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Entry version 133 (29 Sep 2021)
Sequence version 1 (11 Oct 2005)
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Protein

26S proteasome non-ATPase regulatory subunit 1

Gene

Psmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1169091, Activation of NF-kappaB in B cells
R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253, Degradation of beta-catenin by the destruction complex
R-MMU-202424, Downstream TCR signaling
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562, Regulation of ornithine decarboxylase (ODC)
R-MMU-382556, ABC-family proteins mediated transport
R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870, Asymmetric localization of PCP proteins
R-MMU-4641257, Degradation of AXIN
R-MMU-4641258, Degradation of DVL
R-MMU-5358346, Hedgehog ligand biogenesis
R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764, CLEC7A (Dectin-1) signaling
R-MMU-5610780, Degradation of GLI1 by the proteasome
R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684, Hedgehog 'on' state
R-MMU-5658442, Regulation of RAS by GAPs
R-MMU-5668541, TNFR2 non-canonical NF-kB pathway
R-MMU-5676590, NIK-->noncanonical NF-kB signaling
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-5689603, UCH proteinases
R-MMU-5689880, Ub-specific processing proteases
R-MMU-6798695, Neutrophil degranulation
R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949, Orc1 removal from chromatin
R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69481, G2/M Checkpoints
R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D
R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8932339, ROS sensing by NFE2L2
R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902, Regulation of RUNX2 expression and activity
R-MMU-8941858, Regulation of RUNX3 expression and activity
R-MMU-8948751, Regulation of PTEN stability and activity
R-MMU-8951664, Neddylation
R-MMU-9020702, Interleukin-1 signaling
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 1
Alternative name(s):
26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Psmd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917497, Psmd1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000026229

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002315981 – 95326S proteasome non-ATPase regulatory subunit 1Add BLAST953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei273PhosphothreonineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei310N6-acetyllysineCombined sources1
Modified residuei311PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei720N6-acetyllysineCombined sources1
Modified residuei830PhosphothreonineBy similarity1
Modified residuei834PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3TXS7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TXS7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TXS7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TXS7

PeptideAtlas

More...
PeptideAtlasi
Q3TXS7

PRoteomics IDEntifications database

More...
PRIDEi
Q3TXS7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
301989

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TXS7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TXS7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3TXS7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026229, Expressed in embryo and 326 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TXS7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1.

Interacts with ADRM1.

Interacts with ZFAND1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
213938, 61 interactors

Protein interaction database and analysis system

More...
IntActi
Q3TXS7, 6 interactors

Molecular INTeraction database

More...
MINTi
Q3TXS7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027432

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3TXS7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TXS7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati403 – 436PC 1Add BLAST34
Repeati441 – 474PC 2Add BLAST34
Repeati476 – 510PC 3Add BLAST35
Repeati511 – 545PC 4Add BLAST35
Repeati547 – 580PC 5Add BLAST34
Repeati581 – 616PC 6Add BLAST36
Repeati617 – 649PC 7Add BLAST33
Repeati651 – 685PC 8Add BLAST35
Repeati686 – 726PC 9Add BLAST41
Repeati729 – 761PC 10Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni277 – 319DisorderedSequence analysisAdd BLAST43
Regioni839 – 881DisorderedSequence analysisAdd BLAST43
Regioni930 – 953DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi839 – 874Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi939 – 953Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2062, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153386

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002323_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TXS7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMDIVQE

Database of Orthologous Groups

More...
OrthoDBi
235012at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TXS7

TreeFam database of animal gene trees

More...
TreeFami
TF105742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016642, 26S_Psome_Rpn2
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR035266, PSMD1
IPR040623, RPN2_C

The PANTHER Classification System

More...
PANTHERi
PTHR10943:SF2, PTHR10943:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01851, PC_rep, 3 hits
PF18004, RPN2_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015947, 26S_Psome_Rpn2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3TXS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITSAAGIIS LLDEEEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE
60 70 80 90 100
DEGFRSRQFA ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI
110 120 130 140 150
IAKCIDHYTK QCVENADLPE GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA
160 170 180 190 200
IGIALETRRL DVFEKTILES NDVPGMLAYS LKLCMSLMQN KQFRNKVLRV
210 220 230 240 250
LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED NLLMAYQICF
260 270 280 290 300
DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDPMETE
310 320 330 340 350
EKTASAVAGK TPDASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL
360 370 380 390 400
MILKNTKDAV RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA
410 420 430 440 450
KFTATASLGV IHKGHEKEAL QLMATYLPKD TSPGSAYQEG GGLYALGLIH
460 470 480 490 500
ANHGGDIIDY LLNQLKNASN DIVRHGGSLG LGLAAMGTAR QDVYDLLKTN
510 520 530 540 550
LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ HEKILRGLAV
560 570 580 590 600
GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR
610 620 630 640 650
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY
660 670 680 690 700
GAAMALGICC AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE
710 720 730 740 750
ITCPKVNQFR QLYSKVINDK HDDVMAKFGA ILAQGILDAG GHNVTISLQS
760 770 780 790 800
RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS LAYTPTCVIG LNKDLKMPKV
810 820 830 840 850
QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK KKEKEKEKKE
860 870 880 890 900
EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLSMTETCRY
910 920 930 940 950
QPFKPLSIGG IIILKDTSED VEELVEPVAA HGPKIEEEEQ EPEPPEPFEY

