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UniProtKB - Q3TWH5 (Q3TWH5_MOUSE)
Protein
Transforming growth factor beta-2 proprotein
Gene
Tgfb2
Organism
Mus musculus (Mouse)
Status
Functioni
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
ARBA annotationGO - Molecular functioni
- amyloid-beta binding Source: AgBase
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: AgBase
- signaling receptor binding Source: AgBase
- transforming growth factor beta receptor binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
GO - Biological processi
- activation of protein kinase activity Source: AgBase
- cardiac epithelial to mesenchymal transition Source: AgBase
- cardiac muscle cell proliferation Source: AgBase
- cardioblast differentiation Source: AgBase
- cell-cell junction organization Source: AgBase
- cell death Source: AgBase
- cell migration Source: AgBase
- cell morphogenesis Source: AgBase
- collagen fibril organization Source: AgBase
- embryonic digestive tract development Source: AgBase
- epithelial to mesenchymal transition Source: AgBase
- extrinsic apoptotic signaling pathway Source: AgBase
- eye development Source: AgBase
- glial cell migration Source: AgBase
- hair follicle development Source: AgBase
- heart development Source: AgBase
- heart morphogenesis Source: AgBase
- negative regulation of alkaline phosphatase activity Source: AgBase
- negative regulation of cell growth Source: AgBase
- negative regulation of cell population proliferation Source: AgBase
- negative regulation of epithelial cell proliferation Source: AgBase
- negative regulation of macrophage cytokine production Source: AgBase
- pathway-restricted SMAD protein phosphorylation Source: AgBase
- positive regulation of cardioblast differentiation Source: AgBase
- positive regulation of cell adhesion mediated by integrin Source: AgBase
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell growth Source: AgBase
- positive regulation of cell population proliferation Source: AgBase
- positive regulation of epithelial cell migration Source: AgBase
- positive regulation of epithelial to mesenchymal transition Source: AgBase
- positive regulation of heart contraction Source: AgBase
- positive regulation of integrin biosynthetic process Source: AgBase
- positive regulation of neuron apoptotic process Source: AgBase
- positive regulation of ossification Source: AgBase
- positive regulation of phosphatidylinositol 3-kinase signaling Source: AgBase
- positive regulation of protein secretion Source: AgBase
- positive regulation of stress-activated MAPK cascade Source: AgBase
- positive regulation of timing of catagen Source: AgBase
- protein phosphorylation Source: AgBase
- regulation of cell population proliferation Source: AgBase
- regulation of transforming growth factor beta2 production Source: AgBase
- response to progesterone Source: AgBase
- response to wounding Source: AgBase
- response to xenobiotic stimulus Source: AgBase
- salivary gland morphogenesis Source: AgBase
- signal transduction Source: AgBase
- SMAD protein signal transduction Source: AgBase
- transforming growth factor beta receptor signaling pathway Source: AgBase
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation, MitogenARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-2 proproteinARBA annotation |
Gene namesi | Name:Tgfb2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98726, Tgfb2 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix ARBA annotation
Extracellular region or secreted
- extracellular space Source: InterPro
Other locations
- extracellular matrix Source: AgBase
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 236 ↔ 245 | UniRule annotation | ||
Disulfide bondi | 244 ↔ 307 | UniRule annotation | ||
Disulfide bondi | 273 ↔ 338 | UniRule annotation | ||
Disulfide bondi | 277 ↔ 340 | UniRule annotation | ||
Disulfide bondi | 306 | InterchainUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotationProteomic databases
PeptideAtlasi | Q3TWH5 |
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: AgBase
- signaling receptor binding Source: AgBase
- transforming growth factor beta receptor binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 226 – 341 | TGF_BETA_2InterPro annotationAdd BLAST | 116 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q3TWH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
TRDLLQEKAS RRAAACERER SDEEYYAKEV YKIDMPSHLP SENAIPPTFY
60 70 80 90 100
RPYFRIVRFD VSTMEKNASN LVKAEFRVFR LQNPKARVAE QRIELYQILK
110 120 130 140 150
SKDLTSPTQR YIDSKVVKTR AEGEWLSFDV TDAVQEWLHH KDRNLGFKIS
160 170 180 190 200
LHCPCCTFVP SNNYIIPNKS EELEARFAGI DGTSTYASGD QKTIKSTRKK
210 220 230 240 250
TSGKTPHLLL MLLPSYRLES QQSSRRKKRA LDAAYCFRNV QDNCCLRPLY
260 270 280 290 300
IDFKRDLGWK WIHEPKGYNA NFCAGACPYL WSSDTQHTKV LSLYNTINPE
310 320 330 340
ASASPCCVSQ DLEPLTILYY IGNTPKIEQL SNMIVKSCKC S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK159690 mRNA Translation: BAE35291.1 |
RefSeqi | NP_001316036.1, NM_001329107.1 NP_033393.2, NM_009367.4 |
Genome annotation databases
GeneIDi | 21808 |
KEGGi | mmu:21808 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK159690 mRNA Translation: BAE35291.1 |
RefSeqi | NP_001316036.1, NM_001329107.1 NP_033393.2, NM_009367.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q3TWH5 |
Protocols and materials databases
DNASUi | 21808 |
Genome annotation databases
GeneIDi | 21808 |
KEGGi | mmu:21808 |
Organism-specific databases
CTDi | 7042 |
MGIi | MGI:98726, Tgfb2 |
Miscellaneous databases
BioGRID-ORCSi | 21808, 0 hits in 66 CRISPR screens |
ChiTaRSi | Tgfb2, mouse |
SOURCEi | Search... |
Gene expression databases
Genevisiblei | Q3TWH5, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TWH5_MOUSE | |
Accessioni | Q3TWH5Primary (citable) accession number: Q3TWH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | January 19, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |