UniProtKB - Q3TUL7 (DCA17_MOUSE)
Protein
DDB1- and CUL4-associated factor 17
Gene
Dcaf17
Organism
Mus musculus (Mouse)
Status
Functioni
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: DDB1- and CUL4-associated factor 17 |
Gene namesi | Name:Dcaf17 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923013, Dcaf17 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Note: According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: MGI
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000300119 | 1 – 519 | DDB1- and CUL4-associated factor 17Add BLAST | 519 |
Proteomic databases
EPDi | Q3TUL7 |
PaxDbi | Q3TUL7 |
PRIDEi | Q3TUL7 |
PTM databases
PhosphoSitePlusi | Q3TUL7 |
Expressioni
Tissue specificityi
Ubiquitously expressed in the embryo, with higher expression in brain, liver and skin tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000041966, Expressed in ear vesicle and 264 other tissues |
ExpressionAtlasi | Q3TUL7, baseline and differential |
Genevisiblei | Q3TUL7, MM |
Interactioni
Subunit structurei
Interacts with DDB1, CUL4A and CUL4B.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000120016 |
Miscellaneous databases
RNActi | Q3TUL7, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 510 – 513 | Poly-Glu | 4 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ41, Eukaryota |
GeneTreei | ENSGT00390000012728 |
HOGENOMi | CLU_604033_0_0_1 |
InParanoidi | Q3TUL7 |
OMAi | GGFPWHY |
OrthoDBi | 1292766at2759 |
PhylomeDBi | Q3TUL7 |
TreeFami | TF328801 |
Family and domain databases
InterProi | View protein in InterPro IPR031620, DCAF17 |
PANTHERi | PTHR14815, PTHR14815, 1 hit |
Pfami | View protein in Pfam PF15802, DCAF17, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3TUL7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRTRKANVC RRLSRRALGF YARDAGVVQR TNLGILRALV CQESTKFKNV
60 70 80 90 100
WTTHSKSPIA YERGRIYFDN YRCCVSSVAS EPRKLYEMPK CSKSEKIEDA
110 120 130 140 150
LLWECPVGDI LPDPSDYKSS LIALTAHNWL LRISATTGEV LEKIYLASYC
160 170 180 190 200
KFRYLSWDTP QEVIAVKSAQ NKGSAAARQA GTSPPVLLYL AVFRVLPFSL
210 220 230 240 250
VGILEINKKV FENVTDATLS HGILIVMYSS GLVRLYSFQA IIEQFMQQKL
260 270 280 290 300
DLGCACSQGG TTGTVGEAPF GIPCNVKITD SPPPLFEVSS LENAFQIGGH
310 320 330 340 350
PWHYIITPNK KKQKGVFHIC ALKDNSLAKN GIQEMECCSL ESDWIYFHPD
360 370 380 390 400
ASGRIIHVGP NQVKVLKLSE VENDSSQHQI SEDFVIWAKR EDRKENLITV
410 420 430 440 450
TASGRVVKRN VSLLDDDPEQ ETFKIVDYED ELDLLSVVAV TQIDAEGKAH
460 470 480 490 500
LDFHCNEYGT LLKSIPLVES WDVTYSHEVY FDRDLVLHIE QKPNRVFSCY
510
VYQMVCDPGE EEEAVNRSG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0R0U2 | B0R0U2_MOUSE | DDB1- and CUL4-associated factor 17 | Dcaf17 | 157 | Annotation score: | ||
Z4YK64 | Z4YK64_MOUSE | DDB1- and CUL4-associated factor 17 | Dcaf17 | 505 | Annotation score: | ||
F6YAD1 | F6YAD1_MOUSE | DDB1- and CUL4-associated factor 17 | Dcaf17 | 405 | Annotation score: | ||
F8WIJ2 | F8WIJ2_MOUSE | DDB1- and CUL4-associated factor 17 | Dcaf17 | 156 | Annotation score: | ||
F6XZ79 | F6XZ79_MOUSE | DDB1- and CUL4-associated factor 17 | Dcaf17 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q3TUL7-2) | |||||
Sequence conflicti | 477 | M → T in CAM22154 (PubMed:19468303).Curated | 1 | ||
Sequence conflicti | 504 | V → M in CAM22154 (PubMed:19468303).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027790 | 245 – 286 | FMQQK…PPPLF → THHLHSLKFHLWRTHSRLEA ILGTTSSRLIRRNRKEFFIF VP in isoform 3. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_027791 | 287 – 519 | Missing in isoform 3. 1 PublicationAdd BLAST | 233 | |
