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UniProtKB - Q3TTY0 (PLB1_MOUSE)

Entry version 100 (11 Dec 2019)
Sequence version 2 (18 Mar 2008)
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Protein

Phospholipase B1, membrane-associated

Gene

Plb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by diisopropyl fluorophosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei404NucleophileBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei478Substrate; via amide nitrogenBy similarity1
Binding sitei517SubstrateBy similarity1
Active sitei1006By similarity1
Active sitei1351By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.5 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1482788 Acyl chain remodelling of PC
R-MMU-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipase B1, membrane-associated
Short name:
Phospholipase B
Alternative name(s):
Phospholipase B/lipase
Short name:
PLB/LIP
Including the following 2 domains:
Phospholipase A2 (EC:3.1.1.4)
Lysophospholipase (EC:3.1.1.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plb1
Synonyms:Plb
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1922406 Plb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 1422ExtracellularSequence analysisAdd BLAST1399
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1423 – 1443HelicalSequence analysisAdd BLAST21
Topological domaini1444 – 1478CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032438524 – 1478Phospholipase B1, membrane-associatedAdd BLAST1455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi637N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi830N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1227N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage in the ileum.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3TTY0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3TTY0

PRoteomics IDEntifications database

More...PRIDEi		Q3TTY0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3TTY0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3TTY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000029134 Expressed in 66 organ(s), highest expression level in intestine

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3TTY0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000098928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3TTY0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 3511Add BLAST309
Repeati366 – 7112Add BLAST346
Repeati712 – 10583Add BLAST347
Repeati1068 – 14074Add BLAST340

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 14074 X 308-326 AA approximate repeatsAdd BLAST1365
Regioni1408 – 1450Necessary for membrane localizationBy similarityAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Repeat 2 contains the catalytic domain.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3670 Eukaryota
ENOG410ZM9P LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000115574

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3TTY0

KEGG Orthology (KO)

More...KOi		K14621

Identification of Orthologs from Complete Genome Data

More...OMAi		HYSPQNF

Database of Orthologous Groups

More...OrthoDBi		1232962at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3TTY0

TreeFam database of animal gene trees

More...TreeFami		TF314942

Family and domain databases

Conserved Domains Database

More...CDDi		cd01824 Phospholipase_B_like, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1110, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001087 GDSL
IPR008265 Lipase_GDSL_AS
IPR035547 Phospholipase_B
IPR038885 PLB1
IPR036514 SGNH_hydro_sf

