Mendelian rate. However, they show a deficiency of retinoic acid synthesis in both the Harderian gland and skin. The Harderian gland's transcriptome of knockout mice demonstrates overall down-regulation of direct retinoid-dependent genes as well as perturbations in pathways controlling lipid homeostasis and cellular secretion, particularly in sexually immature animals. The skin is characterized by thickening of the epidermis in basal conditions and after UVB light exposure.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004252501 – 1336Aldehyde oxidase 4Add BLAST1336

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TYQ9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q3TYQ9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q3TYQ9

PRoteomics IDEntifications database

More...
PRIDEi
Q3TYQ9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TYQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TYQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in Harderian glands and sebaceous glands with detectable levels in the epidermis and other keratinized epithelia (at protein level). Detected in testis. The expression is 3 times greater in females than in males.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by testosterone in Harderian glands. In skin, induced by UVB light.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038242 Expressed in 66 organ(s), highest expression level in skin epidermis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TYQ9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048929

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3TYQ9

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 952Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST88
Domaini237 – 423FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni804 – 805Molybdopterin bindingBy similarity2
Regioni1086 – 1089Molybdopterin bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0430 Eukaryota
COG4630 LUCA
COG4631 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183114

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q3TYQ9

KEGG Orthology (KO)

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KOi
K00157

Identification of Orthologs from Complete Genome Data

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OMAi
INMYKRT

Database of Orthologous Groups

More...
OrthoDBi
48717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TYQ9

TreeFam database of animal gene trees

More...
TreeFami
TF353036

Family and domain databases

Conserved Domains Database

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CDDi
cd00207 fer2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR016208 Ald_Oxase/xanthine_DH
IPR014313 Aldehyde_oxidase
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR005107 CO_DH_flav_C
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_PCMH
IPR036318 FAD-bd_PCMH-like_sf
IPR002346 Mopterin_DH_FAD-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
PF03450 CO_deh_flav_C, 1 hit
PF00941 FAD_binding_5, 1 hit
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000127 Xanthine_DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SM01092 CO_deh_flav_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
SSF54665 SSF54665, 1 hit
SSF55447 SSF55447, 1 hit
SSF56003 SSF56003, 1 hit
SSF56176 SSF56176, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02969 mam_aldehyde_ox, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS51387 FAD_PCMH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3TYQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSVSESDEL IFFVNGKKVI EKNPDPEKNL LFYTRKVLNL TGTKYSCGTG
60 70 80 90 100
GCGACTVMVS RYNPKTRKIH HYPATACLVP ICWLHGAAIT TVEGVGSIKK
110 120 130 140 150
RVHPVQERLA KCHGTQCGFC SPGMVMSIYT LLRNHPEPTP DQITEALGGN
160 170 180 190 200
LCRCTGYRPI VESGKTFSQK STVCQMKGSG KCCMDPDEKC LESREKKMCT
210 220 230 240 250
KLYNEDEFQP FDPSQEPIFP PELIRMAEDP NKRRLTFQGK RTTWIIPVTL
260 270 280 290 300
NDLLELKASY PEAPLVMGNT TVGPGIKFND EFYPVFISPL GVPELNLMDT
310 320 330 340 350
TNNGVTIGAG YSLAQLKDTL DFLVSEQPKE KTKTFHALQK HLRTLAGPQI
360 370 380 390 400
RNMATLGGHT ASRPNFSDLN PILAAGNATI NVVSREGKDR QLPLNGPFLE
410 420 430 440 450
KLPEADLKPE EVILSIFIPY TAQWQFVSGL RLAQRQENAF AIVNAGMSVE
460 470 480 490 500
FEEGTNTIKD LKMFFGSVAP TVVSASQTCK QLIGRQWDDQ MLSDACQLVL
510 520 530 540 550
QEIRIPPDAE GGMVEYRRTL IISLLFKFYL KVQRWLNEMD PQKFPDIPGK
560 570 580 590 600
FVSALDDFPI ETPQGIQMFQ CVDPKQPQKD PVGHPIMHQS GIKHATGEAI
610 620 630 640 650
FIDDMPPIDQ ELCLAVVTST RAHAKITSLD VSEALACPGV VDVITAEDVP
660 670 680 690 700
GENDHNGEIL YAQSEVICVG QIICTVAADT YIHAKEAAKR VKIAYDDIEP
710 720 730 740 750
TIITIEEALE HNSFLSPEKK IEQGNVDYAF KHVDQIVEGE IHVEGQEHFY
760 770 780 790 800
METQTILAIP QTEDKEMVLH LGTQFPTHVQ EFVSAALNVP RSRIACHMKR
810 820 830 840 850
AGGAFGGKVT KPALLGAVCA VAANKTGRPI RFILERSDDM LITAGRHPLL
860 870 880 890 900
GKYKIGFMNN GEIRAADVEY YTNGGCTPDE SELVIEFVVL KSENTYHIPN
910 920 930 940 950
FRCRGRACKT NLPSNTAFRG FGFPQATVVV EAYIAAVASK CNLLPEEVRE
960 970 980 990 1000
INMYKKTSKT AYKQTFNPEP LRRCWKECLE KSSFFARKKA AEEFNGNNYW
1010 1020 1030 1040 1050
KKRGLAVVPM KFSVAVPIAF YNQAAALVHI FLDGSVLLTH GGCELGQGLH
1060 1070 1080 1090 1100
TKMIQVASRE LNVPKSYVHF SETSTTTVPN SAFTAGSMGA DINGKAVQNA
1110 1120 1130 1140 1150
CQILMDRLRP IIRKNPKGKW EEWIKMAFEE SISLSATGYF KGYQTNMDWK
1160 1170 1180 1190 1200
KEEGDPYPYY VYGAACSEVE VDCLTGAHKL LRTDIFVDAA FSINPALDIG
1210 1220 1230 1240 1250
QVEGAFIQGM GFYTTEELKY SPKGVLYSRG PEDYKIPTIT EIPEEFYVTL
1260 1270 1280 1290 1300
VHSRNPIAIY SSKGLGEAGM FLGSSVLFAI YDAVTTARKE RGLSDIFPLN
1310 1320 1330
SPATPEVIRM ACTDQFTEMI PRDDPSTFTP WSIHVS
Length:1,336
Mass (Da):148,279
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF12D7DA84A31A717
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti386Missing in AAL38126 (PubMed:11562361).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF321814
, AF321780, AF321781, AF321782, AF321783, AF321784, AF321785, AF321786, AF321787, AF321788, AF321789, AF321790, AF321791, AF321792, AF321793, AF321794, AF321795, AF321796, AF321797, AF321798, AF321799, AF321800, AF321801, AF321802, AF321803, AF321804, AF321805, AF321806, AF321807, AF321808, AF321809, AF321810, AF321811, AF321812, AF321813 Genomic DNA Translation: AAL38126.1
AK158427 mRNA Translation: BAE34503.1
AC025116 Genomic DNA No translation available.
BC117975 mRNA Translation: AAI17976.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14970.1

NCBI Reference Sequences

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RefSeqi
NP_076120.2, NM_023631.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040442; ENSMUSP00000048929; ENSMUSG00000038242

Database of genes from NCBI RefSeq genomes

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GeneIDi
71872

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:71872

UCSC genome browser

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UCSCi
uc007bbo.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321814
, AF321780, AF321781, AF321782, AF321783, AF321784, AF321785, AF321786, AF321787, AF321788, AF321789, AF321790, AF321791, AF321792, AF321793, AF321794, AF321795, AF321796, AF321797, AF321798, AF321799, AF321800, AF321801, AF321802, AF321803, AF321804, AF321805, AF321806, AF321807, AF321808, AF321809, AF321810, AF321811, AF321812, AF321813 Genomic DNA Translation: AAL38126.1
AK158427 mRNA Translation: BAE34503.1
AC025116 Genomic DNA No translation available.
BC117975 mRNA Translation: AAI17976.1
CCDSiCCDS14970.1
RefSeqiNP_076120.2, NM_023631.2

3D structure databases

SMRiQ3TYQ9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048929

PTM databases

iPTMnetiQ3TYQ9
PhosphoSitePlusiQ3TYQ9

Proteomic databases

jPOSTiQ3TYQ9
MaxQBiQ3TYQ9
PaxDbiQ3TYQ9
PRIDEiQ3TYQ9

Genome annotation databases

EnsembliENSMUST00000040442; ENSMUSP00000048929; ENSMUSG00000038242
GeneIDi71872
KEGGimmu:71872
UCSCiuc007bbo.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
71872
MGIiMGI:1919122 Aox4

Phylogenomic databases

eggNOGiKOG0430 Eukaryota
COG4630 LUCA
COG4631 LUCA
GeneTreeiENSGT00950000183114
InParanoidiQ3TYQ9
KOiK00157
OMAiINMYKRT
OrthoDBi48717at2759
PhylomeDBiQ3TYQ9
TreeFamiTF353036

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Aox4 mouse

Protein Ontology

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PROi
PR:Q3TYQ9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000038242 Expressed in 66 organ(s), highest expression level in skin epidermis
GenevisibleiQ3TYQ9 MM

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR016208 Ald_Oxase/xanthine_DH
IPR014313 Aldehyde_oxidase
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR005107 CO_DH_flav_C
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_PCMH
IPR036318 FAD-bd_PCMH-like_sf
IPR002346 Mopterin_DH_FAD-bd
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
PF03450 CO_deh_flav_C, 1 hit
PF00941 FAD_binding_5, 1 hit
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit
PIRSFiPIRSF000127 Xanthine_DH, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SM01092 CO_deh_flav_C, 1 hit
SUPFAMiSSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
SSF54665 SSF54665, 1 hit
SSF55447 SSF55447, 1 hit
SSF56003 SSF56003, 1 hit
SSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR02969 mam_aldehyde_ox, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS51387 FAD_PCMH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAOXD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TYQ9
Secondary accession number(s): Q8VI17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: October 11, 2005
Last modified: October 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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