Alternative sequenceiVSP_027789 | 474 – 519 | TYSHE…VNRSG → VCIMSGTLSCKGFLYRCHLL DHVHISPDSPVL in isoform 2. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032671 mRNA Translation: BAC27979.1 AK160679 mRNA Translation: BAE35954.1 AL929228 Genomic DNA Translation: CAM22153.1 AL929228 Genomic DNA Translation: CAM22154.1 AL929228 Genomic DNA Translation: CAM22155.1 BC031546 mRNA Translation: AAH31546.1 |
CCDSi | CCDS16111.1 [Q3TUL7-2] CCDS50601.1 [Q3TUL7-1] CCDS50602.1 [Q3TUL7-3] |
RefSeqi | NP_001159452.1, NM_001165980.1 [Q3TUL7-1] NP_001159453.1, NM_001165981.1 [Q3TUL7-1] NP_001159454.1, NM_001165982.1 [Q3TUL7-3] NP_932122.2, NM_198005.2 XP_006500402.1, XM_006500339.3 [Q3TUL7-1] |
Genome annotation databases
Ensembli | ENSMUST00000064141; ENSMUSP00000065624; ENSMUSG00000041966 [Q3TUL7-1] ENSMUST00000112159; ENSMUSP00000107785; ENSMUSG00000041966 [Q3TUL7-3] ENSMUST00000154704; ENSMUSP00000120016; ENSMUSG00000041966 [Q3TUL7-1] |
GeneIDi | 75763 |
KEGGi | mmu:75763 |
UCSCi | uc008kab.2, mouse [Q3TUL7-3] uc008kad.2, mouse [Q3TUL7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032671 mRNA Translation: BAC27979.1 AK160679 mRNA Translation: BAE35954.1 AL929228 Genomic DNA Translation: CAM22153.1 AL929228 Genomic DNA Translation: CAM22154.1 AL929228 Genomic DNA Translation: CAM22155.1 BC031546 mRNA Translation: AAH31546.1 |
CCDSi | CCDS16111.1 [Q3TUL7-2] CCDS50601.1 [Q3TUL7-1] CCDS50602.1 [Q3TUL7-3] |
RefSeqi | NP_001159452.1, NM_001165980.1 [Q3TUL7-1] NP_001159453.1, NM_001165981.1 [Q3TUL7-1] NP_001159454.1, NM_001165982.1 [Q3TUL7-3] NP_932122.2, NM_198005.2 XP_006500402.1, XM_006500339.3 [Q3TUL7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000120016 |
PTM databases
PhosphoSitePlusi | Q3TUL7 |
Proteomic databases
EPDi | Q3TUL7 |
PaxDbi | Q3TUL7 |
PRIDEi | Q3TUL7 |
Protocols and materials databases
Antibodypediai | 65882, 38 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000064141; ENSMUSP00000065624; ENSMUSG00000041966 [Q3TUL7-1] ENSMUST00000112159; ENSMUSP00000107785; ENSMUSG00000041966 [Q3TUL7-3] ENSMUST00000154704; ENSMUSP00000120016; ENSMUSG00000041966 [Q3TUL7-1] |
GeneIDi | 75763 |
KEGGi | mmu:75763 |
UCSCi | uc008kab.2, mouse [Q3TUL7-3] uc008kad.2, mouse [Q3TUL7-1] |
Organism-specific databases
CTDi | 80067 |
MGIi | MGI:1923013, Dcaf17 |
Phylogenomic databases
eggNOGi | ENOG502QQ41, Eukaryota |
GeneTreei | ENSGT00390000012728 |
HOGENOMi | CLU_604033_0_0_1 |
InParanoidi | Q3TUL7 |
OMAi | GGFPWHY |
OrthoDBi | 1292766at2759 |
PhylomeDBi | Q3TUL7 |
TreeFami | TF328801 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 75763, 0 hits in 17 CRISPR screens |
ChiTaRSi | Dcaf17, mouse |
PROi | PR:Q3TUL7 |
RNActi | Q3TUL7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041966, Expressed in ear vesicle and 264 other tissues |
ExpressionAtlasi | Q3TUL7, baseline and differential |
Genevisiblei | Q3TUL7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR031620, DCAF17 |
PANTHERi | PTHR14815, PTHR14815, 1 hit |
Pfami | View protein in Pfam PF15802, DCAF17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCA17_MOUSE | |
Accessioni | Q3TUL7Primary (citable) accession number: Q3TUL7 Secondary accession number(s): A2AUU6, Q8C002, Q8K0F5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways