UniProtKB - Q3TWI9 (CSCL2_MOUSE)
Protein
CSC1-like protein 2
Gene
Tmem63b
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as an osmosensitive calcium-permeable cation channel (PubMed:27045885, PubMed:31243992). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (PubMed:30382938).3 Publications
GO - Molecular functioni
- calcium activated cation channel activity Source: UniProtKB
- mechanosensitive ion channel activity Source: UniProtKB
- osmolarity-sensing cation channel activity Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: CSC1-like protein 2Alternative name(s): Transmembrane protein 63B |
Gene namesi | Name:Tmem63b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2387609, Tmem63b |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Cytoskeleton
- actin cytoskeleton Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 435 – 455 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 481 – 501 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 521 – 541 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 560 – 580 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 630 – 650 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 678 – 698 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 711 – 731 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280729 | 1 – 832 | CSC1-like protein 2Add BLAST | 832 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 111 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 114 | PhosphoserineCombined sources | 1 | |
Modified residuei | 115 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q3TWI9 |
MaxQBi | Q3TWI9 |
PaxDbi | Q3TWI9 |
PeptideAtlasi | Q3TWI9 |
PRIDEi | Q3TWI9 |
PTM databases
iPTMneti | Q3TWI9 |
PhosphoSitePlusi | Q3TWI9 |
SwissPalmi | Q3TWI9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036026, Expressed in retinal neural layer and 278 other tissues |
ExpressionAtlasi | Q3TWI9, baseline and differential |
Genevisiblei | Q3TWI9, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 230322, 3 interactors |
IntActi | Q3TWI9, 1 interactor |
STRINGi | 10090.ENSMUSP00000109151 |
Miscellaneous databases
RNActi | Q3TWI9, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1134, Eukaryota |
GeneTreei | ENSGT00940000157084 |
HOGENOMi | CLU_015647_0_0_1 |
InParanoidi | Q3TWI9 |
OMAi | WLWVHTI |
OrthoDBi | 395194at2759 |
PhylomeDBi | Q3TWI9 |
TreeFami | TF324300 |
Family and domain databases
InterProi | View protein in InterPro IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q3TWI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPFLLATLG TAALNSSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM
60 70 80 90 100
CFLALLFLFS ILRKVAWDYG RLALVTDADR LRRQERERVE QEYVASAMHG
110 120 130 140 150
DSHDRYERLT SVSSSVDFDQ RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH
160 170 180 190 200
YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG DLLENNAYSF GRTTIANLKS
210 220 230 240 250
GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR TLFINGISKY
260 270 280 290 300
AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
310 320 330 340 350
LQSKENVPAM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QRLKEDYRRE
360 370 380 390 400
KEKVNEKPLG MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRASSCSE
410 420 430 440 450
ALHISNWTVT YAPDPQNIYW EHLSIRGFIW WLRCLVINVV LFILLFFLTT
460 470 480 490 500
PAIIITTMDK FNVTKPVEYL NNPIITQFFP TLLLWCFSAL LPTIVYYSAF
510 520 530 540 550
FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF FRWLFDKKFL
560 570 580 590 600
AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
610 620 630 640 650
ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM
660 670 680 690 700
YMLLKHLVDR YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST
710 720 730 740 750
MRTGFLAPTS MFTFVVLVIT IVICLCHVCF GHFKYLSAHN YKIEHTETDA
760 770 780 790 800
VSSRSNGRPP TAGAVPKSAK YIAQVLQDSE GDGDGDGAPG SSGDEPPSSS
810 820 830
SQDEELLMPP DGLTDTDFQS CEDSLIENEI HQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z2D8 | D3Z2D8_MOUSE | CSC1-like protein 2 | Tmem63b | 309 | Annotation score: | ||
D3YY83 | D3YY83_MOUSE | CSC1-like protein 2 | Tmem63b | 264 | Annotation score: | ||
D3Z0P2 | D3Z0P2_MOUSE | CSC1-like protein 2 | Tmem63b | 218 | Annotation score: | ||
D3YXV7 | D3YXV7_MOUSE | CSC1-like protein 2 | Tmem63b | 92 | Annotation score: | ||
D3YYJ8 | D3YYJ8_MOUSE | CSC1-like protein 2 | Tmem63b | 200 | Annotation score: |
Sequence cautioni
The sequence AAH57136 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH59283 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 619 | Q → R in BAC41131 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 725 | L → P in AAH26370 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090200 mRNA Translation: BAC41131.1 AK159673 mRNA Translation: BAE35277.1 BC026370 mRNA Translation: AAH26370.1 BC057136 mRNA Translation: AAH57136.1 Different initiation. BC059283 mRNA Translation: AAH59283.1 Different initiation. |
CCDSi | CCDS28814.1 |
RefSeqi | NP_937810.2, NM_198167.3 XP_006524199.1, XM_006524136.1 XP_006524200.1, XM_006524137.2 |
Genome annotation databases
Ensembli | ENSMUST00000113523; ENSMUSP00000109151; ENSMUSG00000036026 |
GeneIDi | 224807 |
KEGGi | mmu:224807 |
UCSCi | uc012auh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090200 mRNA Translation: BAC41131.1 AK159673 mRNA Translation: BAE35277.1 BC026370 mRNA Translation: AAH26370.1 BC057136 mRNA Translation: AAH57136.1 Different initiation. BC059283 mRNA Translation: AAH59283.1 Different initiation. |
CCDSi | CCDS28814.1 |
RefSeqi | NP_937810.2, NM_198167.3 XP_006524199.1, XM_006524136.1 XP_006524200.1, XM_006524137.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 230322, 3 interactors |
IntActi | Q3TWI9, 1 interactor |
STRINGi | 10090.ENSMUSP00000109151 |
PTM databases
iPTMneti | Q3TWI9 |
PhosphoSitePlusi | Q3TWI9 |
SwissPalmi | Q3TWI9 |
Proteomic databases
jPOSTi | Q3TWI9 |
MaxQBi | Q3TWI9 |
PaxDbi | Q3TWI9 |
PeptideAtlasi | Q3TWI9 |
PRIDEi | Q3TWI9 |
Protocols and materials databases
Antibodypediai | 30591, 35 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000113523; ENSMUSP00000109151; ENSMUSG00000036026 |
GeneIDi | 224807 |
KEGGi | mmu:224807 |
UCSCi | uc012auh.1, mouse |
Organism-specific databases
CTDi | 55362 |
MGIi | MGI:2387609, Tmem63b |
Phylogenomic databases
eggNOGi | KOG1134, Eukaryota |
GeneTreei | ENSGT00940000157084 |
HOGENOMi | CLU_015647_0_0_1 |
InParanoidi | Q3TWI9 |
OMAi | WLWVHTI |
OrthoDBi | 395194at2759 |
PhylomeDBi | Q3TWI9 |
TreeFami | TF324300 |
Miscellaneous databases
BioGRID-ORCSi | 224807, 1 hit in 18 CRISPR screens |
ChiTaRSi | Tmem63b, mouse |
PROi | PR:Q3TWI9 |
RNActi | Q3TWI9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036026, Expressed in retinal neural layer and 278 other tissues |
ExpressionAtlasi | Q3TWI9, baseline and differential |
Genevisiblei | Q3TWI9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR032880, Csc1_N IPR027815, PHM7_cyt IPR003864, RSN1_7TM |
Pfami | View protein in Pfam PF14703, PHM7_cyt, 1 hit PF02714, RSN1_7TM, 1 hit PF13967, RSN1_TM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSCL2_MOUSE | |
Accessioni | Q3TWI9Primary (citable) accession number: Q3TWI9 Secondary accession number(s): Q6PCL2 Q8R0W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families