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Entry version 124 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Keratin, type II cytoskeletal 2 epidermal

Gene

Krt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably contributes to terminal cornification (By similarity).

Associated with keratinocyte activation, proliferation and keratinization (By similarity).

Plays a role in the establishment of the epidermal barrier on plantar skin (PubMed:26603179).

By similarity1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei450StutterSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6805567, Keratinization
R-MMU-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type II cytoskeletal 2 epidermal
Alternative name(s):
Cytokeratin-2e
Short name:
CK-2e
Epithelial keratin-2e
Keratin-2 epidermis
Keratin-2e
Short name:
K2e
Type-II keratin Kb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Krt2Imported
Synonyms:K2e, Krt2-17Imported, Krt2aBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96699, Krt2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Krt2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth. Hyperkeratoses and shedding of the outer layers of the epidermis (molting) are observed in later weeks.

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and display no differences in size and body weight. Show acanthosis, hyperkeratosis and scaling of the stratum corneum in plantar skin. Show no epidermal aberrations of the footpads. Double knockout mice of KRT2 and KRT10 are viable and display no differences in size and body weight. Show a more severe plantar epidermis phenotype as in single KRT2 knockout mice.1 Publication

Keywords - Diseasei

Disease variant, Ichthyosis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002837631 – 707Keratin, type II cytoskeletal 2 epidermalAdd BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22Asymmetric dimethylarginineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei52Omega-N-methylarginineCombined sources1
Modified residuei64PhosphoserineBy similarity1
Modified residuei555Omega-N-methylarginineCombined sources1
Modified residuei593Omega-N-methylarginineCombined sources1
Modified residuei607Omega-N-methylarginineBy similarity1
Modified residuei675Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3922

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TTY5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TTY5

PRoteomics IDEntifications database

More...
PRIDEi
Q3TTY5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269145

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TTY5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TTY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in the suprabasal layers of the plantar epidermis outside of the footpads (at protein level) (PubMed:26603179). Expressed mainly in the middle spinous and granular cells of the epidermis of adult tail, nipple and footsole skin. Also found in ear.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Induction occurs during the first 2 weeks after birth, being first observed in the epidermis of tail then the footpad and later in the ear.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000064201, Expressed in ear and 75 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TTY5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins. Associates with KRT10.

Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201033, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q3TTY5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023712

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3TTY5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TTY5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini199 – 512IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 198HeadSequence analysisAdd BLAST198
Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni29 – 59DisorderedSequence analysisAdd BLAST31
Regioni199 – 234Coil 1ASequence analysisAdd BLAST36
Regioni235 – 253Linker 1Sequence analysisAdd BLAST19
Regioni254 – 345Coil 1BSequence analysisAdd BLAST92
Regioni346 – 369Linker 12Sequence analysisAdd BLAST24
Regioni370 – 508Coil 2Sequence analysisAdd BLAST139
Regioni509 – 707TailSequence analysisAdd BLAST199
Regioni531 – 707DisorderedSequence analysisAdd BLAST177

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 46Polar residuesSequence analysisAdd BLAST18
Compositional biasi531 – 548Polar residuesSequence analysisAdd BLAST18
Compositional biasi565 – 586Polar residuesSequence analysisAdd BLAST22
Compositional biasi645 – 693Polar residuesSequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTM6, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162573

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TTY5

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDYERHV

Database of Orthologous Groups

More...
OrthoDBi
824246at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317854

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR032444, Keratin_2_head
IPR003054, Keratin_II