IDD
Length:953
Mass (Da):105,730
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40A72A08CFC778E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGR5D6RGR5_MOUSE
26S proteasome non-ATPase regulator...
Psmd1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK153386 mRNA Translation: BAE31950.1
AK159123 mRNA Translation: BAE34838.1
BC138526 mRNA Translation: AAI38527.1
BC138527 mRNA Translation: AAI38528.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15117.1

NCBI Reference Sequences

More...
RefSeqi
NP_081633.1, NM_027357.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027432; ENSMUSP00000027432; ENSMUSG00000026229

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70247

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70247

UCSC genome browser

More...
UCSCi
uc007buy.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153386 mRNA Translation: BAE31950.1
AK159123 mRNA Translation: BAE34838.1
BC138526 mRNA Translation: AAI38527.1
BC138527 mRNA Translation: AAI38528.1
CCDSiCCDS15117.1
RefSeqiNP_081633.1, NM_027357.2

3D structure databases

SMRiQ3TXS7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi213938, 61 interactors
IntActiQ3TXS7, 6 interactors
MINTiQ3TXS7
STRINGi10090.ENSMUSP00000027432

PTM databases

iPTMnetiQ3TXS7
PhosphoSitePlusiQ3TXS7
SwissPalmiQ3TXS7

Proteomic databases

EPDiQ3TXS7
jPOSTiQ3TXS7
MaxQBiQ3TXS7
PaxDbiQ3TXS7
PeptideAtlasiQ3TXS7
PRIDEiQ3TXS7
ProteomicsDBi301989

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34412, 134 antibodies

Genome annotation databases

EnsembliENSMUST00000027432; ENSMUSP00000027432; ENSMUSG00000026229
GeneIDi70247
KEGGimmu:70247
UCSCiuc007buy.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5707
MGIiMGI:1917497, Psmd1
VEuPathDBiHostDB:ENSMUSG00000026229

Phylogenomic databases

eggNOGiKOG2062, Eukaryota
GeneTreeiENSGT00940000153386
HOGENOMiCLU_002323_0_0_1
InParanoidiQ3TXS7
OMAiCMDIVQE
OrthoDBi235012at2759
PhylomeDBiQ3TXS7
TreeFamiTF105742

Enzyme and pathway databases

ReactomeiR-MMU-1169091, Activation of NF-kappaB in B cells
R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253, Degradation of beta-catenin by the destruction complex
R-MMU-202424, Downstream TCR signaling
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562, Regulation of ornithine decarboxylase (ODC)
R-MMU-382556, ABC-family proteins mediated transport
R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870, Asymmetric localization of PCP proteins
R-MMU-4641257, Degradation of AXIN
R-MMU-4641258, Degradation of DVL
R-MMU-5358346, Hedgehog ligand biogenesis
R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764, CLEC7A (Dectin-1) signaling
R-MMU-5610780, Degradation of GLI1 by the proteasome
R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684, Hedgehog 'on' state
R-MMU-5658442, Regulation of RAS by GAPs
R-MMU-5668541, TNFR2 non-canonical NF-kB pathway
R-MMU-5676590, NIK-->noncanonical NF-kB signaling
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-5689603, UCH proteinases
R-MMU-5689880, Ub-specific processing proteases
R-MMU-6798695, Neutrophil degranulation
R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949, Orc1 removal from chromatin
R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69481, G2/M Checkpoints
R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D
R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8932339, ROS sensing by NFE2L2
R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902, Regulation of RUNX2 expression and activity
R-MMU-8941858, Regulation of RUNX3 expression and activity
R-MMU-8948751, Regulation of PTEN stability and activity
R-MMU-8951664, Neddylation
R-MMU-9020702, Interleukin-1 signaling
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
70247, 25 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Psmd1, mouse

Protein Ontology

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PROi
PR:Q3TXS7
RNActiQ3TXS7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026229, Expressed in embryo and 326 other tissues
GenevisibleiQ3TXS7, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016642, 26S_Psome_Rpn2
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR035266, PSMD1
IPR040623, RPN2_C
PANTHERiPTHR10943:SF2, PTHR10943:SF2, 1 hit
PfamiView protein in Pfam
PF01851, PC_rep, 3 hits
PF18004, RPN2_C, 1 hit
PIRSFiPIRSF015947, 26S_Psome_Rpn2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TXS7
Secondary accession number(s): B2RRP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2005
Last modified: September 29, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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