UniProtKB - Q3TXU4 (Q3TXU4_MOUSE)
Protein
Submitted name:
Uncharacterized protein
Gene
Apoe
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: Ensembl
- antioxidant activity Source: Ensembl
- heparan sulfate proteoglycan binding Source: Ensembl
- heparin binding Source: Ensembl
- lipid transporter activity Source: Ensembl
- low-density lipoprotein particle receptor binding Source: Ensembl
- metal chelating activity Source: Ensembl
- phosphatidylcholine-sterol O-acyltransferase activator activity Source: Ensembl
- phospholipid binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- tau protein binding Source: Ensembl
- very-low-density lipoprotein particle receptor binding Source: Ensembl
GO - Biological processi
- AMPA glutamate receptor clustering Source: Ensembl
- amyloid precursor protein metabolic process Source: Ensembl
- cGMP-mediated signaling Source: Ensembl
- cholesterol efflux Source: Ensembl
- cholesterol homeostasis Source: Ensembl
- cholesterol metabolic process Source: Ensembl
- chylomicron remnant clearance Source: Ensembl
- fatty acid homeostasis Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Ensembl
- high-density lipoprotein particle assembly Source: Ensembl
- high-density lipoprotein particle clearance Source: Ensembl
- high-density lipoprotein particle remodeling Source: Ensembl
- intermediate-density lipoprotein particle clearance Source: Ensembl
- lipoprotein biosynthetic process Source: Ensembl
- locomotory exploration behavior Source: Ensembl
- long-chain fatty acid transport Source: Ensembl
- long-term memory Source: Ensembl
- negative regulation of amyloid-beta formation Source: Ensembl
- negative regulation of blood vessel endothelial cell migration Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of cholesterol biosynthetic process Source: Ensembl
- negative regulation of endothelial cell proliferation Source: Ensembl
- negative regulation of long-term synaptic potentiation Source: Ensembl
- negative regulation of MAP kinase activity Source: Ensembl
- negative regulation of neuron projection development Source: Ensembl
- negative regulation of platelet activation Source: Ensembl
- negative regulation of protein secretion Source: Ensembl
- neuron projection development Source: Ensembl
- nitric oxide mediated signal transduction Source: Ensembl
- NMDA glutamate receptor clustering Source: Ensembl
- phospholipid efflux Source: Ensembl
- positive regulation by host of viral process Source: Ensembl
- positive regulation of cholesterol efflux Source: Ensembl
- positive regulation of cholesterol esterification Source: Ensembl
- positive regulation of dendritic spine development Source: Ensembl
- positive regulation of dendritic spine maintenance Source: Ensembl
- positive regulation of endocytosis Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of heparan sulfate binding Source: Ensembl
- positive regulation of heparan sulfate proteoglycan binding Source: Ensembl
- positive regulation of lipid biosynthetic process Source: Ensembl
- positive regulation of lipid transport across blood-brain barrier Source: Ensembl
- positive regulation of low-density lipoprotein particle receptor catabolic process Source: Ensembl
- positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of nitric-oxide synthase activity Source: Ensembl
- positive regulation of phospholipid efflux Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- protein import Source: Ensembl
- receptor-mediated endocytosis Source: Ensembl
- regulation of amyloid-beta clearance Source: Ensembl
- regulation of amyloid fibril formation Source: Ensembl
- regulation of behavioral fear response Source: Ensembl
- regulation of Cdc42 protein signal transduction Source: Ensembl
- regulation of cellular response to very-low-density lipoprotein particle stimulus Source: Ensembl
- regulation of proteasomal protein catabolic process Source: Ensembl
- regulation of protein-containing complex assembly Source: Ensembl
- response to caloric restriction Source: Ensembl
- reverse cholesterol transport Source: Ensembl
- triglyceride metabolic process Source: Ensembl
- very-low-density lipoprotein particle clearance Source: Ensembl
- very-low-density lipoprotein particle remodeling Source: Ensembl
- virion assembly Source: Ensembl
Keywordsi
Biological process | Lipid transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:ApoeImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88057, Apoe |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Extracellular region or secreted
- chylomicron Source: Ensembl
- extracellular matrix Source: Ensembl
- high-density lipoprotein particle Source: UniProtKB-KW
- intermediate-density lipoprotein particle Source: Ensembl
- low-density lipoprotein particle Source: Ensembl
- synaptic cleft Source: Ensembl
- very-low-density lipoprotein particle Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- plasma membrane Source: GOC
Other locations
- glutamatergic synapse Source: Ensembl
Keywords - Cellular componenti
HDLARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5014309124 | 19 – 311 | Sequence analysisAdd BLAST | 293 |
Proteomic databases
MaxQBi | Q3TXU4 |
PeptideAtlasi | Q3TXU4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000002985, Expressed in olfactory bulb and 309 other tissues |
Interactioni
GO - Molecular functioni
- heparan sulfate proteoglycan binding Source: Ensembl
- low-density lipoprotein particle receptor binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- tau protein binding Source: Ensembl
- very-low-density lipoprotein particle receptor binding Source: Ensembl
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 67 – 87 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 111 – 138 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 148 – 175 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 232 – 259 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the apolipoprotein A1/A4/E family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_066029_0_0_1 |
OMAi | ARLKGWF |
OrthoDBi | 1314660at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3TXU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKALWAVLLV TLLTGCLAEG EPEVTDQLEW QSNQPWEQAL NRFWDYLRWV
60 70 80 90 100
QTLSDQVQEE LQSSQVTQEL TALMEDTMTE VKAYKKELEE QLGPVAEETR
110 120 130 140 150
ARLGKEVQAA QARLGADMED LRNRLGQYRN EVHTMLGQST EEIRARLSTH
160 170 180 190 200
LRKMRKRLMR DAEDLQKRLA VYKAGAREGA ERGVSAIRER LGPLVEQGRQ
210 220 230 240 250
RTANLGAGAA QPLRDRAQAF GDRIRGRLEE VGNQARDRLE EVREHMEEVR
260 270 280 290 300
SKMEEQTQQI RLQAEIFQAR LKGWFEPIVE DMHRQWANLM EKIQASVATN
310
PIITPVAQEN Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK134921 mRNA Translation: BAE22338.1 AK159105 mRNA Translation: BAE34821.1 AK159517 mRNA Translation: BAE35147.1 |
RefSeqi | NP_001292748.1, NM_001305819.1 NP_001292772.1, NM_001305843.1 NP_001292773.1, NM_001305844.1 NP_033826.2, NM_009696.4 |
Genome annotation databases
GeneIDi | 11816 |
KEGGi | mmu:11816 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK134921 mRNA Translation: BAE22338.1 AK159105 mRNA Translation: BAE34821.1 AK159517 mRNA Translation: BAE35147.1 |
RefSeqi | NP_001292748.1, NM_001305819.1 NP_001292772.1, NM_001305843.1 NP_001292773.1, NM_001305844.1 NP_033826.2, NM_009696.4 |
3D structure databases
SMRi | Q3TXU4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q3TXU4 |
PeptideAtlasi | Q3TXU4 |
Protocols and materials databases
Antibodypediai | 3639, 1401 antibodies |
Genome annotation databases
GeneIDi | 11816 |
KEGGi | mmu:11816 |
Organism-specific databases
CTDi | 348 |
MGIi | MGI:88057, Apoe |
Phylogenomic databases
HOGENOMi | CLU_066029_0_0_1 |
OMAi | ARLKGWF |
OrthoDBi | 1314660at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11816, 2 hits in 14 CRISPR screens |
ChiTaRSi | Apoe, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002985, Expressed in olfactory bulb and 309 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TXU4_MOUSE | |
Accessioni | Q3TXU4Primary (citable) accession number: Q3TXU4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |