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Protein

Microtubule-associated protein 9

Gene

Map9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 9
Alternative name(s):
Aster-associated protein
Gene namesi
Name:Map9
Synonyms:Asap, Mtap9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442208 Map9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002477542 – 646Microtubule-associated protein 9Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei12PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ3TRR0
PaxDbiQ3TRR0
PeptideAtlasiQ3TRR0
PRIDEiQ3TRR0

PTM databases

iPTMnetiQ3TRR0
PhosphoSitePlusiQ3TRR0

Expressioni

Gene expression databases

BgeeiENSMUSG00000033900
CleanExiMM_MTAP9
ExpressionAtlasiQ3TRR0 baseline and differential
GenevisibleiQ3TRR0 MM

Interactioni

Subunit structurei

Binds to purified microtubules via its C-terminus.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229458, 3 interactors
IntActiQ3TRR0, 4 interactors
MINTiQ3TRR0
STRINGi10090.ENSMUSP00000088535

Structurei

3D structure databases

ProteinModelPortaliQ3TRR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili442 – 596Sequence analysisAdd BLAST155

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGGW Eukaryota
ENOG4111X21 LUCA
GeneTreeiENSGT00730000111184
HOVERGENiHBG081953
InParanoidiQ3TRR0
KOiK10434
OMAiEDRNMKN
OrthoDBiEOG091G07GL
PhylomeDBiQ3TRR0
TreeFamiTF328794

Family and domain databases

InterProiView protein in InterPro
IPR026106 MAP9
PANTHERiPTHR14739 PTHR14739, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3TRR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDEIFSTTL AYTKSPKATK RTSFQDELIR AITARSARQR SSEYSDDFDS
60 70 80 90 100
DEIVSLGEFS DTSTDESLVR KKMNDFHISD DEEKNSPRLS FLKTKKVNRA
110 120 130 140 150
ISNDALDSST PGSEGSSPDA QEDVTGDSLP KSQNDDREVG REIITVKPTP
160 170 180 190 200
RMHPVKRSTS SGETSSGLDA DGHFKPSPQP RSMLKKSSHT EEGVRPGVDK
210 220 230 240 250
EHSISEASAP TPSLPRQNGT ELQTEEKIYS ENLDLEDSLL QSLTSSSFKE
260 270 280 290 300
SPGGCTSPGS QEKVPIKDHD GEPTEIWDSL LSNENEGSSV LVNCVTPELE
310 320 330 340 350
QPKDGQVAAD DLEEEREKGG FTEDDLTTDP LLSTSPSVIT PTEPAEPAKK
360 370 380 390 400
ANEDRNTKNK KTTNNRVSSA SGRLMTSEFL KRSGPTKRSP SAATSSHYLG
410 420 430 440 450
SLKVLDQKQP RKQSLEPDKA DHIRAAVYQE WLEKKNVYLH EMHRIKRIES
460 470 480 490 500
ENLRIQNEQK KAAKREEALA SFEAWKAMKE KEAKRIAAKK RLEEKNKKKT
510 520 530 540 550
EEENAMRKGE ALQAFEKWKE KKLEYLKEKT RREKEYERAK KQKEEEAVAE
560 570 580 590 600
KKKDSLTAFE KWSERKEALL KQKEKEKINE RRKEELKRAE KKDKDKQAIS
610 620 630 640
EYEKWLEKKE RQERIERKQK KRHSFLESET HPPWSPPSRT APSKVF
Length:646
Mass (Da):73,511
Last modified:July 25, 2006 - v2
Checksum:iF5309EDE68557839
GO
Isoform 2 (identifier: Q3TRR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-458: Missing.

Note: No experimental confirmation available.
Show »
Length:616
Mass (Da):69,664
Checksum:iCD703E5F9566DEC5
GO

Sequence cautioni

The sequence AAH61216 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH87935 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AK147287 differs from that shown. Reason: Frameshift at position 84.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185K → P in BAE36967 (PubMed:16141072).Curated1
Sequence conflicti205S → H in BAE36967 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020039429 – 458Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030527 mRNA Translation: BAC27004.2
AK038737 mRNA Translation: BAC30117.1
AK135702 mRNA Translation: BAE22616.1
AK135823 mRNA Translation: BAE22678.1
AK138540 mRNA Translation: BAE23696.1
AK147287 mRNA No translation available.
AK162555 mRNA Translation: BAE36967.1
BC061216 mRNA Translation: AAH61216.1 Sequence problems.
BC087935 mRNA Translation: AAH87935.1 Sequence problems.
CCDSiCCDS38461.1 [Q3TRR0-1]
RefSeqiNP_001074699.1, NM_001081230.1 [Q3TRR0-1]
XP_006501341.1, XM_006501278.3
UniGeneiMm.271269

Genome annotation databases

EnsembliENSMUST00000091014; ENSMUSP00000088535; ENSMUSG00000033900 [Q3TRR0-1]
ENSMUST00000195640; ENSMUSP00000142206; ENSMUSG00000033900 [Q3TRR0-1]
GeneIDi213582
KEGGimmu:213582
UCSCiuc008pow.1 mouse [Q3TRR0-1]
uc012cqt.1 mouse [Q3TRR0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMAP9_MOUSE
AccessioniPrimary (citable) accession number: Q3TRR0
Secondary accession number(s): Q3UUD1
, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 18, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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