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Protein

Arylsulfatase G

Gene

Arsg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44CalciumBy similarity1
Metal bindingi45CalciumBy similarity1
Active sitei84NucleophileBy similarity1
Metal bindingi84Calcium; via 3-oxoalanineBy similarity1
Binding sitei137SubstrateBy similarity1
Active sitei139By similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi302CalciumBy similarity1
Metal bindingi303CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660662 Glycosphingolipid metabolism
R-MMU-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase G (EC:3.1.6.-)
Short name:
ASG
Gene namesi
Name:Arsg
Synonyms:Kiaa1001
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921258 Arsg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000023866317 – 525Arylsulfatase GAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei843-oxoalanine (Cys)By similarity1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3TYD4
PaxDbiQ3TYD4
PeptideAtlasiQ3TYD4
PRIDEiQ3TYD4

PTM databases

PhosphoSitePlusiQ3TYD4

Expressioni

Gene expression databases

BgeeiENSMUSG00000020604 Expressed in 177 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_ARSG
GenevisibleiQ3TYD4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020928

Structurei

3D structure databases

ProteinModelPortaliQ3TYD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOVERGENiHBG004283
InParanoidiQ3TYD4
KOiK12381
OMAiKAFYITG
OrthoDBiEOG091G041Y
PhylomeDBiQ3TYD4

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3TYD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGWLFLKVLL VGMAFSGFFY PLVDFSISGK TRAPQPNIVI ILADDMGWGD
60 70 80 90 100
LGANWAETKD TTNLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN
110 120 130 140 150
GVTHNFAVTS VGGLPVNETT LAEVLRQEGY VTAMIGKWHL GHHGSYHPNF
160 170 180 190 200
RGFDYYFGIP YSNDMGCTDA PGYNYPPCPA CPQRDGLWRN PGRDCYTDVA
210 220 230 240 250
LPLYENLNIV EQPVNLSGLA QKYAERAVEF IEQASTSGRP FLLYVGLAHM
260 270 280 290 300
HVPLSVTPPL AHPQRQSLYR ASLREMDSLV GQIKDKVDHV ARENTLLWFT
310 320 330 340 350
GDNGPWAQKC ELAGSVGPFF GLWQTHQGGS PTKQTTWEGG HRVPALAYWP
360 370 380 390 400
GRVPANVTST ALLSLLDIFP TVIALAGASL PPNRKFDGRD VSEVLFGKSQ
410 420 430 440 450
MGHRVLFHPN SGAAGEYGAL QTVRLNHYKA FYITGGAKAC DGSVGPEQHH
460 470 480 490 500
VAPLIFNLED AADEGMPLQK GSPEYQEVLQ QVTRALADVL QDIADDNSSR
510 520
ADYTQDPSVI PCCNPYQTTC RCQPV
Length:525
Mass (Da):57,434
Last modified:October 11, 2005 - v1
Checksum:iFA319206459D1B2B
GO
Isoform 2 (identifier: Q3TYD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
     324-327: QTHQ → MIKI

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):21,778
Checksum:i1C56A85519841355
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122A → V in AAH84731 (PubMed:15489334).Curated1
Sequence conflicti247L → Q in BAB31086 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186281 – 323Missing in isoform 2. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_018629324 – 327QTHQ → MIKI in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018132 mRNA Translation: BAB31086.1
AK158726 mRNA Translation: BAE34629.1
AL645791 Genomic DNA No translation available.
BC022158 mRNA Translation: AAH22158.1
BC039629 mRNA Translation: AAH39629.1
BC084731 mRNA Translation: AAH84731.1
AK173082 mRNA Translation: BAD32360.1
BN000747 mRNA Translation: CAI84993.1
CCDSiCCDS25581.1 [Q3TYD4-1]
CCDS48971.1 [Q3TYD4-2]
RefSeqiNP_001159649.1, NM_001166177.1 [Q3TYD4-2]
NP_082986.3, NM_028710.3 [Q3TYD4-1]
XP_006534411.1, XM_006534348.2 [Q3TYD4-1]
XP_006534412.1, XM_006534349.3 [Q3TYD4-1]
XP_006534413.1, XM_006534350.3 [Q3TYD4-1]
XP_017170289.1, XM_017314800.1 [Q3TYD4-1]
XP_017170290.1, XM_017314801.1 [Q3TYD4-1]
UniGeneiMm.482224

Genome annotation databases

EnsembliENSMUST00000020928; ENSMUSP00000020928; ENSMUSG00000020604 [Q3TYD4-1]
ENSMUST00000106696; ENSMUSP00000102307; ENSMUSG00000020604 [Q3TYD4-2]
ENSMUST00000106697; ENSMUSP00000102308; ENSMUSG00000020604 [Q3TYD4-1]
GeneIDi74008
KEGGimmu:74008
UCSCiuc007mcn.1 mouse [Q3TYD4-1]
uc007mcp.2 mouse [Q3TYD4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARSG_MOUSE
AccessioniPrimary (citable) accession number: Q3TYD4
Secondary accession number(s): B1AT67
, B1AT68, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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