Yy2

Functionⁱ

Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.1 Publication

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	260 – 284	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	289 – 311	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	317 – 341	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	347 – 371	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16260628
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II Source: MGI
regulation of transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-MMU-381033 ATF6 (ATF6-alpha) activates chaperones R-MMU-8874211 CREB3 factors activate genes

Reactomeⁱ

R-MMU-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-MMU-381033 ATF6 (ATF6-alpha) activates chaperones
R-MMU-8874211 CREB3 factors activate genes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor YY2 Alternative name(s): Yin and yang 2 Short name: YY-2
Gene namesⁱ	Name:Yy2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:3837947 Yy2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000323761	1 – 378	Transcription factor YY2Add BLAST		378

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3TTC2
PaxDbⁱ	Q3TTC2
PeptideAtlas More...PeptideAtlasⁱ	Q3TTC2
PRIDEⁱ	Q3TTC2

PTM databases

iPTMnetⁱ	Q3TTC2
PhosphoSitePlusⁱ	Q3TTC2

Expressionⁱ

Tissue specificityⁱ

Weakly expressed by neuronal and glial cells in the cerebral cortex. Expressed by Purkinje cells and in the granular layers of the cerebellum. Expressed in all layers of spermatocytes in testis but not detected in sperm cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000046873 Expressed in 238 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	Q3TTC2 baseline and differential
Genevisibleⁱ	Q3TTC2 MM

Interactionⁱ

GO - Molecular functionⁱ

RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000070112

STRINGⁱ

10090.ENSMUSP00000070112

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3TTC2
SMRⁱ	Q3TTC2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	39 – 113	Mediates transcriptional activationBy similarityAdd BLAST		75
Regionⁱ	243 – 378	Mediates transcriptional repressionBy similarityAdd BLAST		136

Sequence similaritiesⁱ

Belongs to the YY transcription factor family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	260 – 284	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	289 – 311	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	317 – 341	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	347 – 371	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048066 ENSGT00910000144040
HOGENOMⁱ	HOG000008232
HOVERGENⁱ	HBG006823
InParanoidⁱ	Q3TTC2
KEGG Orthology (KO) More...KOⁱ	K09201
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03FM
PhylomeDBⁱ	Q3TTC2
TreeFamⁱ	TF106493

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3TTC2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASETEKLLC LNTESAEIPA DFVELLPPDN IGDIEAVSLE TSVGQTIEVY 
        60         70         80         90        100
GDVGVDWAHG SQYHSPVIAL QPLVGSSLSS RDHDKEMFVV QTREEEVVGY 
       110        120        130        140        150
QDSDNLLFSP EFGSQMVLPV NEDDYLQPTT ASFTGFLAAE NGQGELSPYE 
       160        170        180        190        200
GNLCGLTTFI EAGAEESVNA DLGDKQWEQK QIDGLDGEFP FTMWDDVNEK 
       210        220        230        240        250
EDPIAEEQAG ESPPDYSEYM TGKKFPPEGI PGIDLSDPKQ LAEFTSMRPK 
       260        270        280        290        300
KPKGDFPRPI ACSHKGCEKM FKDNSAMRKH LHIHGPRVHV CAECGKAFVE 
       310        320        330        340        350
SSKLKRHQLV HTGEKPYQCT FEGCGRRFSL DFNLRTHVRI HTGDKPFVCP 
       360        370 
FDACNKKFAQ STNLKSHILT HVKNKNDQ

Length:378

Mass (Da):42,031

Last modified:October 11, 2005 - v1

Checksum:ⁱ8B2E3C9BDFD0FC36

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	327	R → H in BAC29297 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF688658 Genomic DNA Translation: ABS18955.1 AK036071 mRNA Translation: BAC29297.1 AK161451 mRNA Translation: BAE36403.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53233.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001092193.1, NM_001098723.1
UniGeneⁱ	Mm.37577 Mm.491276

Genome annotation databases

Ensemblⁱ	ENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736 ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873
GeneIDⁱ	100073351
KEGGⁱ	mmu:100073351
UCSC genome browser More...UCSCⁱ	uc012hra.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3TTC2	YY2 transcription factor		AILME		390	UniRef50_Q3TTC2
Putative transcriptional repressor protein YY1-like		SCOMX		443
Transcriptional repressor protein YY1		FUNHE		401
transcriptional repressor protein YY1-like isoform X1		Austrofundulus limnaeus		378
Uncharacterized protein		XIPMA		370
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF688658 Genomic DNA Translation: ABS18955.1 AK036071 mRNA Translation: BAC29297.1 AK161451 mRNA Translation: BAE36403.1
CCDSⁱ	CCDS53233.1
RefSeqⁱ	NP_001092193.1, NM_001098723.1
UniGeneⁱ	Mm.37577 Mm.491276

3D structure databases

ProteinModelPortalⁱ	Q3TTC2
SMRⁱ	Q3TTC2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000070112

STRINGⁱ

10090.ENSMUSP00000070112

PTM databases

iPTMnetⁱ	Q3TTC2
PhosphoSitePlusⁱ	Q3TTC2

Proteomic databases

MaxQBⁱ	Q3TTC2
PaxDbⁱ	Q3TTC2
PeptideAtlasⁱ	Q3TTC2
PRIDEⁱ	Q3TTC2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736 ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873
GeneIDⁱ	100073351
KEGGⁱ	mmu:100073351
UCSCⁱ	uc012hra.2 mouse

Organism-specific databases

CTDⁱ	404281
MGIⁱ	MGI:3837947 Yy2

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00510000048066 ENSGT00910000144040
HOGENOMⁱ	HOG000008232
HOVERGENⁱ	HBG006823
InParanoidⁱ	Q3TTC2
KOⁱ	K09201
OrthoDBⁱ	EOG091G03FM
PhylomeDBⁱ	Q3TTC2
TreeFamⁱ	TF106493

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-MMU-381033 ATF6 (ATF6-alpha) activates chaperones R-MMU-8874211 CREB3 factors activate genes

Reactomeⁱ

R-MMU-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-MMU-381033 ATF6 (ATF6-alpha) activates chaperones
R-MMU-8874211 CREB3 factors activate genes

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3TTC2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000046873 Expressed in 238 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	Q3TTC2 baseline and differential
Genevisibleⁱ	Q3TTC2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TYY2_MOUSE
Accessionⁱ	Q3TTC2Primary (citable) accession number: Q3TTC2 Secondary accession number(s): Q8CBG3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3TTC2 (TYY2_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription factor YY2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