UniProtKB - Q3TUF7 (YETS2_MOUSE)
YEATS domain-containing protein 2
Yeats2
Functioni
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.
By similarityGO - Molecular functioni
- histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- TBP-class protein binding Source: MGI
GO - Biological processi
- histone H3 acetylation Source: MGI
- histone H3-K14 acetylation Source: Ensembl
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell cycle Source: ComplexPortal
- regulation of cell division Source: ComplexPortal
- regulation of embryonic development Source: ComplexPortal
- regulation of histone deacetylation Source: Ensembl
- regulation of tubulin deacetylation Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: YEATS domain-containing protein 2Curated |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2447762, Yeats2 |
VEuPathDBi | HostDB:ENSMUSG00000041215 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- mitotic spindle Source: MGI
Nucleus
- ATAC complex Source: Ensembl
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076367 | 1 – 1407 | YEATS domain-containing protein 2Add BLAST | 1407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 9 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 113 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 118 | PhosphoserineBy similarity | 1 | |
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 157 | PhosphoserineBy similarity | 1 | |
Cross-linki | 189 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 406 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 446 | PhosphoserineBy similarity | 1 | |
Modified residuei | 462 | PhosphoserineBy similarity | 1 | |
Modified residuei | 464 | PhosphoserineBy similarity | 1 | |
Modified residuei | 470 | PhosphoserineBy similarity | 1 | |
Modified residuei | 472 | PhosphoserineCombined sources | 1 | |
Modified residuei | 477 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 486 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 534 | PhosphoserineBy similarity | 1 | |
Cross-linki | 550 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 573 | PhosphoserineBy similarity | 1 | |
Cross-linki | 590 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 625 | PhosphoserineBy similarity | 1 | |
Cross-linki | 647 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 771 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 908 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1095 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 1095 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 1115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1204 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 1207 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1270 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q3TUF7 |
jPOSTi | Q3TUF7 |
MaxQBi | Q3TUF7 |
PaxDbi | Q3TUF7 |
PeptideAtlasi | Q3TUF7 |
PRIDEi | Q3TUF7 |
ProteomicsDBi | 299624 [Q3TUF7-1] 299625 [Q3TUF7-2] 299626 [Q3TUF7-3] |
PTM databases
iPTMneti | Q3TUF7 |
PhosphoSitePlusi | Q3TUF7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041215, Expressed in dorsal pancreas and 260 other tissues |
ExpressionAtlasi | Q3TUF7, baseline and differential |
Genevisiblei | Q3TUF7, MM |
Interactioni
Subunit structurei
Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.
By similarityGO - Molecular functioni
- histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- TBP-class protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 228952, 5 interactors |
ComplexPortali | CPX-1025, GCN5-containing ATAC complex CPX-1029, PCAF-containing ATAC complex |
IntActi | Q3TUF7, 3 interactors |
MINTi | Q3TUF7 |
STRINGi | 10090.ENSMUSP00000111222 |
