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Protein

Phosphatidate cytidylyltransferase, mitochondrial

Gene

Tamm41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactori

Mg2+By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 4 (Gpat4), Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 2, mitochondrial (Gpat2)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Agpat3), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (Agpat1), Lysocardiolipin acyltransferase 1 (Lclat1), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (Agpat5), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
  3. Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 1 (Cds1)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase, mitochondrial (EC:2.7.7.41)
Alternative name(s):
CDP-diacylglycerol synthase
Short name:
CDP-DAG synthase
Mitochondrial translocator assembly and maintenance protein 41 homolog
Short name:
TAM41
Gene namesi
Name:Tamm41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916221 Tamm41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000024835525 – 337Phosphatidate cytidylyltransferase, mitochondrialAdd BLAST313

Proteomic databases

EPDiQ3TUH1
MaxQBiQ3TUH1
PaxDbiQ3TUH1
PeptideAtlasiQ3TUH1
PRIDEiQ3TUH1

PTM databases

iPTMnetiQ3TUH1
PhosphoSitePlusiQ3TUH1

Expressioni

Gene expression databases

CleanExiMM_1500001M20RIK

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032461

Family & Domainsi

Sequence similaritiesi

Belongs to the TAM41 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2986 Eukaryota
ENOG410ZNKE LUCA
HOGENOMiHOG000205225
HOVERGENiHBG081975
InParanoidiQ3TUH1
PhylomeDBiQ3TUH1

Family and domain databases

InterProiView protein in InterPro
IPR015222 Tam41
PANTHERiPTHR13619 PTHR13619, 1 hit
PfamiView protein in Pfam
PF09139 Mmp37, 1 hit
PIRSFiPIRSF028840 Mmp37, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TUH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALQALHSSG VGLRRILAHF PEDLSLAFAY GSAVYRQAGP SAHQENPMLD
60 70 80 90 100
LVFTVDDPVA WHAMNLKKNW SHYSFLKLLG PRIISSIQNN YGAGVYFNPL
110 120 130 140 150
IRCDGKLIKY GVISTGTLIE DLLNWNNLYI AGRLQKPVKI VSMNENMALR
160 170 180 190 200
AALDKNLRSA VTTACLMLPE SFSEEDLFIE IAGLSYSGDF RMVIGEEKSK
210 220 230 240 250
VLNIVKPNVG HFRELYESIL QKDPQVVYKM HQGQLEIDKS PEGQFTQLMT
260 270 280 290 300
LPRTLQQQIN HIMDPPGRNR DVEETLLQVA QDPDCGDVVR LAISSIVRPS
310 320 330
SIRQSTKGLF TAGMKKSVIY SSRKLNKMWK GWMSKAS
Length:337
Mass (Da):37,828
Last modified:September 5, 2006 - v2
Checksum:iCBC7BDB1DDFFC093
GO
Isoform 2 (identifier: Q3TUH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-239: DFRMVIGEEK...MHQGQLEIDK → LYSAWWVLHP...CGPAQVFPTS
     240-337: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):26,391
Checksum:iEDA715C47885DABF
GO

Sequence cautioni

The sequence AK005100 differs from that shown. Reason: Frameshift at position 5.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020248189 – 239DFRMV…LEIDK → LYSAWWVLHPSLAGSSWHQP HAGQLFVRKLGAWPQLLGHL GCGPAQVFPTS in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_020249240 – 337Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005100 mRNA No translation available.
AK160774 mRNA Translation: BAE36000.1
CCDSiCCDS20437.1 [Q3TUH1-1]
UniGeneiMm.24937

Genome annotation databases

UCSCiuc009dik.1 mouse [Q3TUH1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTAM41_MOUSE
AccessioniPrimary (citable) accession number: Q3TUH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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