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UniProtKB - Q3TTC2 (TYY2_MOUSE)
Protein
Transcription factor YY2
Gene
Yy2
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.
1 PublicationMiscellaneous
The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene Mbtps2.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 260 – 284 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 289 – 311 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 341 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 347 – 371 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor YY2Alternative name(s): Yin and yang 2 Short name: YY-2 |
Gene namesi | Name:Yy2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3837947, Yy2 |
VEuPathDBi | HostDB:ENSMUSG00000046873 HostDB:ENSMUSG00000091736 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: MGI
- PcG protein complex Source: GO_Central
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000323761 | 1 – 378 | Transcription factor YY2Add BLAST | 378 |
Proteomic databases
jPOSTi | Q3TTC2 |
MaxQBi | Q3TTC2 |
PaxDbi | Q3TTC2 |
PeptideAtlasi | Q3TTC2 |
PRIDEi | Q3TTC2 |
PTM databases
iPTMneti | Q3TTC2 |
PhosphoSitePlusi | Q3TTC2 |
Expressioni
Tissue specificityi
Weakly expressed by neuronal and glial cells in the cerebral cortex. Expressed by Purkinje cells and in the granular layers of the cerebellum. Expressed in all layers of spermatocytes in testis but not detected in sperm cells.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000046873, Expressed in embryo and 264 other tissues |
ExpressionAtlasi | Q3TTC2, baseline and differential |
Genevisiblei | Q3TTC2, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 791913, 4 interactors |
STRINGi | 10090.ENSMUSP00000070112 |
Miscellaneous databases
RNActi | Q3TTC2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 39 – 113 | Mediates transcriptional activationBy similarityAdd BLAST | 75 | |
Regioni | 243 – 378 | Mediates transcriptional repressionBy similarityAdd BLAST | 136 |
Sequence similaritiesi
Belongs to the YY transcription factor family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 260 – 284 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 289 – 311 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 341 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 347 – 371 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00510000048066 ENSGT00940000154763 |
HOGENOMi | CLU_002678_42_2_1 |
InParanoidi | Q3TTC2 |
OMAi | PACERTF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3TTC2 |
TreeFami | TF106493 |
Family and domain databases
InterProi | View protein in InterPro IPR017114, YY1-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
PIRSFi | PIRSF037113, TF_Yin_yang, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q3TTC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASETEKLLC LNTESAEIPA DFVELLPPDN IGDIEAVSLE TSVGQTIEVY
60 70 80 90 100
GDVGVDWAHG SQYHSPVIAL QPLVGSSLSS RDHDKEMFVV QTREEEVVGY
110 120 130 140 150
QDSDNLLFSP EFGSQMVLPV NEDDYLQPTT ASFTGFLAAE NGQGELSPYE
160 170 180 190 200
GNLCGLTTFI EAGAEESVNA DLGDKQWEQK QIDGLDGEFP FTMWDDVNEK
210 220 230 240 250
EDPIAEEQAG ESPPDYSEYM TGKKFPPEGI PGIDLSDPKQ LAEFTSMRPK
260 270 280 290 300
KPKGDFPRPI ACSHKGCEKM FKDNSAMRKH LHIHGPRVHV CAECGKAFVE
310 320 330 340 350
SSKLKRHQLV HTGEKPYQCT FEGCGRRFSL DFNLRTHVRI HTGDKPFVCP
360 370
FDACNKKFAQ STNLKSHILT HVKNKNDQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MQE2 | A0A0A0MQE2_MOUSE | Membrane-bound transcription factor... | Mbtps2 | 220 | Annotation score: | ||
A2AC84 | A2AC84_MOUSE | Membrane-bound transcription factor... | Mbtps2 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 327 | R → H in BAC29297 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF688658 Genomic DNA Translation: ABS18955.1 AK036071 mRNA Translation: BAC29297.1 AK161451 mRNA Translation: BAE36403.1 |
CCDSi | CCDS53233.1 |
RefSeqi | NP_001092193.1, NM_001098723.1 |
Genome annotation databases
Ensembli | ENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736 ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873 |
GeneIDi | 100073351 |
KEGGi | mmu:100073351 |
UCSCi | uc012hra.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF688658 Genomic DNA Translation: ABS18955.1 AK036071 mRNA Translation: BAC29297.1 AK161451 mRNA Translation: BAE36403.1 |
CCDSi | CCDS53233.1 |
RefSeqi | NP_001092193.1, NM_001098723.1 |
3D structure databases
AlphaFoldDBi | Q3TTC2 |
SMRi | Q3TTC2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 791913, 4 interactors |
STRINGi | 10090.ENSMUSP00000070112 |
PTM databases
iPTMneti | Q3TTC2 |
PhosphoSitePlusi | Q3TTC2 |
Proteomic databases
jPOSTi | Q3TTC2 |
MaxQBi | Q3TTC2 |
PaxDbi | Q3TTC2 |
PeptideAtlasi | Q3TTC2 |
PRIDEi | Q3TTC2 |
Protocols and materials databases
Antibodypediai | 483, 149 antibodies from 28 providers |
Genome annotation databases
Ensembli | ENSMUST00000065806; ENSMUSP00000070112; ENSMUSG00000091736 ENSMUST00000179062; ENSMUSP00000137233; ENSMUSG00000046873 |
GeneIDi | 100073351 |
KEGGi | mmu:100073351 |
UCSCi | uc012hra.2, mouse |
Organism-specific databases
CTDi | 404281 |
MGIi | MGI:3837947, Yy2 |
VEuPathDBi | HostDB:ENSMUSG00000046873 HostDB:ENSMUSG00000091736 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00510000048066 ENSGT00940000154763 |
HOGENOMi | CLU_002678_42_2_1 |
InParanoidi | Q3TTC2 |
OMAi | PACERTF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q3TTC2 |
TreeFami | TF106493 |
Miscellaneous databases
BioGRID-ORCSi | 100073351, 3 hits in 40 CRISPR screens |
PROi | PR:Q3TTC2 |
RNActi | Q3TTC2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046873, Expressed in embryo and 264 other tissues |
ExpressionAtlasi | Q3TTC2, baseline and differential |
Genevisiblei | Q3TTC2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR017114, YY1-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
PIRSFi | PIRSF037113, TF_Yin_yang, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TYY2_MOUSE | |
Accessioni | Q3TTC2Primary (citable) accession number: Q3TTC2 Secondary accession number(s): Q8CBG3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 11, 2005 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families