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Protein

Telomere length and silencing protein 1 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of telomeric heterochromatin assembly and control of telomere length.By similarity

GO - Biological processi

  • regulation of mRNA splicing, via spliceosome Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere length and silencing protein 1 homologBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385132 BC005624

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275241 – 289Telomere length and silencing protein 1 homologAdd BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei147PhosphotyrosineCombined sources1
Modified residuei253PhosphothreonineBy similarity1
Modified residuei261PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3TQI7
PaxDbiQ3TQI7
PeptideAtlasiQ3TQI7
PRIDEiQ3TQI7

PTM databases

iPTMnetiQ3TQI7
PhosphoSitePlusiQ3TQI7

Expressioni

Gene expression databases

BgeeiENSMUSG00000026851 Expressed in 282 organ(s), highest expression level in brain
CleanExiMM_BC005624
GenevisibleiQ3TQI7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028205

Structurei

3D structure databases

ProteinModelPortaliQ3TQI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TLS1 family.

Phylogenomic databases

eggNOGiKOG3345 Eukaryota
ENOG410XTBJ LUCA
GeneTreeiENSGT00390000009787
HOGENOMiHOG000240083
HOVERGENiHBG055019
InParanoidiQ3TQI7
OMAiPFNVKTG
OrthoDBiEOG091G0QEQ
TreeFamiTF105871

Family and domain databases

InterProiView protein in InterPro
IPR010756 Tls1
PANTHERiPTHR13486 PTHR13486, 1 hit
PfamiView protein in Pfam
PF07052 Hep_59, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TQI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRITGKTFRR RRADSESEED EQESEEVRLK LEETREVQNL RKRPNGVSAA
60 70 80 90 100
ALLVGEKVQE ETTLVDDPFQ MATGGMVDMK KLKERGKDKV SEEEDLHLGT
110 120 130 140 150
SFSAETNRRD EDADMMKYIE TELKKRKGIV EQEEQKAKPK NAEDCLYELP
160 170 180 190 200
ENIRVSSAKK TEEMLSNQML SGIPEVDLGI DAKIKNIIST EDAKARLLAE
210 220 230 240 250
QQNKKKDSET SFVPTNMAVN YVQHNRFYHE ELNAPIRRNK EEPKARPLRV
260 270 280
GDTEKPEPER SPPNRKRPAN EKATDDYHYE KFKKMNRRY
Length:289
Mass (Da):33,544
Last modified:October 3, 2012 - v2
Checksum:iF4BF168DBE26EBFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35R → G in BAE37395 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163554 mRNA Translation: BAE37395.1
AK158706 mRNA Translation: BAE34621.1
AK168109 mRNA Translation: BAE40080.1
AL844532, AL844546 Genomic DNA Translation: CAM17868.1
AL844546, AL844532 Genomic DNA Translation: CAM18429.1
CH466542 Genomic DNA Translation: EDL08499.1
BC005624 mRNA Translation: AAH05624.1
CCDSiCCDS15892.1
RefSeqiNP_659134.1, NM_144885.2
UniGeneiMm.235238

Genome annotation databases

EnsembliENSMUST00000028205; ENSMUSP00000028205; ENSMUSG00000026851
GeneIDi227707
KEGGimmu:227707
UCSCiuc008jdd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163554 mRNA Translation: BAE37395.1
AK158706 mRNA Translation: BAE34621.1
AK168109 mRNA Translation: BAE40080.1
AL844532, AL844546 Genomic DNA Translation: CAM17868.1
AL844546, AL844532 Genomic DNA Translation: CAM18429.1
CH466542 Genomic DNA Translation: EDL08499.1
BC005624 mRNA Translation: AAH05624.1
CCDSiCCDS15892.1
RefSeqiNP_659134.1, NM_144885.2
UniGeneiMm.235238

3D structure databases

ProteinModelPortaliQ3TQI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028205

PTM databases

iPTMnetiQ3TQI7
PhosphoSitePlusiQ3TQI7

Proteomic databases

EPDiQ3TQI7
PaxDbiQ3TQI7
PeptideAtlasiQ3TQI7
PRIDEiQ3TQI7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028205; ENSMUSP00000028205; ENSMUSG00000026851
GeneIDi227707
KEGGimmu:227707
UCSCiuc008jdd.2 mouse

Organism-specific databases

MGIiMGI:2385132 BC005624

Phylogenomic databases

eggNOGiKOG3345 Eukaryota
ENOG410XTBJ LUCA
GeneTreeiENSGT00390000009787
HOGENOMiHOG000240083
HOVERGENiHBG055019
InParanoidiQ3TQI7
OMAiPFNVKTG
OrthoDBiEOG091G0QEQ
TreeFamiTF105871

Miscellaneous databases

PROiPR:Q3TQI7

Gene expression databases

BgeeiENSMUSG00000026851 Expressed in 282 organ(s), highest expression level in brain
CleanExiMM_BC005624
GenevisibleiQ3TQI7 MM

Family and domain databases

InterProiView protein in InterPro
IPR010756 Tls1
PANTHERiPTHR13486 PTHR13486, 1 hit
PfamiView protein in Pfam
PF07052 Hep_59, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLS1_MOUSE
AccessioniPrimary (citable) accession number: Q3TQI7
Secondary accession number(s): Q99JW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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