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Protein

Cyclin-D1-binding protein 1

Gene

Ccndbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity). May be required for hepatocyte proliferation.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-D1-binding protein 1
Alternative name(s):
Grap2 and cyclin-D-interacting protein
Maternal Id-like protein
Stage specific embryonic cDNA-8 protein
Short name:
SSEC-8
Gene namesi
Name:Ccndbp1
Synonyms:Dip1, Gcip, Maid
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109595 Ccndbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003233742 – 356Cyclin-D1-binding protein 1Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3TVC7
MaxQBiQ3TVC7
PaxDbiQ3TVC7
PeptideAtlasiQ3TVC7
PRIDEiQ3TVC7

PTM databases

PhosphoSitePlusiQ3TVC7

Expressioni

Tissue specificityi

Expressed at high levels in brain, intestine, muscle and ovary and at lower levels in heart, kidney, liver, lung, spleen and testis.1 Publication

Developmental stagei

Highly expressed in the unfertilized egg. Expression is reduced at the two cell and blastocyst stages. Expressed in the liver, CNS and dorsal root ganglia throughout organogenesis. Also expressed in the intestine, kidney, lung, nasal cavities and thymus from E13.2 Publications

Inductioni

Expression is induced by partial hepatectomy.1 Publication

Gene expression databases

BgeeiENSMUSG00000023572 Expressed in 289 organ(s), highest expression level in blood
CleanExiMM_CCNDBP1
ExpressionAtlasiQ3TVC7 baseline and differential
GenevisibleiQ3TVC7 MM

Interactioni

Subunit structurei

Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.By similarity

Protein-protein interaction databases

IntActiQ3TVC7, 1 interactor
MINTiQ3TVC7
STRINGi10090.ENSMUSP00000062496

Structurei

3D structure databases

ProteinModelPortaliQ3TVC7
SMRiQ3TVC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 205Required for interaction with CCND1By similarityAdd BLAST204
Regioni2 – 187Interaction with RPLP0By similarityAdd BLAST186
Regioni2 – 181Interaction with TCF3By similarityAdd BLAST180
Regioni147 – 356Interaction with TCF3By similarityAdd BLAST210
Regioni236 – 356Interaction with RPLP0By similarityAdd BLAST121

Sequence similaritiesi

Belongs to the CCNDBP1 family.Curated

Phylogenomic databases

eggNOGiENOG410II9T Eukaryota
ENOG410ZPHZ LUCA
GeneTreeiENSGT00390000018016
HOGENOMiHOG000111444
HOVERGENiHBG107623
InParanoidiQ3TVC7
KOiK21626
OMAiMCHLTVR
OrthoDBiEOG091G0HT3
PhylomeDBiQ3TVC7
TreeFamiTF336444

Family and domain databases

InterProiView protein in InterPro
IPR026907 CCNDBP1
PANTHERiPTHR15492 PTHR15492, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3TVC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSTAAVPF LAPPLEQLRH LAEELRSLLP RVRVGEAQET AEEFNREMFW
60 70 80 90 100
RRLNEAAVKV NGEATVLTTH FSKLPWPSPQ ETQRICEQVR IAIEEIIIVY
110 120 130 140 150
YSLPKDQGIT LRKLVRNAAL DIVDGMAQLL EVLLTAPSQS TENGDLISCN
160 170 180 190 200
SVSVACQQVP EIPKDNKAAA LLMLTKSVDF VKDAHEEMEQ AVEECDPYSG
210 220 230 240 250
LLNDSEDNSD SHSDEDGVLG LPSNRDSYWS EEDQELIIPC LALVRASRAS
260 270 280 290 300
LKKIRILVAE NGKKDEVAQL DDIVDISDEI SPSVDDLVLS IYPPVCHLTV
310 320 330 340 350
RISSAKLVSV LIKALEITKA SHVSPHPGDS WIPLLINAVD HCMNRIKALT

QRAAEL
Length:356
Mass (Da):39,356
Last modified:October 11, 2005 - v1
Checksum:iE112C12AB12B7568
GO
Isoform 2 (identifier: Q3TVC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:309
Mass (Da):34,113
Checksum:i4A7B2E71AFAA5738
GO
Isoform 3 (identifier: Q3TVC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-349: SAKLVSVLIK...DHCMNRIKAL → VNVWTLRGSV...NSCPYACKHS

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):42,543
Checksum:i7040AE6837E7A3CB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J177A0A0R4J177_MOUSE
Cyclin-D1-binding protein 1
Ccndbp1
375Annotation score:

