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Entry version 98 (08 May 2019)
Sequence version 1 (11 Oct 2005)
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Protein

UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

Gene

Uap1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei125UTPBy similarity1
Binding sitei199UTPBy similarity1
Binding sitei225UTP; via amide nitrogenBy similarity1
Binding sitei226SubstrateBy similarity1
Binding sitei256UTPBy similarity1
Binding sitei380UTPBy similarity1
Binding sitei410SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC:2.7.7.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Uap1l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443318 Uap1l1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003245811 – 507UDP-N-acetylhexosamine pyrophosphorylase-like protein 1Add BLAST507

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3TW96

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TW96

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TW96

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TW96

PeptideAtlas

More...
PeptideAtlasi
Q3TW96

PRoteomics IDEntifications database

More...
PRIDEi
Q3TW96

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TW96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TW96

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3TW96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026956 Expressed in 193 organ(s), highest expression level in small intestine

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TW96 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230646, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099989

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TW96

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 114UTP bindingBy similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi111 – 114Substrate binding4
Motifi306 – 307Substrate binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2388 Eukaryota
COG4284 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153464

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TW96

KEGG Orthology (KO)

More...
KOi
K00972

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCTVPWY

Database of Orthologous Groups

More...
OrthoDBi
888726at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TW96

TreeFam database of animal gene trees

More...
TreeFami
TF300611

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR039741 UDP-sugar_pyrophosphorylase
IPR002618 UDPGP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11952 PTHR11952, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01704 UDPGP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3TW96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSERDVRAQ LQRAGQDHLL RFYADLAPEA RAALLAELAS LEADALREHC
60 70 80 90 100
QRAAAAGALA PGPLPDLAAR LQPLPPERVG SAIRCDQETR LRWEEEGFRQ
110 120 130 140 150
ISLNKVAVLL LAGGQGTRLG VTYPKGMYQV GLPSQKTLYQ LQAERIRRVQ
160 170 180 190 200
QLADQRQGTH CTVPWYIMTS EFTLGPTIKF FKEHDFFHLD PTNVVLFEQR
210 220 230 240 250
MLPAVTFEGK AILERKDKVA MAPDGNGGLY CALADHQILE DMKQRGVEFV
260 270 280 290 300
HVYCVDNILV RLADPVFIGF CVLQGADCGA KVVEKAYPEE PVGVVCQVDG
310 320 330 340 350
VPQVVEYSEI SPEIAGQLGA DGGLLYNAGN ICNHFFTRGF LDVVTREFEP
360 370 380 390 400
LLRLHVAMKK VPYVDEEGNL VKPLRPNGIK MEKFVFDVFQ FAKNFVAFEV
410 420 430 440 450
CREEEFSPLK NDDTADRDNP STCRRALLAQ HYRWALQAGA RFLDVHGVQL
460 470 480 490 500
TEQSGMLPNG DPPAICEISP LVSYSGEGLE MYLQGRQLQS PFILDEDQAR

LLRPQDC
Length:507
Mass (Da):56,614
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4972BE7DBA6C1A1
GO
Isoform 2 (identifier: Q3TW96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,968
Checksum:i0C399AC539E3D445
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH43307 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD21409 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0322811 – 126Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK151942 mRNA Translation: BAE30818.1
AK159787 mRNA Translation: BAE35370.1
AK168977 mRNA Translation: BAE40778.1
AL732557 Genomic DNA No translation available.
BC043307 mRNA Translation: AAH43307.1 Different initiation.
BC068207 mRNA Translation: AAH68207.1
BC130030 mRNA Translation: AAI30031.1
AK131159 Transcribed RNA Translation: BAD21409.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15767.1 [Q3TW96-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001028465.1, NM_001033293.2 [Q3TW96-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000102925; ENSMUSP00000099989; ENSMUSG00000026956 [Q3TW96-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
227620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:227620

UCSC genome browser

More...
UCSCi
uc008irr.1 mouse [Q3TW96-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151942 mRNA Translation: BAE30818.1
AK159787 mRNA Translation: BAE35370.1
AK168977 mRNA Translation: BAE40778.1
AL732557 Genomic DNA No translation available.
BC043307 mRNA Translation: AAH43307.1 Different initiation.
BC068207 mRNA Translation: AAH68207.1
BC130030 mRNA Translation: AAI30031.1
AK131159 Transcribed RNA Translation: BAD21409.1 Sequence problems.
CCDSiCCDS15767.1 [Q3TW96-1]
RefSeqiNP_001028465.1, NM_001033293.2 [Q3TW96-1]

3D structure databases

SMRiQ3TW96
ModBaseiSearch...

Protein-protein interaction databases

BioGridi230646, 2 interactors
STRINGi10090.ENSMUSP00000099989

PTM databases

iPTMnetiQ3TW96
PhosphoSitePlusiQ3TW96
SwissPalmiQ3TW96

Proteomic databases

EPDiQ3TW96
jPOSTiQ3TW96
MaxQBiQ3TW96
PaxDbiQ3TW96
PeptideAtlasiQ3TW96
PRIDEiQ3TW96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102925; ENSMUSP00000099989; ENSMUSG00000026956 [Q3TW96-1]
GeneIDi227620
KEGGimmu:227620
UCSCiuc008irr.1 mouse [Q3TW96-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91373
MGIiMGI:2443318 Uap1l1

Phylogenomic databases

eggNOGiKOG2388 Eukaryota
COG4284 LUCA
GeneTreeiENSGT00940000153464
InParanoidiQ3TW96
KOiK00972
OMAiRCTVPWY
OrthoDBi888726at2759
PhylomeDBiQ3TW96
TreeFamiTF300611

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Uap1l1 mouse

Protein Ontology

More...
PROi
PR:Q3TW96

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026956 Expressed in 193 organ(s), highest expression level in small intestine
GenevisibleiQ3TW96 MM

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR039741 UDP-sugar_pyrophosphorylase
IPR002618 UDPGP_fam
PANTHERiPTHR11952 PTHR11952, 1 hit
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUAP1L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TW96
Secondary accession number(s): A1L3D3
, Q6KAP8, Q6NVB6, Q80XP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: May 8, 2019
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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