UniProtKB - Q3TQS0 (Q3TQS0_MOUSE)
Protein
Calreticulin
Gene
Calr4
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 50 | Calcium; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 95 | CarbohydrateUniRule annotation | 1 | |
Binding sitei | 97 | CarbohydrateUniRule annotation | 1 | |
Binding sitei | 114 | CarbohydrateUniRule annotation | 1 | |
Binding sitei | 121 | CarbohydrateUniRule annotation | 1 | |
Binding sitei | 303 | CarbohydrateUniRule annotation | 1 | |
Metal bindingi | 314 | CalciumUniRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- unfolded protein binding Source: InterPro
GO - Biological processi
- endoplasmic reticulum unfolded protein response Source: GO_Central
- protein folding Source: GO_Central
Keywordsi
Molecular function | ChaperoneUniRule annotationARBA annotation |
Ligand | CalciumUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: CalreticulinUniRule annotation |
Gene namesi | Name:Calr4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2140435, Calr4 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen UniRule annotationARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
- endoplasmic reticulum membrane Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | UniRule annotationAdd BLAST | 18 | |
ChainiPRO_5015020010 | 19 – 420 | CalreticulinUniRule annotationAdd BLAST | 402 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 91 ↔ 123 | UniRule annotation |
Proteomic databases
PRIDEi | Q3TQS0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028558, Expressed in primary oocyte and 54 other tissues |
ExpressionAtlasi | Q3TQS0, baseline and differential |
Interactioni
GO - Molecular functioni
- unfolded protein binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030285 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 199 – 240 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 352 – 420 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 352 – 374 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 375 – 394 | AcidicSequence analysisAdd BLAST | 20 | |
Compositional biasi | 395 – 420 | PolyampholyteSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0674, Eukaryota |
GeneTreei | ENSGT00950000182915 |
HOGENOMi | CLU_018224_0_2_1 |
OMAi | AQKPRKW |
OrthoDBi | 822188at2759 |
TreeFami | TF338438 |
Family and domain databases
Gene3Di | 2.10.250.10, 2 hits |
InterProi | View protein in InterPro IPR001580, Calret/calnex IPR018124, Calret/calnex_CS IPR009169, Calreticulin IPR009033, Calreticulin/calnexin_P_dom_sf IPR013320, ConA-like_dom_sf |
PANTHERi | PTHR11073, PTHR11073, 1 hit |
Pfami | View protein in Pfam PF00262, Calreticulin, 2 hits |
PIRSFi | PIRSF002356, Calreticulin, 1 hit |
PRINTSi | PR00626, CALRETICULIN |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF63887, SSF63887, 1 hit |
PROSITEi | View protein in PROSITE PS00803, CALRETICULIN_1, 1 hit PS00804, CALRETICULIN_2, 1 hit PS00805, CALRETICULIN_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3TQS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCWFFFFSLS LSPFSTDGWT KRWVQSKHQS DYGQFQLASG KFYQDKERDK
60 70 80 90 100
GLQTTEDAKF YALSTRFKPF SNENETLVVQ FSVKHEQGID CGGGYVKLFP
110 120 130 140 150
AALNQEDMHS ESQYYIMFGP DICGFGNNRL QVILSHKGKY HENNKTLKCR
160 170 180 190 200
INKDTHLYTL ILRPNATYEV KIDNQKVTSG GLEDDWDFLP PKKIKDPYAR
210 220 230 240 250
KPRKWDERQQ IEDPDDKKPE DWEDSEFIPD PDAKKPDDWN EAMDGVWEGP
260 270 280 290 300
LIPNVKYMGE WKPRIIDNPN YQGEWIHPEI DNPKYRPDPT IGHYHNISVL
310 320 330 340 350
GLDLWQVKSG SIFDNFLLTN DEEFAEEVGN MTWGLRKDVE QQWRELYEEM
360 370 380 390 400
EKQKEAEETK KKREKERARQ EDVWGLDEED EEDAEEDDEE EAEERLKQEG
410 420
SAARASLDQK EAHLDQKDEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2A8Z3 | A2A8Z3_MOUSE | Calreticulin 4 | Calr4 | 313 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL627103 Genomic DNA No translation available. AK163350 mRNA Translation: BAE37312.1 |
RefSeqi | NP_001028398.1, NM_001033226.4 |
Genome annotation databases
Ensembli | ENSMUST00000030285; ENSMUSP00000030285; ENSMUSG00000028558 |
GeneIDi | 108802 |
KEGGi | mmu:108802 |
UCSCi | uc008uce.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL627103 Genomic DNA No translation available. AK163350 mRNA Translation: BAE37312.1 |
RefSeqi | NP_001028398.1, NM_001033226.4 |
3D structure databases
SMRi | Q3TQS0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030285 |
Proteomic databases
PRIDEi | Q3TQS0 |
Genome annotation databases
Ensembli | ENSMUST00000030285; ENSMUSP00000030285; ENSMUSG00000028558 |
GeneIDi | 108802 |
KEGGi | mmu:108802 |
UCSCi | uc008uce.2, mouse |
Organism-specific databases
CTDi | 108802 |
MGIi | MGI:2140435, Calr4 |
Phylogenomic databases
eggNOGi | KOG0674, Eukaryota |
GeneTreei | ENSGT00950000182915 |
HOGENOMi | CLU_018224_0_2_1 |
OMAi | AQKPRKW |
OrthoDBi | 822188at2759 |
TreeFami | TF338438 |
Miscellaneous databases
BioGRID-ORCSi | 108802, 2 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028558, Expressed in primary oocyte and 54 other tissues |
ExpressionAtlasi | Q3TQS0, baseline and differential |
Family and domain databases
Gene3Di | 2.10.250.10, 2 hits |
InterProi | View protein in InterPro IPR001580, Calret/calnex IPR018124, Calret/calnex_CS IPR009169, Calreticulin IPR009033, Calreticulin/calnexin_P_dom_sf IPR013320, ConA-like_dom_sf |
PANTHERi | PTHR11073, PTHR11073, 1 hit |
Pfami | View protein in Pfam PF00262, Calreticulin, 2 hits |
PIRSFi | PIRSF002356, Calreticulin, 1 hit |
PRINTSi | PR00626, CALRETICULIN |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF63887, SSF63887, 1 hit |
PROSITEi | View protein in PROSITE PS00803, CALRETICULIN_1, 1 hit PS00804, CALRETICULIN_2, 1 hit PS00805, CALRETICULIN_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TQS0_MOUSE | |
Accessioni | Q3TQS0Primary (citable) accession number: Q3TQS0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |