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Entry version 98 (26 Feb 2020)
Sequence version 1 (11 Oct 2005)
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Protein

SH3 domain-containing protein

Gene

Sh3tc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sh3tc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2678949 Sh3tc1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TXV8 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 372SH3InterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 58DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 47PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFSQ Eukaryota
ENOG410Y8HX LUCA

Database of Orthologous Groups

More...
OrthoDBi
39940at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR042772 SH3TC1/SH3TC2
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR22647 PTHR22647, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018 SH3_1, 1 hit
PF13181 TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit
SM00028 TPR, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3TXV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSFREEEEE ATSEELFTMG RGPEEPRGSC SPEDQIQSVS MGLPTGQERT
60 70 80 90 100
GSAEAEATVR GDVAPPRIVV GLAAEPPPSQ MTVYPTDLTL QLLAVRRKSG
110 120 130 140 150
LRSPSLQQAL RSRLRLLEND SREVARVLGE LSARLLSIHS DQDRIVVTFK
160 170 180 190 200
TFEEIWKFST YHALGFTHHC LENLLVDQTF WLLSPSEEEE TAILMYVNKD
210 220 230 240 250
ALKQTHKNLL TQEGSIFVLC PDHRVRRTIG PKGAGKGPQT LRRASGVPLG
260 270 280 290 300
VAILETDSSS PTPNMSSNVE AAEAEPEPLT PFHQWTLRVP WDPIDESMSG
310 320 330 340 350
PGTPDAQLMR FGLASAIADF QGSDPEEMSF SVGDVIEILG AQVPGLPWCV
360 370 380 390 400
GRHMASGQVG FVRTGLVSMQ GPASDLESAI FLSEEERSFF RSEGHFSDED
410 420 430 440 450
ARRLLSRTSG TDVCTTCSLD WLEEAEGEQL EQREMSLPHL NPEPHGTLQM
460 470 480 490 500
VKNILEKCKA CPDHPEAPVS WSLGGVSRRA SSLDLEEPRF CLDPEDDWTD
510 520 530 540 550
PEPLDSLLQV LNAPGYGAHF RSLYDISLPW LSTALYGFDD EEELAERLAQ
560 570 580 590 600
ARGVAKKVDL SMALARLCLL LGRLCARKLK LSQARVYFEE ALGALEGSFG
610 620 630 640 650
DLSLVAAVYS SLTTVYLKQK NAEKCVQVAP KAAALLLGTP GHSCNADAEL
660 670 680 690 700
LKYALRRVIC GLSPQAEARA CFLLARHYTH LKQPEEALPY LERLLRLNRD
710 720 730 740 750
AGSPQASWPE DCYLLLADIY GRKCLPHLAL SCLRVSSLWT RCSLPGSLRS
760 770 780 790 800
VDLVLQNVPG PNSQRRAGHS LPSQIAYYLR QALASLAPGT GQALRGPLYA
810 820 830 840 850
SLAQLYSHHQ QYSQAIAFMS QAAEADTAAG VHPVVDRLVA LAWLHMLCGN
860 870 880 890 900
SLVAMDILKC ISDAAVANKD QECVMMNMVA MALKRMGRTR QAAEGYFRAL
910 920 930 940 950
HMAYAQGHLQ SQAVVLANFG ALCLQAGARS LAQHYLREAV GLFSQVPSGV
960 970 980 990 1000
CGRDFTQVLL WLGQLCTRRA LPQQAKCYYE WAFLVAVETD HLESQLQAVQ
1010 1020 1030 1040 1050
KLCLFYSKVM PNEVRCVIYH EFQLALARKT ANKVLEGQLL EAISQLYLSL
1060 1070 1080 1090 1100
GTERAYKSAL DYTKRSLGIF IDLQQKEKEA RAWLQAGKIY YILRQNELVD
1110 1120 1130 1140 1150
LYIQVAQNAA LYTGDPKLGL ELFEAAGDIF FNGTWEREKA VSFYRDRALP
1160 1170 1180 1190 1200
LAVTVGDQEV ELRLCNKLVA LLSALEAPQE GLEFAHEALA LSITLGDRLN
1210 1220 1230 1240 1250
ERVAYHRLAT LHHRLGHGEL AEHFFLKALS LCSSPLEFDE ETLYYVKVYL
1260 1270 1280 1290 1300
VLGDIIFYDL KDPFDAAGYY QLALAAAVDL GHKKAQLKIY TRLATIYHHF
1310 1320 1330 1340
LVDREMSLFF YQKARTFASE LNLRRTNLVP QRFCGRAPWL APGHPS
Length:1,346
Mass (Da):149,441
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82A1B0D784653AE8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK159089 mRNA Translation: BAE34807.1

NCBI Reference Sequences

More...
RefSeqi
NP_919325.2, NM_194344.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231147

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159089 mRNA Translation: BAE34807.1
RefSeqiNP_919325.2, NM_194344.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi231147

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54436
MGIiMGI:2678949 Sh3tc1

Phylogenomic databases

eggNOGiENOG410IFSQ Eukaryota
ENOG410Y8HX LUCA
OrthoDBi39940at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sh3tc1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ3TXV8 MM

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR042772 SH3TC1/SH3TC2
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR22647 PTHR22647, 1 hit
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3TXV8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TXV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 26, 2020
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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