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UniProtKB - Q3TVF4 (Q3TVF4_MOUSE)
Protein
Geranylgeranyl transferase type-2 subunit beta
Gene
Rabggtb
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.
UniRule annotationCatalytic activityi
- geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]UniRule annotationARBA annotationEC:2.5.1.60UniRule annotationARBA annotation
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- Rab geranylgeranyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- protein geranylgeranylation Source: UniProtKB-UniRule
Keywordsi
Molecular function | PrenyltransferaseUniRule annotationARBA annotation, Transferase |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Geranylgeranyl transferase type-2 subunit betaUniRule annotation (EC:2.5.1.60UniRule annotation) |
Gene namesi | Name:RabggtbImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99537, Rabggtb |
VEuPathDBi | HostDB:ENSMUSG00000038975 |
Subcellular locationi
Other locations
- Rab-protein geranylgeranyltransferase complex Source: UniProtKB-UniRule
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038975, Expressed in cumulus cell and 316 other tissues |
Structurei
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183128 |
HOGENOMi | CLU_028946_3_0_1 |
OMAi | VKRCQCP |
OrthoDBi | 1042804at2759 |
Family and domain databases
CDDi | cd02894, GGTase-II, 1 hit |
InterProi | View protein in InterPro IPR001330, PFTB_repeat IPR045089, PGGT1B-like IPR026873, Ptb1 IPR008930, Terpenoid_cyclase/PrenylTrfase |
PANTHERi | PTHR11774, PTHR11774, 1 hit |
Pfami | View protein in Pfam PF00432, Prenyltrans, 5 hits |
SUPFAMi | SSF48239, SSF48239, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q3TVF4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTQQKDVTI KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGV
60 70 80 90 100
YWGLTVMDLM GQLHRMNREE ILVFIKSCQH ECGGISASIG HDPHLLYTLS
110 120 130 140 150
AVQILTLYDS VHVINVDKVV AYVQSLQKED GSFAGDIWGE IDTRFSFCAV
160 170 180 190 200
ATLALLGKLD AINVEKAIEF VLSCMNFDGG FGCRPGSESH AGQIYCCTGF
210 220 230 240 250
LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC YSWWVLASLK
260 270 280 290 300
IIGRLHWIDR EKLRSFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL
310 320 330
LGEEQIKPVS PVFCMPEEVL QRVNVQPELV S
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP53612 | PGTB2_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 339 | Annotation score: | ||
A0A0G2JG79 | A0A0G2JG79_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 205 | Annotation score: | ||
Q6PFA1 | Q6PFA1_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 132 | Annotation score: | ||
A0A0G2JF29 | A0A0G2JF29_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 162 | Annotation score: | ||
Q9JIF6 | Q9JIF6_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 153 | Annotation score: | ||
A0A0G2JDK3 | A0A0G2JDK3_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 149 | Annotation score: | ||
A0A0G2JGU4 | A0A0G2JGU4_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 152 | Annotation score: | ||
A0A0G2JFP7 | A0A0G2JFP7_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 59 | Annotation score: | ||
A0A0G2JGH5 | A0A0G2JGH5_MOUSE | Geranylgeranyl transferase type-2 s... | Rabggtb | 80 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK160162 mRNA Translation: BAE35665.1 |
RefSeqi | NP_001156950.1, NM_001163478.1 NP_001156951.1, NM_001163479.1 NP_035361.2, NM_011231.2 |
Genome annotation databases
Ensembli | ENSMUST00000089950; ENSMUSP00000087396; ENSMUSG00000038975 |
GeneIDi | 19352 |
KEGGi | mmu:19352 |
UCSCi | uc012czt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK160162 mRNA Translation: BAE35665.1 |
RefSeqi | NP_001156950.1, NM_001163478.1 NP_001156951.1, NM_001163479.1 NP_035361.2, NM_011231.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 328878 |
Protocols and materials databases
Antibodypediai | 19716, 68 antibodies from 23 providers |
DNASUi | 19352 |
Genome annotation databases
Ensembli | ENSMUST00000089950; ENSMUSP00000087396; ENSMUSG00000038975 |
GeneIDi | 19352 |
KEGGi | mmu:19352 |
UCSCi | uc012czt.1, mouse |
Organism-specific databases
CTDi | 5876 |
MGIi | MGI:99537, Rabggtb |
VEuPathDBi | HostDB:ENSMUSG00000038975 |
Phylogenomic databases
GeneTreei | ENSGT00950000183128 |
HOGENOMi | CLU_028946_3_0_1 |
OMAi | VKRCQCP |
OrthoDBi | 1042804at2759 |
Miscellaneous databases
BioGRID-ORCSi | 19352, 25 hits in 60 CRISPR screens |
ChiTaRSi | Rabggtb, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038975, Expressed in cumulus cell and 316 other tissues |
Family and domain databases
CDDi | cd02894, GGTase-II, 1 hit |
InterProi | View protein in InterPro IPR001330, PFTB_repeat IPR045089, PGGT1B-like IPR026873, Ptb1 IPR008930, Terpenoid_cyclase/PrenylTrfase |
PANTHERi | PTHR11774, PTHR11774, 1 hit |
Pfami | View protein in Pfam PF00432, Prenyltrans, 5 hits |
SUPFAMi | SSF48239, SSF48239, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TVF4_MOUSE | |
Accessioni | Q3TVF4Primary (citable) accession number: Q3TVF4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | January 19, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |