We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q3TU20 (Q3TU20_MOUSE)
Protein
Angiotensin-converting enzyme
Gene
Ace
Organism
Mus musculus (Mouse)
Status
Functioni
Cofactori
Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation
GO - Molecular functioni
- bradykinin receptor binding Source: Ensembl
- carboxypeptidase activity Source: UniProtKB-KW
- chloride ion binding Source: Ensembl
- endopeptidase activity Source: Ensembl
- heterocyclic compound binding Source: Ensembl
- metallopeptidase activity Source: UniProtKB-KW
- mitogen-activated protein kinase binding Source: Ensembl
- mitogen-activated protein kinase kinase binding Source: Ensembl
- peptidyl-dipeptidase activity Source: Ensembl
- tripeptidyl-peptidase activity Source: Ensembl
- zinc ion binding Source: Ensembl
GO - Biological processi
- aging Source: Ensembl
- amyloid-beta metabolic process Source: Ensembl
- angiogenesis involved in coronary vascular morphogenesis Source: Ensembl
- animal organ regeneration Source: Ensembl
- arachidonic acid secretion Source: Ensembl
- bradykinin catabolic process Source: Ensembl
- brain development Source: Ensembl
- cellular response to aldosterone Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- eating behavior Source: Ensembl
- embryo development ending in birth or egg hatching Source: Ensembl
- female pregnancy Source: Ensembl
- hormone catabolic process Source: Ensembl
- kidney development Source: Ensembl
- lung alveolus development Source: Ensembl
- male gonad development Source: Ensembl
- negative regulation of calcium ion import Source: Ensembl
- negative regulation of glucose import Source: Ensembl
- negative regulation of renal sodium excretion Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of neurogenesis Source: Ensembl
- positive regulation of systemic arterial blood pressure Source: Ensembl
- positive regulation of vasoconstriction Source: Ensembl
- regulation of angiotensin metabolic process Source: Ensembl
- regulation of smooth muscle cell migration Source: Ensembl
- regulation of systemic arterial blood pressure by renin-angiotensin Source: Ensembl
- response to dexamethasone Source: Ensembl
- response to hypoxia Source: Ensembl
- response to laminar fluid shear stress Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to nutrient levels Source: Ensembl
- response to thyroid hormone Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- sensory perception of pain Source: Ensembl
- vasoconstriction Source: Ensembl
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Protein family/group databases
MEROPSi | M02.004 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AceImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:87874, Ace |
VEuPathDBi | HostDB:ENSMUSG00000020681 |
Subcellular locationi
Endosome
- endosome Source: Ensembl
Extracellular region or secreted
- extracellular exosome Source: Ensembl
Lysosome
- lysosome Source: Ensembl
Plasma Membrane
- basal plasma membrane Source: Ensembl
- brush border membrane Source: Ensembl
- external side of plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
- sperm midpiece Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1265 – 1286 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_5014309162 | 35 – 1312 | Angiotensin-converting enzymeSequence analysisAdd BLAST | 1278 |
Keywords - PTMi
GlycoproteinUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000020681, Expressed in jejunum and 246 other tissues |
Interactioni
GO - Molecular functioni
- bradykinin receptor binding Source: Ensembl
- mitogen-activated protein kinase binding Source: Ensembl
- mitogen-activated protein kinase kinase binding Source: Ensembl
Structurei
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 658 – 678 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | PKHLHTI |
OrthoDBi | 422699at2759 |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
i Sequence
Sequence statusi: Complete.
Q3TU20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAASGQRGR WPLSPPLLML SLLVLLLQPS PAPALDPGLQ PGNFSPDEAG
60 70 80 90 100
AQLFAESYNS SAEVVMFQST VASWAHDTNI TEENARRQEE AALVSQEFAE
110 120 130 140 150
VWGKKAKELY ESIWQNFTDS KLRRIIGSIR TLGPANLPLA QRQQYNSLLS
160 170 180 190 200
NMSRIYSTGK VCFPNKTATC WSLDPELTNI LASSRSYAKL LFAWEGWHDA
210 220 230 240 250
VGIPLKPLYQ DFTAISNEAY RQDDFSDTGA FWRSWYESPS FEESLEHIYH
260 270 280 290 300
QLEPLYLNLH AYVRRALHRR YGDKYVNLRG PIPAHLLGDM WAQSWENIYD
310 320 330 340 350
MVVPFPDKPN LDVTSTMVQK GWNATHMFRV SEEFFTSLGL SPMPPEFWAE
360 370 380 390 400
SMLEKPTDGR EVVCHASAWD FYNRKDFRIK QCTRVTMEQL ATVHHEMGHV
410 420 430 440 450
QYYLQYKDLH VSLRRGANPG FHEAIGDVLA LSVSTPAHLH KIGLLDHVTN
460 470 480 490 500
DIESDINYLL KMALEKIAFL PFGYLVDQWR WGVFSGRTPP SRYNFDWWYL
510 520 530 540 550
RTKYQGICPP VARNETHFDA GAKFHIPNVT PYIRYFVSFV LQFQFHQALC
560 570 580 590 600
KEAGHQGPLH QCDIYQSAQA GAKLKQVLQA GCSRPWQEVL KDLVGSDALD
610 620 630 640 650
AKALLEYFQP VSQWLEEQNQ RNGEVLGWPE NQWRPPLPDN YPEGIDLETD
660 670 680 690 700
EAKADRFVEE YDRTAQVLLN EYAEANWQYN TNITIEGSKI LLEKSTEVSN
710 720 730 740 750
HTLKYGTRAK TFDVSNFQNS SIKRIIKKLQ NLDRAVLPPK ELEEYNQILL
760 770 780 790 800
DMETTYSLSN ICYTNGTCMP LEPDLTNMMA TSRKYEELLW AWKSWRDKVG
810 820 830 840 850
RAILPFFPKY VEFSNKIAKL NGYTDAGDSW RSLYESDNLE QDLEKLYQEL
860 870 880 890 900
QPLYLNLHAY VRRSLHRHYG SEYINLDGPI PAHLLGNMWA QTWSNIYDLV
910 920 930 940 950
APFPSAPNID ATEAMIKQGW TPRRIFKEAD NFFTSLGLLP VPPEFWNKSM
960 970 980 990 1000
LEKPTDGREV VCHPSAWDFY NGKDFRIKQC TSVNMEDLVI AHHEMGHIQY
1010 1020 1030 1040 1050
FMQYKDLPVT FREGANPGFH EAIGDIMALS VSTPKHLYSL NLLSTEGSGY
1060 1070 1080 1090 1100
EYDINFLMKM ALDKIAFIPF SYLIDQWRWR VFDGSITKEN YNQEWWSLRL
1110 1120 1130 1140 1150
KYQGLCPPVP RSQGDFDPGS KFHVPANVPY VRYFVSFIIQ FQFHEALCRA
1160 1170 1180 1190 1200
AGHTGPLHKC DIYQSKEAGK LLADAMKLGY SKPWPEAMKL ITGQPNMSAS
1210 1220 1230 1240 1250
AMMNYFKPLT EWLVTENRRH GETLGWPEYN WAPNTARAEG STAESNRVNF
1260 1270 1280 1290 1300
LGLYLEPQQA RVGQWVLLFL GVALLVATVG LAHRLYNIRN HHSLRRPHRG
1310
PQFGSEVELR HS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110362 mRNA Translation: AAI10363.1 AK161020 mRNA Translation: BAE36151.1 |
RefSeqi | NP_001268748.1, NM_001281819.1 NP_997507.1, NM_207624.5 |
Genome annotation databases
GeneIDi | 11421 |
KEGGi | mmu:11421 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110362 mRNA Translation: AAI10363.1 AK161020 mRNA Translation: BAE36151.1 |
RefSeqi | NP_001268748.1, NM_001281819.1 NP_997507.1, NM_207624.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M02.004 |
Protocols and materials databases
Antibodypediai | 31288, 867 antibodies from 42 providers |
DNASUi | 11421 |
Genome annotation databases
GeneIDi | 11421 |
KEGGi | mmu:11421 |
Organism-specific databases
CTDi | 1636 |
MGIi | MGI:87874, Ace |
VEuPathDBi | HostDB:ENSMUSG00000020681 |
Phylogenomic databases
OMAi | PKHLHTI |
OrthoDBi | 422699at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11421, 2 hits in 65 CRISPR screens |
ChiTaRSi | Ace, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020681, Expressed in jejunum and 246 other tissues |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TU20_MOUSE | |
Accessioni | Q3TU20Primary (citable) accession number: Q3TU20 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | January 19, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |