UniProtKB - Q3TR40 (Q3TR40_MOUSE)
Protein
Submitted name:
Uncharacterized protein
Gene
Thbs1
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: UniProtKB-UniRule
- extracellular matrix binding Source: InterPro
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- inflammatory response Source: InterPro
- negative regulation of angiogenesis Source: InterPro
Keywordsi
Molecular function | Heparin-bindingARBA annotation |
Biological process | Cell adhesionARBA annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:Thbs1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98737, Thbs1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5004229565 | 19 – 1170 | Sequence analysisAdd BLAST | 1152 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | Q3TR40 |
PRIDEi | Q3TR40 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 316 – 373 | VWFCInterPro annotationAdd BLAST | 58 | |
Domaini | 547 – 587 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 646 – 690 | EGF-likeInterPro annotationAdd BLAST | 45 | |
Repeati | 691 – 726 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 727 – 762 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 763 – 785 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 23 | |
Repeati | 786 – 821 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 822 – 844 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 23 | |
Repeati | 845 – 882 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 38 | |
Repeati | 883 – 918 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 919 – 954 | TSP type-3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 958 – 1170 | TSP C-terminalInterPro annotationAdd BLAST | 213 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 840 – 934 | DisorderedSequence analysisAdd BLAST | 95 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 291 – 311 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 883 – 897 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 903 – 934 | PolyampholyteSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the thrombospondin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotationPhylogenomic databases
OMAi | CIHNGIL |
OrthoDBi | 120983at2759 |
Family and domain databases
Gene3Di | 2.20.100.10, 3 hits 4.10.1080.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR001791, Laminin_G IPR028499, Thrombospondin-1 IPR003367, Thrombospondin_3-like_rpt IPR017897, Thrombospondin_3_rpt IPR008859, Thrombospondin_C IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR028974, TSP_type-3_rpt IPR001007, VWF_dom |
PANTHERi | PTHR10199:SF78, PTHR10199:SF78, 1 hit |
Pfami | View protein in Pfam PF00090, TSP_1, 3 hits PF02412, TSP_3, 7 hits PF05735, TSP_C, 1 hit PF00093, VWC, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00179, EGF_CA, 2 hits SM00209, TSP1, 3 hits SM00210, TSPN, 1 hit SM00214, VWC, 1 hit |
SUPFAMi | SSF103647, SSF103647, 3 hits SSF49899, SSF49899, 2 hits SSF82895, SSF82895, 3 hits |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS50092, TSP1, 3 hits PS51234, TSP3, 8 hits PS51236, TSP_CTER, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3TR40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELLRGLGVL FLLHMCGSNR IPESGGDNGV FDIFELIGGA RRGPGRRLVK
60 70 80 90 100
GQDLSSPAFR IENANLIPAV PDDKFQDLLD AVWADKGFIF LASLRQMKKT
110 120 130 140 150
RGTLLAVERK DNTGQIFSVV SNGKAGTLDL SLSLPGKQQV VSVEEALLAT
160 170 180 190 200
GQWKSITLFV QEDRAQLYID CDKMESAELD VPIQSIFTRD LASVARLRVA
210 220 230 240 250
KGDVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSTNVLL TLDNNVVNGS
260 270 280 290 300
SPAIRTNYIG HKTKDLQAIC GLSCDELSSM VLELKGLRTI VTTLQDSIRK
310 320 330 340 350
VTEENRELVS ELKRPPLCFH NGVQYKNNEE WTVDSCTECH CQNSVTICKK
360 370 380 390 400
VSCPIMPCSN ATVPDGECCP RCWPSDSADD GWSPWSEWTS CSATCGNGIQ
410 420 430 440 450
QRGRSCDSLN NRCEGSSVQT RTCHIQECDK RFKQDGGWSH WSPWSSCSVT
460 470 480 490 500
CGDGVITRIR LCNSPSPQMN GKPCEGEARE TKACKKDACP INGGWGPWSP
510 520 530 540 550
WDICSVTCGG GVQRRSRLCN NPTPQFGGKD CVGDVTENQV CNKQDCPIDG
560 570 580 590 600
CLSNPCFAGA KCTSYPDGSW KCGACPPGYS GNGIQCKDVD ECKEVPDACF
610 620 630 640 650
NHNGEHRCKN TDPGYNCLPC PPRFTGSQPF GRGVEHAMAN KQVCKPRNPC
660 670 680 690 700
TDGTHDCNKN AKCNYLGHYS DPMYRCECKP GYAGNGIICG EDTDLDGWPN
710 720 730 740 750
ENLVCVANAT YHCKKDNCPN LPNSGQEDYD KDGIGDACDD DDDNDKIPDD
760 770 780 790 800
RDNCPFHYNP AQYDYDRDDV GDRCDNCPYN HNPDQADTDK NGEGDACAVD
810 820 830 840 850
IDGDGILNER DNCQYVYNVD QRDTDMDGVG DQCDNCPLEH NPDQLDSDSD
860 870 880 890 900
LIGDTCDNNQ DIDEDGHQNN LDNCPYVPNA NQADHDKDGK GDACDHDDDN
910 920 930 940 950
DGIPDDRDNC RLVPNPDQKD SDGDGRGDAC KDDFDHDNVP DIDDICPENF
960 970 980 990 1000
DISETDFRQF QMIPLDPKGT SQNDPNWVVR HQGKELVQTV NCDPGLAVGY
1010 1020 1030 1040 1050
DEFNAVDFSG TFFINTERDD DYAGFVFGYQ SSSRFYVVMW KQVTQSYWDT
1060 1070 1080 1090 1100
NPTRAQGYSG LSVKVVNSTT GPGEHLRNAL WHTGNTPGQV RTLWHDPRHI
1110 1120 1130 1140 1150
GWKDFTAYRW RLSHRPKTGY IRVVMYEGKK IMADSGPIYD KTYAGGRLGL
1160 1170
FVFSQEMVFF SDMKYECRDS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK163092 mRNA Translation: BAE37190.1 |
RefSeqi | NP_001300843.1, NM_001313914.1 NP_035710.2, NM_011580.4 |
Genome annotation databases
GeneIDi | 21825 |
KEGGi | mmu:21825 |
UCSCi | uc008lrr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK163092 mRNA Translation: BAE37190.1 |
RefSeqi | NP_001300843.1, NM_001313914.1 NP_035710.2, NM_011580.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q3TR40 |
PRIDEi | Q3TR40 |
Protocols and materials databases
DNASUi | 21825 |
Genome annotation databases
GeneIDi | 21825 |
KEGGi | mmu:21825 |
UCSCi | uc008lrr.1, mouse |
Organism-specific databases
CTDi | 7057 |
MGIi | MGI:98737, Thbs1 |
Phylogenomic databases
OMAi | CIHNGIL |
OrthoDBi | 120983at2759 |
Miscellaneous databases
BioGRID-ORCSi | 21825, 1 hit in 54 CRISPR screens |
ChiTaRSi | Thbs1, mouse |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.20.100.10, 3 hits 4.10.1080.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR001791, Laminin_G IPR028499, Thrombospondin-1 IPR003367, Thrombospondin_3-like_rpt IPR017897, Thrombospondin_3_rpt IPR008859, Thrombospondin_C IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR028974, TSP_type-3_rpt IPR001007, VWF_dom |
PANTHERi | PTHR10199:SF78, PTHR10199:SF78, 1 hit |
Pfami | View protein in Pfam PF00090, TSP_1, 3 hits PF02412, TSP_3, 7 hits PF05735, TSP_C, 1 hit PF00093, VWC, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00179, EGF_CA, 2 hits SM00209, TSP1, 3 hits SM00210, TSPN, 1 hit SM00214, VWC, 1 hit |
SUPFAMi | SSF103647, SSF103647, 3 hits SSF49899, SSF49899, 2 hits SSF82895, SSF82895, 3 hits |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS50092, TSP1, 3 hits PS51234, TSP3, 8 hits PS51236, TSP_CTER, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TR40_MOUSE | |
Accessioni | Q3TR40Primary (citable) accession number: Q3TR40 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |