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Protein
Submitted name:

Uncharacterized protein

Gene

Ldlr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:LdlrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96765 Ldlr

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei791 – 812HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500422972124 – 862Sequence analysisAdd BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi89 ↔ 104PROSITE-ProRule annotation
Disulfide bondi109 ↔ 121PROSITE-ProRule annotation
Disulfide bondi116 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 143PROSITE-ProRule annotation
Disulfide bondi148 ↔ 160PROSITE-ProRule annotation
Disulfide bondi155 ↔ 173PROSITE-ProRule annotation
Disulfide bondi198 ↔ 210PROSITE-ProRule annotation
Disulfide bondi205 ↔ 223PROSITE-ProRule annotation
Disulfide bondi217 ↔ 232PROSITE-ProRule annotation
Disulfide bondi237 ↔ 249PROSITE-ProRule annotation
Disulfide bondi244 ↔ 262PROSITE-ProRule annotation
Disulfide bondi256 ↔ 271PROSITE-ProRule annotation
Disulfide bondi285 ↔ 303PROSITE-ProRule annotation
Disulfide bondi359 ↔ 369PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiQ3TVR4

Interactioni

Protein-protein interaction databases

IntActiQ3TVR4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ3TVR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 354EGF-likeInterPro annotationAdd BLAST40
Domaini355 – 394EGF-likeInterPro annotationAdd BLAST40
Repeati440 – 485LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati486 – 528LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati529 – 572LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati573 – 617LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati618 – 658LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410KD0U Eukaryota
ENOG410Z5FJ LUCA
HOVERGENiHBG006250

Family and domain databases

CDDicd00112 LDLa, 7 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 7 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 7 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 7 hits
PS51120 LDLRB, 5 hits

Sequencei

Sequence statusi: Complete.

Q3TVR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTADLMRRW VIALLLAAAG VAAEDSCSRN EFQCRDGKCI ASKWVCDGSP
60 70 80 90 100
ECPDGSDESP ETCMSVTCQS NQFSCGGRVS RCIPDSWRCD GQVDCENDSD
110 120 130 140 150
EQGCPPKTCS QDDFRCQDGK CISPQFVCDG DRDCLDGSDE AHCQATTCGP
160 170 180 190 200
AHFRCNSSIC IPSLWACDGD VDCVDGSDEW PQNCQGRDTA SKGVSSPCSS
210 220 230 240 250
LEFHCGSSEC IHRSWVCDGE ADCKDKSDEE HCAVATCRPD EFQCADGSCI
260 270 280 290 300
HGSRQCDREH DCKDMSDELG CVNVTQCDGP NKFKCHSGEC ISLDKVCDSA
310 320 330 340 350
RDCQDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGSECL CPSGFRLVDL
360 370 380 390 400
HRCEDIDECQ EPDTCSQLCV NLEGSYKCEC QAGFHMDPHT RVCKAVGSIG
410 420 430 440 450
YLLFTNRHEV RKMTLDRSEY TSLLPNLKNV VALDTEVTNN RIYWSDLSQK
460 470 480 490 500
KIYSALMDQA PNLSYDTIIS EDLHAPDGLA VDWIHRNIYW TDSVPGSVSV
510 520 530 540 550
ADTKGVKRRT LFQEAGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV
560 570 580 590 600
DIHSLVTENI QWPNGITLDL SSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650
DENRLAHPFS LAIYEDKVYW TDVINEAIFS ANRLTGSDVN LVAENLLSPE
660 670 680 690 700
DIVLFHKVTQ PRGVNWCETT ALLPNGGCQY LCLPAPQIGP HSPKFTCACP
710 720 730 740 750
DGMLLAKDMR SCLTEVDTVL TTQGTSAVRP VVTASATRPP KHSEDLSAPS
760 770 780 790 800
TPRQPVDTPG LSTVASVTVS HQVQGDMAGR GNEEQPHGMR FLSIFFPIAL
810 820 830 840 850
VALLVLGAVL LWRNWRLKNI NSINFGNPVY QKTTEDELHI CRSQDGYTYP
860
SRQMVSLEDD VA
Length:862
Mass (Da):94,889
Last modified:October 11, 2005 - v1
Checksum:i43E7D6A291434F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160006 mRNA Translation: BAE35554.1
UniGeneiMm.3213

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160006 mRNA Translation: BAE35554.1
UniGeneiMm.3213

3D structure databases

ProteinModelPortaliQ3TVR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TVR4, 1 interactor

Proteomic databases

PeptideAtlasiQ3TVR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96765 Ldlr

Phylogenomic databases

eggNOGiENOG410KD0U Eukaryota
ENOG410Z5FJ LUCA
HOVERGENiHBG006250

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

CDDicd00112 LDLa, 7 hits
Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 7 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 7 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 6 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 7 hits
PS51120 LDLRB, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ3TVR4_MOUSE
AccessioniPrimary (citable) accession number: Q3TVR4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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