Sequence cautioni

The sequence AAB58118 differs from that shown. Reason: Frameshift at positions 275, 278 and 286.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0320171 – 47Missing in isoform 2. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_032018304 – 349SAKLV…RIKAL → VNVWTLRGSVTLPDYPETVH SLNLELVWQQASPAIALPLC PQRWSNRYTHGHTSFFYVCL GLNSCPYACKHS in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50734 mRNA Translation: AAB58118.1 Frameshift.
AK144883 mRNA Translation: BAE26115.1
AK154285 mRNA Translation: BAE32489.1
AK160205 mRNA Translation: BAE35692.1
AK163150 mRNA Translation: BAE37214.1
AK167345 mRNA Translation: BAE39444.1
AL844548 Genomic DNA No translation available.
BC001984 mRNA Translation: AAH01984.2
BC004673 mRNA Translation: AAH04673.1
BC005802 mRNA Translation: AAH05802.1
CCDSiCCDS38213.1 [Q3TVC7-1]
RefSeqiNP_034891.2, NM_010761.2 [Q3TVC7-1]
UniGeneiMm.7838

Genome annotation databases

EnsembliENSMUST00000060455; ENSMUSP00000062496; ENSMUSG00000023572 [Q3TVC7-1]
ENSMUST00000099489; ENSMUSP00000097088; ENSMUSG00000023572 [Q3TVC7-2]
ENSMUST00000171260; ENSMUSP00000125961; ENSMUSG00000023572 [Q3TVC7-3]
GeneIDi17151
KEGGimmu:17151
UCSCiuc008lxg.1 mouse [Q3TVC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50734 mRNA Translation: AAB58118.1 Frameshift.
AK144883 mRNA Translation: BAE26115.1
AK154285 mRNA Translation: BAE32489.1
AK160205 mRNA Translation: BAE35692.1
AK163150 mRNA Translation: BAE37214.1
AK167345 mRNA Translation: BAE39444.1
AL844548 Genomic DNA No translation available.
BC001984 mRNA Translation: AAH01984.2
BC004673 mRNA Translation: AAH04673.1
BC005802 mRNA Translation: AAH05802.1
CCDSiCCDS38213.1 [Q3TVC7-1]
RefSeqiNP_034891.2, NM_010761.2 [Q3TVC7-1]
UniGeneiMm.7838

3D structure databases

ProteinModelPortaliQ3TVC7
SMRiQ3TVC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TVC7, 1 interactor
MINTiQ3TVC7
STRINGi10090.ENSMUSP00000062496

PTM databases

PhosphoSitePlusiQ3TVC7

Proteomic databases

EPDiQ3TVC7
MaxQBiQ3TVC7
PaxDbiQ3TVC7
PeptideAtlasiQ3TVC7
PRIDEiQ3TVC7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060455; ENSMUSP00000062496; ENSMUSG00000023572 [Q3TVC7-1]
ENSMUST00000099489; ENSMUSP00000097088; ENSMUSG00000023572 [Q3TVC7-2]
ENSMUST00000171260; ENSMUSP00000125961; ENSMUSG00000023572 [Q3TVC7-3]
GeneIDi17151
KEGGimmu:17151
UCSCiuc008lxg.1 mouse [Q3TVC7-1]

Organism-specific databases

CTDi23582
MGIiMGI:109595 Ccndbp1

Phylogenomic databases

eggNOGiENOG410II9T Eukaryota
ENOG410ZPHZ LUCA
GeneTreeiENSGT00390000018016
HOGENOMiHOG000111444
HOVERGENiHBG107623
InParanoidiQ3TVC7
KOiK21626
OMAiMCHLTVR
OrthoDBiEOG091G0HT3
PhylomeDBiQ3TVC7
TreeFamiTF336444

Miscellaneous databases

PROiPR:Q3TVC7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023572 Expressed in 289 organ(s), highest expression level in blood
CleanExiMM_CCNDBP1
ExpressionAtlasiQ3TVC7 baseline and differential
GenevisibleiQ3TVC7 MM

Family and domain databases

InterProiView protein in InterPro
IPR026907 CCNDBP1
PANTHERiPTHR15492 PTHR15492, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCDB1_MOUSE
AccessioniPrimary (citable) accession number: Q3TVC7
Secondary accession number(s): Q3UMI3
, Q61162, Q99JA7, Q99KG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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