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Protein

Serine/arginine-rich splicing factor 6

Gene

Srsf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 6
Alternative name(s):
Pre-mRNA-splicing factor SRP55
Splicing factor, arginine/serine-rich 6
Gene namesi
Name:Srsf6
Synonyms:Sfrs6, Srp55
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915246 Srsf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004260951 – 339Serine/arginine-rich splicing factor 6Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei81PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei165N6-acetyllysineCombined sources1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei297PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei303Phosphoserine; by DYRK1ABy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei316PhosphoserineBy similarity1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10 (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3TWW8
MaxQBiQ3TWW8
PaxDbiQ3TWW8
PeptideAtlasiQ3TWW8
PRIDEiQ3TWW8

PTM databases

iPTMnetiQ3TWW8
PhosphoSitePlusiQ3TWW8

Expressioni

Gene expression databases

BgeeiENSMUSG00000016921 Expressed in 302 organ(s), highest expression level in metanephric loop of Henle
ExpressionAtlasiQ3TWW8 baseline and differential
GenevisibleiQ3TWW8 MM

Interactioni

Subunit structurei

Binds SREK1/SFRS12. Interacts with DYRK1A (By similarity).By similarity

Protein-protein interaction databases

BioGridi212588, 2 interactors
IntActiQ3TWW8, 3 interactors
STRINGi10090.ENSMUSP00000119065

Structurei

3D structure databases

ProteinModelPortaliQ3TWW8
SMRiQ3TWW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini110 – 183RRM 2PROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 90Gly-rich (hinge region)4
Compositional biasi184 – 338Arg/Ser-rich (RS domain)Add BLAST155

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOGENOMiHOG000276234
HOVERGENiHBG002295
InParanoidiQ3TWW8
KOiK12893
OMAiVDCRVMT
OrthoDBiEOG091G0R9W
PhylomeDBiQ3TWW8
TreeFamiTF351335

Family and domain databases

CDDicd12596 RRM1_SRSF6, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034511 SRSF6_RRM1
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3TWW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRVYIGRLS YNVREKDIQR FFSGYGRLLE IDLKNGYGFV EFEDSRDADD
60 70 80 90 100
AVYELNSKEL CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD
110 120 130 140 150
KYGPPVRTEY RLIVENLSSR CSWQDLKDFM RQAGEVTYAD AHKERTNEGV
160 170 180 190 200
IEFRSYSDMK RALDKLDGTE INGRNIRLIE DKPRTSHRRS YSGSRSRSRS
210 220 230 240 250
RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG RKSRSKSKSK
260 270 280 290 300
PKSDRGSHSH SRSRSKDKYG KSRSRSRSRS PKENGKGDIK SKSRSRSQSR
310 320 330
SHSPLPAPPS KARSMSPPPK RASRSRSRSR SRSRSSSRD
Length:339
Mass (Da):39,025
Last modified:October 11, 2005 - v1
Checksum:iAE8B6650D7294A0D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXX6A0A0A6YXX6_MOUSE
Serine/arginine-rich-splicing facto...
Srsf6
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201R → K in BAB23599 (PubMed:16141072).Curated1
Sequence conflicti230S → G in BAE27050 (PubMed:16141072).Curated1
Sequence conflicti299S → P in BAE27050 (PubMed:16141072).Curated1
Sequence conflicti319P → T in AAH12039 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004831 mRNA Translation: BAB23599.1
AK133872 mRNA Translation: BAE21902.1
AK146293 mRNA Translation: BAE27050.1
AK159519 mRNA Translation: BAE35148.1
AL590418 Genomic DNA No translation available.
AL606473 Genomic DNA No translation available.
CH466551 Genomic DNA Translation: EDL06308.1
BC012039 mRNA Translation: AAH12039.1
CCDSiCCDS17002.1
RefSeqiNP_080775.3, NM_026499.4
UniGeneiMm.24042

Genome annotation databases

EnsembliENSMUST00000130411; ENSMUSP00000119065; ENSMUSG00000016921
GeneIDi67996
KEGGimmu:67996
UCSCiuc008nsc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004831 mRNA Translation: BAB23599.1
AK133872 mRNA Translation: BAE21902.1
AK146293 mRNA Translation: BAE27050.1
AK159519 mRNA Translation: BAE35148.1
AL590418 Genomic DNA No translation available.
AL606473 Genomic DNA No translation available.
CH466551 Genomic DNA Translation: EDL06308.1
BC012039 mRNA Translation: AAH12039.1
CCDSiCCDS17002.1
RefSeqiNP_080775.3, NM_026499.4
UniGeneiMm.24042

3D structure databases

ProteinModelPortaliQ3TWW8
SMRiQ3TWW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212588, 2 interactors
IntActiQ3TWW8, 3 interactors
STRINGi10090.ENSMUSP00000119065

PTM databases

iPTMnetiQ3TWW8
PhosphoSitePlusiQ3TWW8

Proteomic databases

EPDiQ3TWW8
MaxQBiQ3TWW8
PaxDbiQ3TWW8
PeptideAtlasiQ3TWW8
PRIDEiQ3TWW8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130411; ENSMUSP00000119065; ENSMUSG00000016921
GeneIDi67996
KEGGimmu:67996
UCSCiuc008nsc.2 mouse

Organism-specific databases

CTDi6431
MGIiMGI:1915246 Srsf6

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOGENOMiHOG000276234
HOVERGENiHBG002295
InParanoidiQ3TWW8
KOiK12893
OMAiVDCRVMT
OrthoDBiEOG091G0R9W
PhylomeDBiQ3TWW8
TreeFamiTF351335

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiSrsf6 mouse
PROiPR:Q3TWW8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016921 Expressed in 302 organ(s), highest expression level in metanephric loop of Henle
ExpressionAtlasiQ3TWW8 baseline and differential
GenevisibleiQ3TWW8 MM

Family and domain databases

CDDicd12596 RRM1_SRSF6, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034511 SRSF6_RRM1
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSRSF6_MOUSE
AccessioniPrimary (citable) accession number: Q3TWW8
Secondary accession number(s): Q3UJV5, Q921K3, Q9DBP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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