The PANTHER Classification System

More...PANTHERi		PTHR21325 PTHR21325, 4 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00657 Lipase_GDSL, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01098 LIPASE_GDSL_SER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3TTY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELYPGVSPV GLLLLLLLGQ GPSQIHGSSG ENTLAWQSQQ VFWTLKNFPF 
        60         70         80         90        100
PCKPKKLELS VLSESVHSLR PSDIKLVAAI GNPEIPLAPG SGTINMEKPQ 
       110        120        130        140        150
SIKNQPQDVC MGIMTVLSDI IRHFSPSVLM PTCSPGKGTA VHTTAEDLWI 
       160        170        180        190        200
QAKELVRRLK DNPQLDFEKD WKLITVFFSN TSQCHLCPSA QQKSHLMRHM 
       210        220        230        240        250
EMLWGVLDYL HHEVPRAFVN LVDLSEVLAM DLQHQETGFS PAPEVCKCTE 
       260        270        280        290        300
TTTLSKAVMQ WSYQEAWEDL LASSKFNKHE TFAVVFQPFF DEIEPPLKRS 
       310        320        330        340        350
SPQDPTTLAL RIWNSMMEPV GQKDGLLNTA ERKTMKCPSE ESPYLFTYKN 
       360        370        380        390        400
SNYQARRLKP ITKLQMKEGS EFTCPDKNPS NSIPTTVHSL RPADIKIIGA 
       410        420        430        440        450
LGDSLTAGNG AGASPWNILD VLTEYRGLSW SVGGDETIKT VTTLPNILRE 
       460        470        480        490        500
FNPSLKGFSV GTGKESTSRA SFNQAVAGAK SDGLAGQARK LVDLMKADKT 
       510        520        530        540        550
INFQEDWKII TVFIGGNDLC ASCSNSTRFS PQNFIDNIKN ALDILHAEVP 
       560        570        580        590        600
RAFVNMAMVM EITPLRELFN EPTVSCPRNI LSRLCPCVLG LGDNSEELSS 
       610        620        630        640        650
LVQRNRDYQK KTEELINSGR YDTRDNFTVV VQPLFENVSM PRTPEGVPDK 
       660        670        680        690        700
SFFAPDCFHF NAKTHARSAI ALWKNMLEPV GHKTRHNNFE IKAPIVCPNQ 
       710        720        730        740        750
ASPFLSTTKN SNLGNGTWMV CEERAPSASP PTSVHTLRPA DIQVVAALGD 
       760        770        780        790        800
SLTAGNGISS QEGNLTDVST QYRGLSYSAG GDKTLENVTT LPNILRKFNG 
       810        820        830        840        850
NLTGYSVGTG DSSSANAFLN QAVPGAKAEN LTSQVRTLVQ KMKSDNRVNF 
       860        870        880        890        900
NRDWKVITVM IGASDLCDFC TDSNHYSAAN FFDHLQNALD ILHKEVPRAL 
       910        920        930        940        950
VNLVDFINPS IIREVFLKNP DKCPVNQSSV LCNCVLTPRK DSYELARLEA 
       960        970        980        990       1000
FTKSYQSSML QLVESGRYDT REDFSVVLQP FLLNTKLPVL ENGKPDTSFF 
      1010       1020       1030       1040       1050
APDCIHLNQK FHTQLARALW ANMLEPLGKK TDTLDPKGHI SLACPTKDQP 
      1060       1070       1080       1090       1100
FLRTFRNSNY KYPTKPAIEN WGSDFLCTEK SPSSQVPTSV HELRPADIKV 
      1110       1120       1130       1140       1150
VAAMGDFLTT ATGARPSGYK RLATPWRGLS WSIGGDGKLE THTTLPNILK 
      1160       1170       1180       1190       1200
KFNPSITGFS TGTLDNKAGL NVAEEGARAQ DMPAQAKTLV KKMKSTPTIN 
      1210       1220       1230       1240       1250
LQEDWKLITL LIGNNDLCLY CENPEDNSTK EYVKYIQQAL DILYEELPRV 
      1260       1270       1280       1290       1300
FINVVEVMEL AGLHHVQGGK CAMPLAVQKN CSCLRHSQNL TAMQELKKLN 
      1310       1320       1330       1340       1350
WNLQSGISEL SYWHRYMERE DFAVTVQPFF RNTFIPLNER EGLDLTFFSE 
      1360       1370       1380       1390       1400
DCFYFSDRGH AEMAIALWNN MLEPVGWKTS SNNFIYNRTK LKCPSPERPF 
      1410       1420       1430       1440       1450
LYTLRNSQLL PDKAEEPSNA LYWAVPVAAI GGLAVGILGV MLWRTVKPVQ 
      1460       1470 
QEEEEEDTLP NTSVTQDAVS EKRLKAGN
Length:1,478
Mass (Da):164,541
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5361AED29BA49E6
GO
Isoform 2 (identifier: Q3TTY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-778: S → R
     779-1478: Missing.

Show »
Length:778
Mass (Da):86,140
Checksum:i2E08238E090D67AA
GO
Isoform 3 (identifier: Q3TTY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-929: S → R
     930-1478: Missing.

Show »
Length:929
Mass (Da):102,708
Checksum:i8AA3E12EB262376A
GO
Isoform 4 (identifier: Q3TTY0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-394: VHSLRPAD → GTWLSCSV
     395-1478: Missing.

Show »
Length:394
Mass (Da):44,290
Checksum:iE6DB3EC17E8F0888
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI19078 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032233387 – 394VHSLRPAD → GTWLSCSV in isoform 4. 1 Publication8
Alternative sequenceiVSP_032234395 – 1478Missing in isoform 4. 1 PublicationAdd BLAST1084
Alternative sequenceiVSP_032235778S → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_032236779 – 1478Missing in isoform 2. 1 PublicationAdd BLAST700
Alternative sequenceiVSP_032237929S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_032238930 – 1478Missing in isoform 3. 1 PublicationAdd BLAST549

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK015993 mRNA Translation: BAB30072.1
AK161095 mRNA Translation: BAE36193.1
AC102372 Genomic DNA No translation available.
AC111030 Genomic DNA No translation available.
BC119077 mRNA Translation: AAI19078.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39060.1 [Q3TTY0-1]

NCBI Reference Sequences

More...RefSeqi		NP_001074876.1, NM_001081407.1 [Q3TTY0-1]
NP_084348.1, NM_030072.1
XP_006504110.1, XM_006504047.2 [Q3TTY0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000101376; ENSMUSP00000098927; ENSMUSG00000029134 [Q3TTY0-1]
ENSMUST00000202201; ENSMUSP00000144401; ENSMUSG00000029134 [Q3TTY0-2]
ENSMUST00000202220; ENSMUSP00000144040; ENSMUSG00000029134 [Q3TTY0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		665270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:665270

UCSC genome browser

More...UCSCi		uc008wzk.1 mouse [Q3TTY0-4]
uc008wzl.1 mouse [Q3TTY0-3]
uc008wzm.1 mouse [Q3TTY0-2]
uc008wzn.1 mouse [Q3TTY0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015993 mRNA Translation: BAB30072.1
AK161095 mRNA Translation: BAE36193.1
AC102372 Genomic DNA No translation available.
AC111030 Genomic DNA No translation available.
BC119077 mRNA Translation: AAI19078.1 Different initiation.
CCDSiCCDS39060.1 [Q3TTY0-1]
RefSeqiNP_001074876.1, NM_001081407.1 [Q3TTY0-1]
NP_084348.1, NM_030072.1
XP_006504110.1, XM_006504047.2 [Q3TTY0-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098928

PTM databases

iPTMnetiQ3TTY0
PhosphoSitePlusiQ3TTY0

Proteomic databases

MaxQBiQ3TTY0
PaxDbiQ3TTY0
PRIDEiQ3TTY0

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		665270

Genome annotation databases

EnsembliENSMUST00000101376; ENSMUSP00000098927; ENSMUSG00000029134 [Q3TTY0-1]
ENSMUST00000202201; ENSMUSP00000144401; ENSMUSG00000029134 [Q3TTY0-2]
ENSMUST00000202220; ENSMUSP00000144040; ENSMUSG00000029134 [Q3TTY0-1]
GeneIDi665270
KEGGimmu:665270
UCSCiuc008wzk.1 mouse [Q3TTY0-4]
uc008wzl.1 mouse [Q3TTY0-3]
uc008wzm.1 mouse [Q3TTY0-2]
uc008wzn.1 mouse [Q3TTY0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		151056
MGIiMGI:1922406 Plb1

Phylogenomic databases

eggNOGiKOG3670 Eukaryota
ENOG410ZM9P LUCA
GeneTreeiENSGT00530000063883
HOGENOMiHOG000115574
InParanoidiQ3TTY0
KOiK14621
OMAiHYSPQNF
OrthoDBi1232962at2759
PhylomeDBiQ3TTY0
TreeFamiTF314942

Enzyme and pathway databases

BRENDAi3.1.1.5 3474
ReactomeiR-MMU-1482788 Acyl chain remodelling of PC
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pln mouse

Protein Ontology

More...PROi		PR:Q3TTY0
RNActiQ3TTY0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000029134 Expressed in 66 organ(s), highest expression level in intestine
GenevisibleiQ3TTY0 MM

Family and domain databases

CDDicd01824 Phospholipase_B_like, 4 hits
Gene3Di3.40.50.1110, 2 hits
InterProiView protein in InterPro
IPR001087 GDSL
IPR008265 Lipase_GDSL_AS
IPR035547 Phospholipase_B
IPR038885 PLB1
IPR036514 SGNH_hydro_sf
PANTHERiPTHR21325 PTHR21325, 4 hits
PfamiView protein in Pfam
PF00657 Lipase_GDSL, 3 hits
PROSITEiView protein in PROSITE
PS01098 LIPASE_GDSL_SER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLB1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TTY0
Secondary accession number(s): Q0VEX7, Q9D4Y6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 11, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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