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Entry version 119 (16 Oct 2019)
Sequence version 2 (10 Jan 2006)
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Protein

YEATS domain-containing protein 2

Gene

Yeats2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
YEATS domain-containing protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Yeats2Imported
Synonyms:Kiaa11971 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2447762 Yeats2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763671 – 1407YEATS domain-containing protein 2Add BLAST1407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118PhosphoserineBy similarity1
Modified residuei120PhosphoserineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei406PhosphothreonineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei464PhosphoserineBy similarity1
Modified residuei470PhosphoserineBy similarity1
Modified residuei472PhosphoserineCombined sources1
Modified residuei477PhosphothreonineBy similarity1
Cross-linki486Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei534PhosphoserineBy similarity1
Cross-linki550Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei573PhosphoserineBy similarity1
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei625PhosphoserineBy similarity1
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki771Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1095Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1095Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki1115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1204PhosphothreonineBy similarity1
Cross-linki1207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1270Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3TUF7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TUF7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TUF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TUF7

PeptideAtlas

More...
PeptideAtlasi
Q3TUF7

PRoteomics IDEntifications database

More...
PRIDEi
Q3TUF7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TUF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TUF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041215 Expressed in 237 organ(s), highest expression level in dorsal pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3TUF7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TUF7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228952, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1025 GCN5-containing ATAC complex
CPX-1029 PCAF-containing ATAC complex

Protein interaction database and analysis system

More...
IntActi
Q3TUF7, 3 interactors

Molecular INTeraction database

More...
MINTi
Q3TUF7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000111222

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TUF7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini208 – 318YEATSPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni260 – 262Histone H3K27cr bindingBy similarity3
Regioni283 – 285Histone H3K27cr bindingBy similarity3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili54 – 80Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi792 – 828Gly-richAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The YEATS domain specifically recognizes and binds crotonylated histones.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3149 Eukaryota
COG5033 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156789

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155538

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TUF7

Database of Orthologous Groups

More...
OrthoDBi
1482359at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TUF7

TreeFam database of animal gene trees

More...
TreeFami
TF314586

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1970, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038704 YEAST_sf
IPR005033 YEATS

The PANTHER Classification System

More...
PANTHERi
PTHR23195 PTHR23195, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03366 YEATS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51037 YEATS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3TUF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ESSARDAAVQ KIETIIKEQF
60 70 80 90 100
ALEMKNKEHE IDVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGLK
110 120 130 140 150
TFDPMAFNHP AIKKFLESPS RSSSPTNQRS ETPSANHSES DSLSQHNDFL
160 170 180 190 200
SDKDNNSNVD VEERPPSTGE QRPSRKAGRD TSSISGSHKR ELRNADLTGD
210 220 230 240 250
ETSRLFVKKT IVVGNVSKYI PPDKREENDQ STHKWMVYVR GSRREPSINH
260 270 280 290 300
FVKKVWFFLH PSYKPNDLVE VREPPFHLTR RGWGEFPVRV QVHFKDSQNK
310 320 330 340 350
RIDIIHNLKL DRTYTGLQTL GAETVVDVEL HRHSLGEDSV YPQSSESDVC
360 370 380 390 400
DAPPPTLTLP AAVKASAVAQ SPEPAAAAPV GEGFPETTEA ERHSTFYSLP
410 420 430 440 450
SSLERTPTKV TTAQKVTFSS HGNSAFQPIA SSCKIVPQSQ VPNPESPGKS
460 470 480 490 500
FQPITMSCKI VSGSPISTPS PSPLPRTPTS TPVHLKQGTA SSGVSNPHVI
510 520 530 540 550
VDKPGQVIGA STPSTGSPTS KLPVASQASQ GTGSPIPKIH GSSFLTSTVK
560 570 580 590 600
QEESLFASMP PLCPIGSHPK VQSPKAVTGG LGAFTKVIIK QEPGEAPHVS
610 620 630 640 650
TTGAASQSAF PQYVTVKGGH MIAVSPQKQV ISAGEGTTQS PKIAPSKVVG
660 670 680 690 700
VPVGSALPST VKQAVAISSG QILVAKASSS VTKAVGPKQV VTQGVAKAIV
710 720 730 740 750
SGGGGTIVAQ PVQTLTKTQV TAAGPQKSGS QGSVMATLQL PATNLANLAN
760 770 780 790 800
LPPGTKLYLT TNSKNPSGKG KLLLIPQGAI LRATNNANLQ SGSAAAGGSG
810 820 830 840 850
SSGAGGGSGG GGGSGAGGTP STSGPGGGPQ HLTYTSYILK QTPQGTFLVG
860 870 880 890 900
QPSPQTPGKQ LTTASVVQGT LGVSSSSAQG QQTLKVISGQ KTTLFTQAAT
910 920 930 940 950
AGQASLLKLP DNTLKSVPAA PQLAKPGTTM LRVAGGVITA APSPAVAFSA
960 970 980 990 1000
NGAVHQSEGS TPVSSSVGSI IKTPGQPQVC VSQATMATCK GPAAVAGTAA
1010 1020 1030 1040 1050
SLVSAPSSIS GKATVSGLLK VHSAQSSPQQ AVLTIPSQLK PLSINTSGGV
1060 1070 1080 1090 1100
QTVLMPVNKV VQSFSTSKLP TTVLPISVPN QAAPSSAPVA IAKVKTEPET
1110 1120 1130 1140 1150
PGPNCISQEN QVAVKTEESS ELSNYVIKVD HLETIQQLLT AVVKKIPLIT
1160 1170 1180 1190 1200
AKGDDASCFS AKSLEQYYGW NIGKRRAAEW QRAMTVRKVL QEILEKNPRF
1210 1220 1230 1240 1250
HHLTPLKTKH IAHWCRCHGY TPPDPESLRH DGDSIEDVLT QIDSEPECLS
1260 1270 1280 1290 1300
SFSTADDLCR KLEDLQQFQK REPENEEEVD ILSLSEPLKT NIKKEQEEKQ
1310 1320 1330 1340 1350
EEMRFYLPPT PGSGFVGDIT QKIGITLQPV ALHRNMYASV VEDMILKATE
1360 1370 1380 1390 1400
QLVSDILRQA LAVGYQTASP NRIPKEITVS NIHQAICNIP FLDFLTNKHM

GRLNEDQ
Length:1,407
Mass (Da):148,950
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5530016D1846E2E
GO
Isoform 2 (identifier: Q3TUF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1305: NIKKEQEEKQEEMRF → SASVVNLLFVCSKET
     1306-1407: Missing.

Note: No experimental confirmation available.
Show »
Length:1,305
Mass (Da):137,310
Checksum:i3A83B91FCB81F47A
GO
Isoform 3 (identifier: Q3TUF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:1,354
Mass (Da):142,996
Checksum:i0B5FCE3250F4E6CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P689A0A338P689_MOUSE
YEATS domain-containing protein 2
Yeats2
844Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P697A0A338P697_MOUSE
YEATS domain-containing protein 2
Yeats2
1,369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6P2A0A338P6P2_MOUSE
YEATS domain-containing protein 2
Yeats2
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P7J1A0A338P7J1_MOUSE
YEATS domain-containing protein 2
Yeats2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH57045 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65745 differs from that shown. The sequence differs from that shown because it is derived from pre-RNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti310L → V in BAC65745 (PubMed:12693553).Curated1
Sequence conflicti1162K → E in BAE36014 (PubMed:16141072).Curated1
Sequence conflicti1294K → R in BAE36014 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0170061 – 53Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0170071291 – 1305NIKKE…EEMRF → SASVVNLLFVCSKET in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0170081306 – 1407Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK160791 mRNA Translation: BAE36014.1
AK122463 Transcribed RNA Translation: BAC65745.3 Sequence problems.
BC042768 mRNA Translation: AAH42768.1
BC057045 mRNA Translation: AAH57045.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS28043.1 [Q3TUF7-3]
CCDS49790.1 [Q3TUF7-1]

NCBI Reference Sequences

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RefSeqi
NP_001028409.2, NM_001033237.2 [Q3TUF7-3]
NP_001139402.1, NM_001145930.1 [Q3TUF7-1]
XP_006521965.1, XM_006521902.3 [Q3TUF7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000090052; ENSMUSP00000087506; ENSMUSG00000041215 [Q3TUF7-3]
ENSMUST00000115560; ENSMUSP00000111222; ENSMUSG00000041215 [Q3TUF7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
208146

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:208146

UCSC genome browser

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UCSCi
uc007ypj.2 mouse [Q3TUF7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160791 mRNA Translation: BAE36014.1
AK122463 Transcribed RNA Translation: BAC65745.3 Sequence problems.
BC042768 mRNA Translation: AAH42768.1
BC057045 mRNA Translation: AAH57045.1 Different initiation.
CCDSiCCDS28043.1 [Q3TUF7-3]
CCDS49790.1 [Q3TUF7-1]
RefSeqiNP_001028409.2, NM_001033237.2 [Q3TUF7-3]
NP_001139402.1, NM_001145930.1 [Q3TUF7-1]
XP_006521965.1, XM_006521902.3 [Q3TUF7-1]

3D structure databases

SMRiQ3TUF7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi228952, 3 interactors
ComplexPortaliCPX-1025 GCN5-containing ATAC complex
CPX-1029 PCAF-containing ATAC complex
IntActiQ3TUF7, 3 interactors
MINTiQ3TUF7
STRINGi10090.ENSMUSP00000111222

PTM databases

iPTMnetiQ3TUF7
PhosphoSitePlusiQ3TUF7

Proteomic databases

EPDiQ3TUF7
jPOSTiQ3TUF7
MaxQBiQ3TUF7
PaxDbiQ3TUF7
PeptideAtlasiQ3TUF7
PRIDEiQ3TUF7

Genome annotation databases

EnsembliENSMUST00000090052; ENSMUSP00000087506; ENSMUSG00000041215 [Q3TUF7-3]
ENSMUST00000115560; ENSMUSP00000111222; ENSMUSG00000041215 [Q3TUF7-1]
GeneIDi208146
KEGGimmu:208146
UCSCiuc007ypj.2 mouse [Q3TUF7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55689
MGIiMGI:2447762 Yeats2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3149 Eukaryota
COG5033 LUCA
GeneTreeiENSGT00940000156789
HOGENOMiHOG000155538
InParanoidiQ3TUF7
OrthoDBi1482359at2759
PhylomeDBiQ3TUF7
TreeFamiTF314586

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Yeats2 mouse

Protein Ontology

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PROi
PR:Q3TUF7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041215 Expressed in 237 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ3TUF7 baseline and differential
GenevisibleiQ3TUF7 MM

Family and domain databases

Gene3Di2.60.40.1970, 1 hit
InterProiView protein in InterPro
IPR038704 YEAST_sf
IPR005033 YEATS
PANTHERiPTHR23195 PTHR23195, 1 hit
PfamiView protein in Pfam
PF03366 YEATS, 1 hit
PROSITEiView protein in PROSITE
PS51037 YEATS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYETS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TUF7
Secondary accession number(s): Q6PGF8, Q80TI2, Q8CG86
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 16, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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