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038, Filament, 1 hit
PF16208, Keratin_2_head, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01276, TYPE2KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3TTY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCQISCRSR RGGGGGGGGG FRGFSSGSAV VSGGSRRSNT SFSCISRHGG
60 70 80 90 100
GRGGSGGGGF GSQSLVGLGG YKSISSSVAG NSGGYGGSSF GGSSGFGGGR
110 120 130 140 150
GFGGGQGFGG SGGFGGGSGF GGGQGFGGGS RFGGGSGFGG GGFGGGSFGG
160 170 180 190 200
GRFGGGPGGF GGPGGFPGGG IHEVSVNQSL LQPLDVKVDP EIQNVKSQER
210 220 230 240 250
EQIKTLNNKF ASFIDKVRFL EQQNQVLRTK WELLQQLDVG SRTTNLDPIF
260 270 280 290 300
QAYIGMLKKQ VDRLSAERTS QESELNNMQD LVEDFKKKYE DEINKRTSAE
310 320 330 340 350
NDFVTIKKDV DSCYMDKTEL QARLDILAQE VNFLRTLYDA ELSQLQQDVT
360 370 380 390 400
DTNVILSMDN NRNLDLDSII AEVQNQYEMI AHKSKAESEE LYHSKYEELQ
410 420 430 440 450
VTAVKHGDSL KEIKMEISEL NRTIQRLQGE ISHVKKQCKG VQDSIADAEQ
460 470 480 490 500
RGEHAIKDAR GKLTDLEEAL QQCREDLARL LRDYQELMNT KLSLDVEIAT
510 520 530 540 550
YRKLLEGEEC RMSGDFSDNV SVSITSSTIS SSVASKTGFG SGGQSSGGRG
560 570 580 590 600
SYGGRGGGGG GGSTYGSGGR SSGSRGSGSG SGGGGYSSGG GSRGGSGGGY
610 620 630 640 650
GSGGGSRGGS GGGYGSGGGS GSGGGYSSGG GSRGGSGGGG VSSGGGSRGG
660 670 680 690 700
SSSGGGSRGG SSSGGGGYSS GGGSRGGSSS GGAGSSSEKG GSGSGEGCGS

GVTFSFR
Length:707
Mass (Da):70,923
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i464D375DCBA90EF4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti238 – 246DVGSRTTNL → ACRQPHHKP in CAA52788 (PubMed:7508961).Curated9
Sequence conflicti361N → T in CAA52788 (PubMed:7508961).Curated1
Sequence conflicti439K → I in CAA52788 (PubMed:7508961).Curated1
Sequence conflicti451R → H in CAA52788 (PubMed:7508961).Curated1
Sequence conflicti533V → M in CAA52788 (PubMed:7508961).Curated1
Sequence conflicti562Missing in AAI20486 (PubMed:15489334).Curated1
Sequence conflicti564T → S in CAA52788 (PubMed:7508961).Curated1
Sequence conflicti625G → GG in AAI20486 (PubMed:15489334).Curated1
Sequence conflicti641V → A in CAA52788 (PubMed:7508961).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti500T → P in IBS. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74784 mRNA Translation: CAA52788.1
AK132476 mRNA Translation: BAE21186.1
AK161078 mRNA Translation: BAE36187.1
AK161098 mRNA Translation: BAE36194.1
BC120485 mRNA Translation: AAI20486.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37220.1

NCBI Reference Sequences

More...
RefSeqi
NP_034798.2, NM_010668.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023712; ENSMUSP00000023712; ENSMUSG00000064201

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16681

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16681

UCSC genome browser

More...
UCSCi
uc007xub.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74784 mRNA Translation: CAA52788.1
AK132476 mRNA Translation: BAE21186.1
AK161078 mRNA Translation: BAE36187.1
AK161098 mRNA Translation: BAE36194.1
BC120485 mRNA Translation: AAI20486.1
CCDSiCCDS37220.1
RefSeqiNP_034798.2, NM_010668.2

3D structure databases

SMRiQ3TTY5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201033, 12 interactors
IntActiQ3TTY5, 2 interactors
STRINGi10090.ENSMUSP00000023712

PTM databases

iPTMnetiQ3TTY5
PhosphoSitePlusiQ3TTY5

Proteomic databases

CPTACinon-CPTAC-3922
jPOSTiQ3TTY5
PaxDbiQ3TTY5
PRIDEiQ3TTY5
ProteomicsDBi269145

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1398, 281 antibodies

The DNASU plasmid repository

More...
DNASUi
16681

Genome annotation databases

EnsembliENSMUST00000023712; ENSMUSP00000023712; ENSMUSG00000064201
GeneIDi16681
KEGGimmu:16681
UCSCiuc007xub.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3849
MGIiMGI:96699, Krt2

Phylogenomic databases

eggNOGiENOG502QTM6, Eukaryota
GeneTreeiENSGT00940000162573
HOGENOMiCLU_012560_6_0_1
InParanoidiQ3TTY5
OMAiRDYERHV
OrthoDBi824246at2759
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-MMU-6805567, Keratinization
R-MMU-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
16681, 1 hit in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q3TTY5
RNActiQ3TTY5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000064201, Expressed in ear and 75 other tissues
GenevisibleiQ3TTY5, MM

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR032444, Keratin_2_head
IPR003054, Keratin_II
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PF16208, Keratin_2_head, 2 hits
PRINTSiPR01276, TYPE2KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK22E_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TTY5
Secondary accession number(s): Q0VBW1, Q61869
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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