Miscellaneous databases
RNActi | Q3TUF7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 201 – 346 | YEATSPROSITE-ProRule annotationAdd BLAST | 146 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 196 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 260 – 262 | Histone H3K27cr bindingBy similarity | 3 | |
Regioni | 283 – 285 | Histone H3K27cr bindingBy similarity | 3 | |
Regioni | 462 – 540 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 791 – 833 | DisorderedSequence analysisAdd BLAST | 43 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 54 – 80 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 117 – 152 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 153 – 196 | Basic and acidic residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 479 – 496 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 508 – 540 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 815 – 833 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000156789 |
HOGENOMi | CLU_258270_0_0_1 |
InParanoidi | Q3TUF7 |
PhylomeDBi | Q3TUF7 |
TreeFami | TF314586 |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
PANTHERi | PTHR23195, PTHR23195, 1 hit |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ESSARDAAVQ KIETIIKEQF
60 70 80 90 100
ALEMKNKEHE IDVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGLK
110 120 130 140 150
TFDPMAFNHP AIKKFLESPS RSSSPTNQRS ETPSANHSES DSLSQHNDFL
160 170 180 190 200
SDKDNNSNVD VEERPPSTGE QRPSRKAGRD TSSISGSHKR ELRNADLTGD
210 220 230 240 250
ETSRLFVKKT IVVGNVSKYI PPDKREENDQ STHKWMVYVR GSRREPSINH
260 270 280 290 300
FVKKVWFFLH PSYKPNDLVE VREPPFHLTR RGWGEFPVRV QVHFKDSQNK
310 320 330 340 350
RIDIIHNLKL DRTYTGLQTL GAETVVDVEL HRHSLGEDSV YPQSSESDVC
360 370 380 390 400
DAPPPTLTLP AAVKASAVAQ SPEPAAAAPV GEGFPETTEA ERHSTFYSLP
410 420 430 440 450
SSLERTPTKV TTAQKVTFSS HGNSAFQPIA SSCKIVPQSQ VPNPESPGKS
460 470 480 490 500
FQPITMSCKI VSGSPISTPS PSPLPRTPTS TPVHLKQGTA SSGVSNPHVI
510 520 530 540 550
VDKPGQVIGA STPSTGSPTS KLPVASQASQ GTGSPIPKIH GSSFLTSTVK
560 570 580 590 600
QEESLFASMP PLCPIGSHPK VQSPKAVTGG LGAFTKVIIK QEPGEAPHVS
610 620 630 640 650
TTGAASQSAF PQYVTVKGGH MIAVSPQKQV ISAGEGTTQS PKIAPSKVVG
660 670 680 690 700
VPVGSALPST VKQAVAISSG QILVAKASSS VTKAVGPKQV VTQGVAKAIV
710 720 730 740 750
SGGGGTIVAQ PVQTLTKTQV TAAGPQKSGS QGSVMATLQL PATNLANLAN
760 770 780 790 800
LPPGTKLYLT TNSKNPSGKG KLLLIPQGAI LRATNNANLQ SGSAAAGGSG
810 820 830 840 850
SSGAGGGSGG GGGSGAGGTP STSGPGGGPQ HLTYTSYILK QTPQGTFLVG
860 870 880 890 900
QPSPQTPGKQ LTTASVVQGT LGVSSSSAQG QQTLKVISGQ KTTLFTQAAT
910 920 930 940 950
AGQASLLKLP DNTLKSVPAA PQLAKPGTTM LRVAGGVITA APSPAVAFSA
960 970 980 990 1000
NGAVHQSEGS TPVSSSVGSI IKTPGQPQVC VSQATMATCK GPAAVAGTAA
1010 1020 1030 1040 1050
SLVSAPSSIS GKATVSGLLK VHSAQSSPQQ AVLTIPSQLK PLSINTSGGV
1060 1070 1080 1090 1100
QTVLMPVNKV VQSFSTSKLP TTVLPISVPN QAAPSSAPVA IAKVKTEPET
1110 1120 1130 1140 1150
PGPNCISQEN QVAVKTEESS ELSNYVIKVD HLETIQQLLT AVVKKIPLIT
1160 1170 1180 1190 1200
AKGDDASCFS AKSLEQYYGW NIGKRRAAEW QRAMTVRKVL QEILEKNPRF
1210 1220 1230 1240 1250
HHLTPLKTKH IAHWCRCHGY TPPDPESLRH DGDSIEDVLT QIDSEPECLS
1260 1270 1280 1290 1300
SFSTADDLCR KLEDLQQFQK REPENEEEVD ILSLSEPLKT NIKKEQEEKQ
1310 1320 1330 1340 1350
EEMRFYLPPT PGSGFVGDIT QKIGITLQPV ALHRNMYASV VEDMILKATE
1360 1370 1380 1390 1400
QLVSDILRQA LAVGYQTASP NRIPKEITVS NIHQAICNIP FLDFLTNKHM
GRLNEDQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A338P689 | A0A338P689_MOUSE | YEATS domain-containing protein 2 | Yeats2 | 844 | Annotation score: | ||
A0A338P697 | A0A338P697_MOUSE | YEATS domain-containing protein 2 | Yeats2 | 1,369 | Annotation score: | ||
A0A338P6P2 | A0A338P6P2_MOUSE | YEATS domain-containing protein 2 | Yeats2 | 218 | Annotation score: | ||
A0A338P7J1 | A0A338P7J1_MOUSE | YEATS domain-containing protein 2 | Yeats2 | 142 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 310 | L → V in BAC65745 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 1162 | K → E in BAE36014 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1294 | K → R in BAE36014 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017006 | 1 – 53 | Missing in isoform 3. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_017007 | 1291 – 1305 | NIKKE…EEMRF → SASVVNLLFVCSKET in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_017008 | 1306 – 1407 | Missing in isoform 2. 1 PublicationAdd BLAST | 102 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK160791 mRNA Translation: BAE36014.1 AK122463 Transcribed RNA Translation: BAC65745.3 Sequence problems. BC042768 mRNA Translation: AAH42768.1 BC057045 mRNA Translation: AAH57045.1 Different initiation. |
CCDSi | CCDS28043.1 [Q3TUF7-3] CCDS49790.1 [Q3TUF7-1] |
RefSeqi | NP_001028409.2, NM_001033237.2 [Q3TUF7-3] NP_001139402.1, NM_001145930.1 [Q3TUF7-1] XP_006521965.1, XM_006521902.3 [Q3TUF7-1] |
Genome annotation databases
Ensembli | ENSMUST00000090052; ENSMUSP00000087506; ENSMUSG00000041215 [Q3TUF7-3] ENSMUST00000115560; ENSMUSP00000111222; ENSMUSG00000041215 [Q3TUF7-1] |
GeneIDi | 208146 |
KEGGi | mmu:208146 |
UCSCi | uc007ypj.2, mouse [Q3TUF7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK160791 mRNA Translation: BAE36014.1 AK122463 Transcribed RNA Translation: BAC65745.3 Sequence problems. BC042768 mRNA Translation: AAH42768.1 BC057045 mRNA Translation: AAH57045.1 Different initiation. |
CCDSi | CCDS28043.1 [Q3TUF7-3] CCDS49790.1 [Q3TUF7-1] |
RefSeqi | NP_001028409.2, NM_001033237.2 [Q3TUF7-3] NP_001139402.1, NM_001145930.1 [Q3TUF7-1] XP_006521965.1, XM_006521902.3 [Q3TUF7-1] |
3D structure databases
SMRi | Q3TUF7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228952, 5 interactors |
ComplexPortali | CPX-1025, GCN5-containing ATAC complex CPX-1029, PCAF-containing ATAC complex |
IntActi | Q3TUF7, 3 interactors |
MINTi | Q3TUF7 |
STRINGi | 10090.ENSMUSP00000111222 |
PTM databases
iPTMneti | Q3TUF7 |
PhosphoSitePlusi | Q3TUF7 |
Proteomic databases
EPDi | Q3TUF7 |
jPOSTi | Q3TUF7 |
MaxQBi | Q3TUF7 |
PaxDbi | Q3TUF7 |
PeptideAtlasi | Q3TUF7 |
PRIDEi | Q3TUF7 |
ProteomicsDBi | 299624 [Q3TUF7-1] 299625 [Q3TUF7-2] 299626 [Q3TUF7-3] |
Protocols and materials databases
Antibodypediai | 50874, 88 antibodies from 26 providers |
Genome annotation databases
Ensembli | ENSMUST00000090052; ENSMUSP00000087506; ENSMUSG00000041215 [Q3TUF7-3] ENSMUST00000115560; ENSMUSP00000111222; ENSMUSG00000041215 [Q3TUF7-1] |
GeneIDi | 208146 |
KEGGi | mmu:208146 |
UCSCi | uc007ypj.2, mouse [Q3TUF7-1] |
Organism-specific databases
CTDi | 55689 |
MGIi | MGI:2447762, Yeats2 |
VEuPathDBi | HostDB:ENSMUSG00000041215 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000156789 |
HOGENOMi | CLU_258270_0_0_1 |
InParanoidi | Q3TUF7 |
PhylomeDBi | Q3TUF7 |
TreeFami | TF314586 |
Miscellaneous databases
BioGRID-ORCSi | 208146, 18 hits in 66 CRISPR screens |
ChiTaRSi | Yeats2, mouse |
PROi | PR:Q3TUF7 |
RNActi | Q3TUF7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041215, Expressed in dorsal pancreas and 260 other tissues |
ExpressionAtlasi | Q3TUF7, baseline and differential |
Genevisiblei | Q3TUF7, MM |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
PANTHERi | PTHR23195, PTHR23195, 1 hit |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YETS2_MOUSE | |
Accessioni | Q3TUF7Primary (citable) accession number: Q3TUF7 Secondary accession number(s): Q6PGF8, Q80TI2, Q8CG86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot